3,911 research outputs found
Bagging ensemble selection for regression
Bagging ensemble selection (BES) is a relatively new ensemble learning strategy. The strategy can be seen as an ensemble of the ensemble selection from libraries of models (ES) strategy. Previous experimental results on binary classiļ¬cation problems have shown that using random trees as base classiļ¬ers, BES-OOB (the most successful variant of BES) is competitive with (and in many cases, superior to) other ensemble learning strategies, for instance, the original ES algorithm, stacking with linear regression, random forests or boosting. Motivated by the promising results in classiļ¬cation, this paper examines the predictive performance of the BES-OOB strategy for regression problems. Our results show that the BES-OOB strategy outperforms Stochastic Gradient Boosting and Bagging when using regression trees as the base learners. Our results also suggest that the advantage of using a diverse model library becomes clear when the model library size is relatively large. We also present encouraging results indicating that the non negative least squares algorithm is a viable approach for pruning an ensemble of ensembles
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FAM222A encodes a protein which accumulates in plaques in Alzheimer's disease.
Alzheimer's disease (AD) is characterized by amyloid plaques and progressive cerebral atrophy. Here, we report FAM222A as a putative brain atrophy susceptibility gene. Our cross-phenotype association analysis of imaging genetics indicates a potential link between FAM222A and AD-related regional brain atrophy. The protein encoded by FAM222A is predominantly expressed in the CNS and is increased in brains of patients with AD and in an AD mouse model. It accumulates within amyloid deposits, physically interacts with amyloid-Ī² (AĪ²) via its N-terminal AĪ² binding domain, and facilitates AĪ² aggregation. Intracerebroventricular infusion or forced expression of this protein exacerbates neuroinflammation and cognitive dysfunction in an AD mouse model whereas ablation of this protein suppresses the formation of amyloid deposits, neuroinflammation and cognitive deficits in the AD mouse model. Our data support the pathological relevance of protein encoded by FAM222A in AD
International conference on software engineering and knowledge engineering: Session chair
The Thirtieth International Conference on Software Engineering and Knowledge Engineering (SEKE 2018) will be held at the Hotel Pullman, San Francisco Bay, USA, from July 1 to July 3, 2018. SEKE2018 will also be dedicated in memory of Professor Lofti Zadeh, a great scholar, pioneer and leader in fuzzy sets theory and soft computing.
The conference aims at bringing together experts in software engineering and knowledge engineering to discuss on relevant results in either software engineering or knowledge engineering or both. Special emphasis will be put on the transference of methods between both domains. The theme this year is soft computing in software engineering & knowledge engineering. Submission of papers and demos are both welcome
Speech Dereverberation Based on Integrated Deep and Ensemble Learning Algorithm
Reverberation, which is generally caused by sound reflections from walls,
ceilings, and floors, can result in severe performance degradation of acoustic
applications. Due to a complicated combination of attenuation and time-delay
effects, the reverberation property is difficult to characterize, and it
remains a challenging task to effectively retrieve the anechoic speech signals
from reverberation ones. In the present study, we proposed a novel integrated
deep and ensemble learning algorithm (IDEA) for speech dereverberation. The
IDEA consists of offline and online phases. In the offline phase, we train
multiple dereverberation models, each aiming to precisely dereverb speech
signals in a particular acoustic environment; then a unified fusion function is
estimated that aims to integrate the information of multiple dereverberation
models. In the online phase, an input utterance is first processed by each of
the dereverberation models. The outputs of all models are integrated
accordingly to generate the final anechoic signal. We evaluated the IDEA on
designed acoustic environments, including both matched and mismatched
conditions of the training and testing data. Experimental results confirm that
the proposed IDEA outperforms single deep-neural-network-based dereverberation
model with the same model architecture and training data
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