Primary multifocal osseous Hodgkin's lymphoma

BackgroundHodgkin's disease (HD) most commonly presents with progressive painless enlargement of peripheral lymph nodes, especially around the cervical region. A few children have systemic symptoms and weight loss. At the time of diagnosis, osseous involvement is uncommonCase presentationA case is described of Primary Multifocal Osseous Hodgkin's Lymphoma in a seven-year-old boy. He presented with a painful swelling in the sternum, and further investigations revealed deposits in his L1 vertebra, the left sacro-iliac joint and the right acetabulum.ConclusionThe clinical, radiological and histological features of this disease can mimic other medical conditions, including Tuberculosis, making the diagnosis difficult and often leading to delays in treatment. This is a very rare condition and we believe this to be the youngest reported case in the literature

Diagnostic accuracy of multidetector computed tomography scan in mediastinal masses assuming histopathological findings as gold standard

Purpose: Aim of the study was to: 1) present MDCT characteristics of different mediastinal mass lesions, 2) estimate proportion of benign and malignant mediastinal mass lesions based on MDCT findings, and 3) find out the diagnostic accuracy with sensitivity, specificity, positive predictive value, and negative predictive value of MDCT in mediastinal mass lesions assuming histopathology as gold standard. Material and methods: This study was an analysis of 60 patients who underwent MDCT scan for characterisation of mediastinal mass lesion, and subsequently imaging findings were verified with pathological diagnosis. Results: Out of 60 patients 65% were malignant and 35% were benign. Metastatic carcinoma was the leading diagnosis. Sensitivity of MDCT in this study came out to be 94%, specificity is 90%, with a positive predictive value of 94% and negative predictive value of 90% with diagnostic accuracy of 93%. Conclusions: Mediastinal mass lesion can be accurately diagnosed with MDCT which is a non-invasive and easily available modality requiring clinical data for accurate diagnosis and management. Co-relation of MDCT findings with other imaging findings is complex and requires adequate clinical data for optimum diagnostic confidence

Molecular characterization of canine peripheral T-cell lymphoma

Includes bibliographical references.2020 Summer.To view the abstract, please see the full text of the document

Guide for ferrets lymphoma

Ferrets popularity as pets is increasing in North America and Europe and appear more frequently in veterinary practice. Therefore, it is important to study this specie in order to provide advanced medical care. After insulinoma and adrenocortical neoplasia, lymphoma is the third more common neoplasia in domestic ferrets, and this condition appears to be increasing in frequency. Lymphoma can be described as a proliferation of neoplastic lymphoid cells, and can occur in ferrets of all ages and in practically all organ systems. Despite various theories, the exact etiology of lymphoma remains unknown. Although the increased incidence of lymphoma, there are still difficulties in obtaining an accurate diagnose of this neoplasia, lack of uniformity in its classification, and protocols to ensure an appropriate treatment. This article aims to present guide that gathers the information published about lymphoma in ferrets, and to provide an orientation on the diagnosis and treatment of ferrets with this neoplasia.Os furões são cada vez mais populares como animais de companhia na América do Norte e Europa, surgindo mais frequentemente na prática veterinária. Portanto, é cada vez mais importante conhecer esta espécie e estar apto a prestar cuidados médicos avançados. Depois do insulinoma e da neoplasia adrenocortical, o linfoma é a terceira neoplasia mais comum nos furões domésticos, estando a sua frequência a aumentar. O linfoma pode ser descrito como uma proliferação de células linfóides neoplásicas, e pode ocorrer em todas as faixas etárias e em praticamente todos os sistemas de órgãos. Apesar das várias teorias, a verdadeira etiologia do linfoma permanece desconhecida. Apesar da elevada incidência do linfoma, há ainda dificuldades em obter um diagnóstico preciso desta neoplasia, falta de uniformidade na sua classificação, e de protocolos que assegurem um tratamento apropriado. Este artigo tem como objectivo apresentar um guia que reúna a informação publicada acerca de linfoma em furões, e fornecer uma orientação no diagnóstico e tratamento de furões com esta neoplasia

