Brain tumour growth in rats exposed to electromagnetic fields used in wireless cellular communication

In 1996 there was no convincing laboratory evidence that EMFs used in wireless communication could cause tumour promotion at non-thermal exposure levels. Therefore we then performed a study of the effects from exposure to such electromagnetic fields in the rat brain glioma model we were using in our research for brain tumour therapy. By stereotaxic technique rat glioma cells (RG2 or N32) were injected into the head of the right caudate nucleus in 154 pairs of Fischer 344 rats in both exposed and matched controls. Starting on day 5 after inoculation, the animals were exposed for 7 hours a day, 5 days a week during 2 - 3 weeks. Rats of both sexes were exposed to electromagnetic fields in the microwaves frequency range 915 MHz both as continuous waves (1 W), and as pulse-modulated at 4, 8, 16 and 217 Hz in 0.57 ms long pulses and 50 Hz in 6.67 ms pulses, all with a maximum power amplitude of 2 W per pulse. The animals were kept un-anaesthetized in well-ventilated TEM cells during 7 hours a day for 5 days a week for 2-3 weeks. Their matched controls were kept in identical TEM cells without EMF exposure. At the end of the exposure period the rat brains were examined histopathologically. The tumour size was measured with a calliper and the volume estimated as an ellipsoid. Our study of the 154 matched pairs of rats did not show any significant difference in tumour volume between animals exposed to 915 MHz microwaves, and those not exposed. Thus our results did not support that daily exposure to EMF promotes tumour growth when given from the fifth day after the start of tumour growth in the rat brain until the sacrifice of the animal 16 days later. In the present review our results published 1997 have been re-evaluated in terms of SAR dependence of tumour volume observed ratio (exposed / control). We thus surprisingly found that the shape of tumour volume-OR versus SAR response was of bath-tube pattern, similar to that found in our parallel studies of albumin leakage through the blood-brain barrier. Since the SAR varies between most other animal studies reviewed and human epidemiological studies this SAR dependence might explain the controversy in rendering the results

Emerging aspects of mobile phone use

The mobile phone is a modern-day invention, which has managed to reach many parts of the world enabling telecommunications across areas where it was not possible before. Although these devices have proved to be life saving in certain circumstances (e.g., after accidents) and helped improve the quality of life in some sectors, concerns continue to be raised about potential adverse health impacts associated with their use. These range from cancer and cognitive deficiencies to subjective effects, such as a feeling of warmth around the ear used, headache and fatigue. We provide an overview of the concerns raised and summarise what is known about them. We conducted a literature search in Pubmed/Medline to identify published papers on health effects of mobile phones, and an intensive search on the Internet to collect data on the global use of mobile phones. In the year 2000, there were an estimated 500 million mobile phone users worldwide. Today, there are about 3.3 billion users. The use of mobile phones among young children and adolescents is also increasing. Health-risk research has mainly focused on adults and on a single outcome, brain tumours. No significant relationship has been established between mobile phone use and the incidence or growth of brain tumours. Other research indicates emerging concerns, including hearing problems and self-reported health symptoms, such as tiredness, stress, headache, anxiety, concentration difficulties and sleep disturbances, but results remain inconclusive. Currently, there is little epidemiological evidence indicating that the use of mobile phones causes adverse health effects

Wireless Signals and Male Fertility

Rapid advances in wireless technology have increased the number of users of mobile devices. As of 2011, the number of cell phone subscribers have reached 5.3 billion worldwide. Mobile devices have saturated our environment with radio frequency (RF) signals. This situation has created public concern over the effect of such signals on human health. This dissertation focuses on the correlation of RF signals emitted by cell phones with male infertility. A thorough discussion is provided on the effects of RF signals on the development of central nervous system (CNS) neoplasm, the design of these mobile devices, the range of the RF frequencies they emit, the power with which they operate, their specific absorption rate (SAR), the distance between the user and the device while in use, how and where the devices are used, the duration of usage, and the accumulated exposure associated with the use of multiple RF devices. The results of our reviews and experimental in vitro studies show a significant correlation between the usage of mobile phones and human semen parameters, with a decrease in motility and viability, and an increase in the reactive oxygen species (ROS) score. However, in daily usage, a cell phone kept in proximity to the groin is separated from the testes by multiple layers of tissue. To explore this effect, a computational model of scrotal tissues was designed. Our results show that during in vitro experimentation, an effect equivalent to real-life conditions can be obtained by placing the cell phone a few centimeters farther away from the semen sample. The results of our study can be used to calculate the equivalent distance between a radiation source and a semen sample, and to set up in vitro experiments that mimic real-life condition

