Theology, science and the topos of the Logos: a stable, dynamic topology of Creation

This thesis argues that an integrated, dynamically stable theo-science may be explored by considering scientific and theological perspectives regarding stability itself, combining them in one overarching framework by embedding a scientific conception of stability within a broader theological conception thereof. Our very capacity to perceive ‘reality’ in a functionally consistent manner is dependent upon the physical cosmos presenting a particular, dynamic stability, allowing for the sustainable emergence of life in the first place. Stability is hierarchically qualified, with higher-order functional systems such as those pertaining to life being an emergent result of particular modes of interaction between lower-level degrees of stability, ultimately right down to fundamental particles or fields. Theologically, any stability inherent to ‘reality’ must furthermore be considered to derive from the fact that such reality is, at its profoundest, a manifestation of God’s revealing, Creative Activity through the Logos. The thesis considers, qualitatively, the scientific and theological ‘place’ and relevance of stability from a holistic perspective regarding our anthropological development. Scientifically this is viewed in layered, evolutionary terms. Theologically, the Incarnation is considered of central relevance to our anthropological journey, transfiguring the process of its development so as to draw human nature into its intended eschatological stability ‘at the right hand of the Father’. Since stability can be considered scientifically in topological terms, the framework is developed by means of a ‘theological topology’ centred, as the etymology suggests, on the idea of a sacramentally stable, pervasive topos indicative of God’s ‘motioning’, Creative Activity through the Logos. Such Activity becomes sense-objectified in the Incarnation, considered figuratively-speaking as a ‘phase transition’, the net effect of which is argued as a ‘drawing in’ (cf. John 12:32), reordering and enhancing all meaningful, creaturely contribution to the ‘content’ of Creation – content actively generated according to our iconic, creative capacity for conceiving (of) the Logos

Systems biology of breast cancer

Breast cancer, with an alarming incidence rate throughout the globe, has attracted significant investigations to identify disease specific biomarkers. Among these, oestrogen receptor (ER) occupies a central role where overexpression is a prognostic indication for breast cancer. The cross-talk between the responsible contenders of ER-associated genes potentially play an important role in the disease aetiology. Investigation of such cross talk is the focus of this thesis. The development of high throughput technologies such as expression microarrays has paved the way for investigating thousands of genes at a time. Microarrays with their high data volume, multivariate nature and non-linearity pose challenges for analysing using conventional statistical approaches. To combat these challenges, computational researchers have developed machine learning approaches such as Artificial Neural Networks (ANNs). This thesis evaluates ANNs based methodologies and their application to the analysis of microarray data generated for breast cancer cases of differing oestrogen receptor status. Furthermore they are used for network inferencing to identify interactions between ER-associated markers and for the subsequent identification of putative pathway elements. The present thesis shows that it is possible to identify some ER-associated breast cancer relevant markers using ANNs. These have been subsequently validated on clinical breast tumour samples highlighting the promise of this approach

Contemporary Natural Philosophy and Philosophies - Part 1

This book is a printed edition of the Special Issue titled "Contemporary Natural Philosophy and Philosophies" - Part 1 that was published in the journal Philosophies

Reports to the President

A compilation of annual reports for the 1986-1987 academic year, including a report from the President of the Massachusetts Institute of Technology, as well as reports from the academic and administrative units of the Institute. The reports outline the year's goals, accomplishments, honors and awards, and future plans

Gabriel Vacariu (c2023 to 2014) The UNBELIEVABLE similarities between the ideas of some people (2006-2016) and my ideas (2002-2008) in physics (quantum mechanics, cosmology), cognitive neuroscience, philosophy of mind, and philosophy

Unbelievable similar ideas to my ideas published long before..