On the Pathology of Hodgkin's Disease

In Part I an attempt was made to offer a brief and reasonably critical account of the inherent peculiarities of the structure and of the diseases of the reticulo---endothelial system. Particular emphasis was accorded to works which have served to integrate the concept of lymphoid tissue sarcoma. While it is doubtful whether knowledge is yet adequate enough to endorse this idea universally, it has the advantage of being a practical generalisation which simplifies the subject. The view that the morbid process, primary reticulosis, was covered by the generic lymphoid tissue sarcoma was also supported. In Part II some account was given of the lymphatics and lymphoid tissue. In this outline attention was drawn to the mysterious and bewildering problems inseparable from the system. The structure of lymph nodes was given with observations on their development, involution, and possible neogenesis in adult life. From these studies it emerged that the full complement of lymph nodes in the locus examined was probably attained in adolescence or early adult life, and that fat replacement was the usual mode of atrophy. Attention was also drawn to the rarity of fibrosis in physiological nodes, except where it was the result of blood vascular hyaline change. In Part III Hodgkin's disease was studied. In the introduction of this part of the work the historical aspect of the malady was recorded, with, it is hoped, advertisement of interesting and possibly less well-known facts about it. This was followed by a critical consideration on the nature of the disease and its morbid anatomy, the latter being /illustrated illustrated in part by analyses of the cases coming to necropsy at Glasgow Royal Infirmary over a period of fifty years. In this part also were the findings of a large series of biopsy specimens. Here endeavours were made to shew the microscopical variations in morphology in the lesion, and to demonstrate the affinities of other lymphoid tissue sarcomata with the disease. Within the resources available the generic lymphoid tissue sarcoma was established, and links between the better recognised variants were presented with a reasonable degree of conviction. In the necropsy series a detailed study of thirteen cases of Hodgkin's disease or reticulum cell sarcoma was offered. In these it was shewn that the favourite locus was lymphoid tissue, that complete systematisation was rare, and that metamorphosis to a more tumour-like lesion was common. In Part IV two components of the Hodgkin's disease complex were studied in relation to general pathology. The view that fibrosis, an essential and inherent peculiarity of the Hodgkin's disease lesion, was represented in certain other morbid states was submitted. This was illustrated by brief accounts of some diseases where quasi-neoplastic features are shewn by connective tissue. Eosinophilia in tumours was also made the subject of investigation and revealed that the phenomenon, while possibly not so rare as might be expected, was not nearly so common as in Hodgkin's disease. Some evidence was found for the cyto-metaplastic origin of eosinophiles in Hodgkin's disease, but possibly due to the restriction to histological as opposed to cytological methods, the results were not highly conclusive. In Part V an experimental attempt to reproduce the disease by /chronic chronic trypan blue poisoning of rats and mice proved unsuccessful, although interesting results followed. The main contention in this thesis has been that Hodgkin's disease is a neoplasm. Perhaps the following may influence the reader more convincingly than I have been able to do by so much work. The reasons for human beliefs depend chiefly upon Authority, Intuition, and Scientific Method. The last two have been exploited as far as I have been able; the foremost remains. As a junior student I saw a case of Hodgkin's disease first in the wards of the Late Professor Archibald Harrington, at Glasgow Royal Infirmary. I was chagrined at the doubt cast on its nature in the discussion which followed the demonstration; at twenty, one is very intolerant of obscure aetiology! On my return home I imprudently assailed my Father with the question at the dinner table, where even renal oedema was taboo. He was exceedingly angry. There was a dreadful silence, and then he relented - 'of course it is tumour, - but mind to whom you say that' Nothing more was said. I submit that this terse pronouncement has been my most precious axiom, with deepest respect and affection