Optimizing text mining methods for improving biomedical natural language processing

The overwhelming amount and the increasing rate of publication in the biomedical domain make it difficult for life sciences researchers to acquire and maintain all information that is necessary for their research. Pubmed (the primary citation database for the biomedical literature) currently contains over 21 million article abstracts and more than one million of them were published in 2020 alone. Even though existing article databases provide capable keyword search services, typical everyday-life queries usually return thousands of relevant articles. For instance, a cancer research scientist may need to acquire a complete list of genes that interact with BRCA1 (breast cancer 1) gene. The PubMed keyword search for BRCA1 returns over 16,500 article abstracts, making manual inspection of the retrieved documents impractical. Missing even one of the interacting gene partners in this scenario may jeopardize successful development of a potential new drug or vaccine. Although manually curated databases of biomolecular interactions exist, they are usually not up-to-date and they require notable human effort to maintain. To summarize, new discoveries are constantly being shared within the community via scientific publishing, but unfortunately the probability of missing vital information for research in life sciences is increasing. In response to this problem, the biomedical natural language processing (BioNLP) community of researchers has emerged and strives to assist life sciences researchers by building modern language processing and text mining tools that can be applied at large-scale and scan the whole publicly available literature and extract, classify, and aggregate the information found within, thus keeping life sciences researchers always up-to-date with the recent relevant discoveries and facilitating their research in numerous fields such as molecular biology, biomedical engineering, bioinformatics, genetics engineering and biochemistry. My research has almost exclusively focused on biomedical relation and event extraction tasks. These foundational information extraction tasks deal with automatic detection of biological processes, interactions and relations described in the biomedical literature. Precisely speaking, biomedical relation and event extraction systems can scan through a vast amount of biomedical texts and automatically detect and extract the semantic relations of biomedical named entities (e.g. genes, proteins, chemical compounds, and diseases). The structured outputs of such systems (i.e., the extracted relations or events) can be stored as relational databases or molecular interaction networks which can easily be queried, filtered, analyzed, visualized and integrated with other structured data sources. Extracting biomolecular interactions has always been the primary interest of BioNLP researcher because having knowledge about such interactions is crucially important in various research areas including precision medicine, drug discovery, drug repurposing, hypothesis generation, construction and curation of signaling pathways, and protein function and structure prediction. State-of-the-art relation and event extraction methods are based on supervised machine learning, requiring manually annotated data for training. Manual annotation for the biomedical domain requires domain expertise and it is time-consuming. Hence, having minimal training data for building information extraction systems is a common case in the biomedical domain. This demands development of methods that can make the most out of available training data and this thesis gathers all my research efforts and contributions in that direction. It is worth mentioning that biomedical natural language processing has undergone a revolution since I started my research in this field almost ten years ago. As a member of the BioNLP community, I have witnessed the emergence, improvement– and in some cases, the disappearance–of many methods, each pushing the performance of the best previous method one step further. I can broadly divide the last ten years into three periods. Once I started my research, feature-based methods that relied on heavy feature engineering were dominant and popular. Then, significant advancements in the hardware technology, as well as several breakthroughs in the algorithms and methods enabled machine learning practitioners to seriously utilize artificial neural networks for real-world applications. In this period, convolutional, recurrent, and attention-based neural network models became dominant and superior. Finally, the introduction of transformer-based language representation models such as BERT and GPT impacted the field and resulted in unprecedented performance improvements on many data sets. When reading this thesis, I demand the reader to take into account the course of history and judge the methods and results based on what could have been done in that particular period of the history

