Community in Tension (CiT)

The development and availability of Information Communication Technology (ICT) impacts many sectors yet a digital divide is still present amongst citizens in communities. Not only is there a digital divide evident but also many other factors that causes tension in communities. This paper defines a Community in Tension (CiT) as a community where the wellbeing of its citizens is being threatened. This provides an opportunity to use these available ICTs in communities and have it locally appropriated to empower the citizens and stabilise these communities

What's on your mind? Recent advances in memory detection using the concealed information test

Lie detectors can be applied in a wide variety of settings. But this advantage comes with a considerable cost: False positives. The applicability of the Concealed Information Test (CIT) is More limited, yet when it can be applied, the risk of false accusations can be set a priori at a very low level. The CIT assesses the recognition of; critical information that is known only by the examiners and the culprit, for example, the face a an accomplice. Large effects are Obtained with the CIT, whether combined with peripheral, brain, or Motor responses. We see three important challenges for the CIT. First, the false negative rate Of the CIT can be substantial, particularly under :realistic circumstantes. A possible solution Seems to restrict the CIT to highly Salient details. Second, there exist effective faking strategies. Future research will tell whether faking can be detected or even prevented (e.g., Using Overt measures). Third, recognition of critical crime detail's does not necessarily result from criminal activity. It is therefore important to properly embed the CIT in the investigative process, While taking care when drawing conclusions from the test outcome (recognition, not guilt)

Crisis Intervention Teams Assist Law Enforcement

A shorter version of this article appeared on pp. 5–7 of the Fall 2017 print edition.The Crisis Intervention Team (CIT) is a police-based, first responders’ pre-arrest jail diversion model for individuals with mental illness and/or substance abuse disorder. A new CIT coalition is being developed in Matanuska-Susitna Borough. The online version of the article also includes additional information about specialized police responses.Specialized training / Mat-Su adapts CIT / CIT requires culture shift / SIDEBAR: Specialized police response models / Reference

Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology

Combination immunotherapy (CIT) is currently applied as a treatment for different cancers and is proposed as a cure strategy for chronic viral infections. Whether such therapies are efficient during an acute infection remains elusive. To address this, inhibitory receptors were blocked and regulatory T cells depleted in acutely Friend retrovirus-infected mice. CIT resulted in a dramatic expansion of cytotoxic CD4+ and CD8+ T cells and a subsequent reduction in viral loads. Despite limited viral replication, mice developed fatal immunopathology after CIT. The pathology was most severe in the gastrointestinal tract and was mediated by granzyme B producing CD4+ and CD8+ T cells. A similar post-CIT pathology during acute Influenza virus infection of mice was observed, which could be prevented by vaccination. Melanoma patients who developed immune-related adverse events under immune checkpoint CIT also presented with expanded granzyme-expressing CD4+ and CD8+ T cell populations. Our data suggest that acute infections may induce immunopathology in patients treated with CIT, and that effective measures for infection prevention should be applied

Moving forward with combinatorial interaction testing

Combinatorial interaction testing (CIT) is an efficient and effective method of detecting failures that are caused by the interactions of various system input parameters. In this paper, we discuss CIT, point out some of the difficulties of applying it in practice, and highlight some recent advances that have improved CIT’s applicability to modern systems. We also provide a roadmap for future research and directions; one that we hope will lead to new CIT research and to higher quality testing of industrial systems