12,786 research outputs found
The human immunodeficiency virus type 1 Vpr protein and its carboxy-terminally truncated form induce apoptosis in tumor cells
The human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces apoptosis after cell cycle arrest at the G2 phase in primate cells. We have reported previously that C81, a carboxy-terminally truncated form of Vpr, interferes with cell proliferation and results in apoptosis without G2 arrest. Here, we investigated whether this property of Vpr and C81 could be exploited for use as a potential anticancer agent. First, we demonstrated that C81 induced G1 arrest and apoptosis in all tumor cells tested. In contrast, Vpr resulted in G2 arrest and apoptosis in HeLa and 293 T cells. Vpr also suppressed the damaged-DNA-specific binding protein 1 (DDB1) in HepG2 cells, thereby inducing apoptosis without G2 arrest. G2 arrest was restored when DDB1 was overexpressed in cells that also expressed Vpr. Surprisingly, C81 induced G2 arrest when DDB1 was overexpressed in HepG2 cells, but not in HeLa or 293 T cells. Thus, the induction of Vpr- and C81-mediated cell cycle arrest appears to depend on the cell type, whereas apoptosis was observed in all tumor cells tested. Overall, Vpr and C81 have potential as novel therapeutic agents for treatment of cancer
Optimal design application on the advanced aeroelastic rotor blade
The vibration and performance optimization procedure using regression analysis was successfully applied to an advanced aeroelastic blade design study. The major advantage of this regression technique is that multiple optimizations can be performed to evaluate the effects of various objective functions and constraint functions. The data bases obtained from the rotorcraft flight simulation program C81 and Myklestad mode shape program are analytically determined as a function of each design variable. This approach has been verified for various blade radial ballast weight locations and blade planforms. This method can also be utilized to ascertain the effect of a particular cost function which is composed of several objective functions with different weighting factors for various mission requirements without any additional effort
My2-Acetone-diacetone[my3-tris(trifluoromethyl)methanolato]bis[my2-tris(trifluoromethyl)methanolato]trilithium
The title compound, [Li3(C4F9O)3(C3H6O)3], features an open Li/O cube with an Li ion missing at one corner. Three of the four bridging O atoms of the cube carry a fluorinated tert-butyl residue, whereas the fourth is part of an acetone molecule. Two of the Li atoms are further bonded to a non-bridging acetone molecule. Two of the lithium ion coordination geometries are very distorted LiO4 tetrahedra; the third could be described as a very distorted LiO3 T-shape with two distant F-atom neighbours. The Li[cdots, three dots, centered]Li contact distances for the three-coordinate Li+ ion [2.608 (14) and 2.631 (12) Å] are much shorter that the contact distance [2.940 (13) Å] between the tetrahedrally coordinated species
GANIL RF systems : feedback control system and electronics
http://accelconf.web.cern.ch/AccelConf/c81/papers/ep-10.pdfInternational audienc
New aspects of nuclear physics with heavy ion beams delivered by cyclotrons
http://accelconf.web.cern.ch/AccelConf/c81/papers/gi-01.pdfInternational audienc
The GANIL control system as seen from the control room
http://accelconf.web.cern.ch/AccelConf/c81/papers/fp-08.pdfInternational audienc
Progress report and first operation of the GANIL injector
http://accelconf.web.cern.ch/AccelConf/c81/papers/abp-07.pdfInternational audienc
Tetraacetonitrilelithium tetraisothiocyanatoborate
The crystal structure of the title salt, [Li(CH3CN)4][B(NCS)4], is composed of discrete cations and anions. Both the Li and B atoms show a tetrahedral coordination by four equal ligands. The acetonitrile and isothiocyanate ligands are linear. The bond angles at the B atom are close to the ideal tetrahedral value [108.92 (18)–109.94 (16)°], but the bond angles at the Li atom show larger deviations [106.15 (17)–113.70 (17)°]
Two-loop matching of the dipole operators for and
The order corrections to the Wilson coefficients of the dipole
operators () at the matching scale are a crucial ingredient
for a complete next- to-leading logarithmic calculation of the branching ratio
for . Given the phenomenological relevance and the fact that
this two-loop calculation has been done so far only by one group [1], we
present a detailed re-calculation using a different method. Our results are in
complete agreement with those in ref. [1].Comment: 24 pages, latex, 6 figures include
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