Wireless Signals and Male Fertility

Rapid advances in wireless technology have increased the number of users of mobile devices. As of 2011, the number of cell phone subscribers have reached 5.3 billion worldwide. Mobile devices have saturated our environment with radio frequency (RF) signals. This situation has created public concern over the effect of such signals on human health. This dissertation focuses on the correlation of RF signals emitted by cell phones with male infertility. A thorough discussion is provided on the effects of RF signals on the development of central nervous system (CNS) neoplasm, the design of these mobile devices, the range of the RF frequencies they emit, the power with which they operate, their specific absorption rate (SAR), the distance between the user and the device while in use, how and where the devices are used, the duration of usage, and the accumulated exposure associated with the use of multiple RF devices. The results of our reviews and experimental in vitro studies show a significant correlation between the usage of mobile phones and human semen parameters, with a decrease in motility and viability, and an increase in the reactive oxygen species (ROS) score. However, in daily usage, a cell phone kept in proximity to the groin is separated from the testes by multiple layers of tissue. To explore this effect, a computational model of scrotal tissues was designed. Our results show that during in vitro experimentation, an effect equivalent to real-life conditions can be obtained by placing the cell phone a few centimeters farther away from the semen sample. The results of our study can be used to calculate the equivalent distance between a radiation source and a semen sample, and to set up in vitro experiments that mimic real-life condition

Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones.

The possible risks of radio-frequency electromagnetic fields for the human body is a growing concern for our society. We have previously shown that weak pulsed microwaves give rise to a significant leakage of albumin through the blood-brain barrier. In this study we investigated whether a pathologic leakage across the blood-brain barrier might be combined with damage to the neurons. Three groups each of eight rats were exposed for 2 hr to Global System for Mobile Communications (GSM) mobile phone electromagnetic fields of different strengths. We found highly significant (p< 0.002) evidence for neuronal damage in the cortex, hippocampus, and basal ganglia in the brains of exposed rats

Effects of Electromagnetic Waves Emitted by Mobile Phones on Male Fertility

With the increase use of cell phones, there are possible interactions of electromagnetic radiation hazard on human beings and their offspring. The recent upsurges of global interest of cell phone have created a fresh impetus on the development of natural disaster, which may or may not lead to cancer or birth defects. The objective of the biological evaluation is to find out the potential of cell phone on sperm cells having some new unknown effects. While thermal effects at the present level of cell phone radiation are negligible, most of the biological interactions are attributed to non-thermal effects. Male reproductive system is highly compartmentalized and sensitive biological system that requires the integration of intrinsic and extrinsic factors to properly function. The generated electrical currents may alter the hormonal milieu and testicular microenvironment, necessary for sperm production. Additionally, sperm are electrically active cells and their exposure to cell phone electromagnetic waves and currents may affect their motility, morphology and even their count. Leaky plasma membranes, calcium depletion and oxidative stress are the postulated cellular mechanisms mediating the harmful effects of cell phones radiation on sperm and male fertility potentials. Evidences for such impacts come from designed animal and in vitro studies which may be different from in vivo human exposure. Nevertheless, the important advice is to apply strict regulations on further increase in the power density of the emitted cell phone radiation and to conduct in vivo human research to study its negative effects on fertility.   Key words:   Cell phone, electromagnetic waves, male infertility, sperm

Exposure to radio-frequency electromagnetic waves alters acetylcholinesterase gene expression, exploratory and motor coordinationlinked behaviour in male rats

Humans in modern society are exposed to an ever-increasing number of electromagnetic fields (EMFs) and some studies have demonstrated that these waves can alter brain function but the mechanism still remains unclear. Hence, this study sought to investigate the effect of 2.5 Ghz band radio-frequency electromagnetic waves (RFEMF) exposure on cerebral cortex acetylcholinesterase (AChE) activity and their mRNA expression level as well as locomotor function and anxiety-linked behaviour in male rats. Animals were divided into four groups namely; group 1 was control (without exposure), group 2–4 were exposed to 2.5 Ghz radiofrequency waves from an installed WI-FI device for a period of 4, 6 and 8 weeks respectively. The results revealed that WiFi exposure caused a significant increase in anxiety level and affect locomotor function. Furthermore, there was a significant decrease in AChE activity with a concomitant increase in AChE mRNA expression level in WiFi exposed rats when compared with control. In conclusions, these data showed that long term exposure to WiFi may lead to adverse effects such as neurodegenerative diseases as observed by a significant alteration on AChE gene expression and some neurobehavioral parameters associated with brain damage

EFFECT OF MAGNETIC FIELD FROM MOBILE PHONE ON CENTRAL NERVOUS SYSTEM

Devices such as mobile phones, wireless internet modems, and radios and televisions, which occupy an important place in social life, produce electromagnetic fields (EMFs). Widespread use of these devices in daily life increases the intensity of exposure to EMFs on a day to day basis. Investigation of the effects on health of devices such as mobile phones used in close proximity to the body is attracting considerable interest from scientists. Mobile phones manufactured using the latest technology operate in a high frequency range (3003000 MHz). This further heightens concerns regarding the effect of mobile phones on human health. Most Global System for Mobile Communications (GSM) operators in Europe, Asia, and Africa use a frequency of 900 MHz. With the rapid development of electronic information and communication techniques, exposure to electromagnetic fields (EMFs) has increased dramatically. Some studies have focused on the biological effects of electromagnetic radiation. Microwave radiation has been reported as producing adverse effects in the central nervous system (CNS), including headache, sleep disorders, anxiety, cognitive dysfunction and neurogenesis impairment in both humans and animals. However, the direct effects of microwave radiation on neurodevelopment and the underlying mechanisms for any such effects remain unknown. As per todays global scenario use of mobile phone is increasing day by day for communication. Due to its constant use, the electromagnetic radiation (EMR) emitted from the cell phone, base station and other household appliances cause adverse effects on human health. There is an increase concern about the interaction of EMR generated from mobile phones, with the human organs specially with brain because of its close and long proximity to human brain during the mobile usage. Concerns have shown whether these exposures could have effect on brain and central nervous system (CNS)

The Largest Unethical Medical Experiment in Human History

This monograph describes the largest unethical medical experiment in human history: the implementation and operation of non-ionizing non-visible EMF radiation (hereafter called wireless radiation) infrastructure for communications, surveillance, weaponry, and other applications. It is unethical because it violates the key ethical medical experiment requirement for “informed consent” by the overwhelming majority of the participants. The monograph provides background on unethical medical research/experimentation, and frames the implementation of wireless radiation within that context. The monograph then identifies a wide spectrum of adverse effects of wireless radiation as reported in the premier biomedical literature for over seven decades. Even though many of these reported adverse effects are extremely severe, the true extent of their severity has been grossly underestimated. Most of the reported laboratory experiments that produced these effects are not reflective of the real-life environment in which wireless radiation operates. Many experiments do not include pulsing and modulation of the carrier signal, and most do not account for synergistic effects of other toxic stimuli acting in concert with the wireless radiation. These two additions greatly exacerbate the severity of the adverse effects from wireless radiation, and their neglect in current (and past) experimentation results in substantial under-estimation of the breadth and severity of adverse effects to be expected in a real-life situation. This lack of credible safety testing, combined with depriving the public of the opportunity to provide informed consent, contextualizes the wireless radiation infrastructure operation as an unethical medical experiment