A study on developing novel methods for relation extraction

Relation Extraction (RE) is a task of Natural Language Processing (NLP) to detect and classify the relations between two entities. Relation extraction in the biomedical and scientific literature domain is challenging as text can contain multiple pairs of entities in the same instance. During the course of this research, we developed an RE framework (RelEx), which consists of five main RE paradigms: rule-based, machine learning-based, Convolutional Neural Network (CNN)-based, Bidirectional Encoder Representations from Transformers (BERT)-based, and Graph Convolutional Networks (GCNs)-based approaches. RelEx\u27s rule-based approach uses co-location information of the entities to determine whether a relation exists between a selected entity and the other entities. RelEx\u27s machine learning-based approach consists of traditional feature representations into traditional machine learning algorithms. RelEx\u27s CNN-based approach consists of three CNN architectures: Segment-CNN, single-label Sentence-CNN, and multi-label Sentence-CNN. RelEx\u27s BERT-based approach utilizes BERT\u27s contextualized word embeddings into a feed-forward neural network. Finally, RelEx\u27s GCN-based approach consists of two GCN-based architectures: GCN-Vanilla, GCN-BERT. We evaluated variations of these approaches in two different domains across four distinct relation types. Overall our findings showed that the rule-based approach is applicable for data with fewer instances in the training data. In contrast, the CNN-based, BERT-based, and GCN-based approaches perform better with labeled data with many training instances. These approaches automatically identify patterns in the data efficiently, whereas rule-based approaches require expert knowledge to generate rules. The CNN-based, BERT-based approaches capture the local contextual information within a sentence or document by embedding both semantic and syntactic information in a learned representation. However, their ability to capture the long-range dependency global information in a text is limited. GCN-based approaches capture the global association information by performing convolution operations on neighbor nodes in a graph and incorporating information from neighbors. Combining GCN with BERT integrates the local contextual and global association information of the words and generates better representations for the words

A recurrent neural network architecture for biomedical event trigger classification

A “biomedical event” is a broad term used to describe the roles and interactions between entities (such as proteins, genes and cells) in a biological system. The task of biomedical event extraction aims at identifying and extracting these events from unstructured texts. An important component in the early stage of the task is biomedical trigger classification which involves identifying and classifying words/phrases that indicate an event. In this thesis, we present our work on biomedical trigger classification developed using the multi-level event extraction dataset. We restrict the scope of our classification to 19 biomedical event types grouped under four broad categories - Anatomical, Molecular, General and Planned. While most of the existing approaches are based on traditional machine learning algorithms which require extensive feature engineering, our model relies on neural networks to implicitly learn important features directly from the text. We use natural language processing techniques to transform the text into vectorized inputs that can be used in a neural network architecture. As per our knowledge, this is the first time neural attention strategies are being explored in the area of biomedical trigger classification. Our best results were obtained from an ensemble of 50 models which produced a micro F-score of 79.82%, an improvement of 1.3% over the previous best score

A Survey on Arabic Named Entity Recognition: Past, Recent Advances, and Future Trends

As more and more Arabic texts emerged on the Internet, extracting important information from these Arabic texts is especially useful. As a fundamental technology, Named entity recognition (NER) serves as the core component in information extraction technology, while also playing a critical role in many other Natural Language Processing (NLP) systems, such as question answering and knowledge graph building. In this paper, we provide a comprehensive review of the development of Arabic NER, especially the recent advances in deep learning and pre-trained language model. Specifically, we first introduce the background of Arabic NER, including the characteristics of Arabic and existing resources for Arabic NER. Then, we systematically review the development of Arabic NER methods. Traditional Arabic NER systems focus on feature engineering and designing domain-specific rules. In recent years, deep learning methods achieve significant progress by representing texts via continuous vector representations. With the growth of pre-trained language model, Arabic NER yields better performance. Finally, we conclude the method gap between Arabic NER and NER methods from other languages, which helps outline future directions for Arabic NER.Comment: Accepted by IEEE TKD

Deep learning methods for knowledge base population

Knowledge bases store structured information about entities or concepts of the world and can be used in various applications, such as information retrieval or question answering. A major drawback of existing knowledge bases is their incompleteness. In this thesis, we explore deep learning methods for automatically populating them from text, addressing the following tasks: slot filling, uncertainty detection and type-aware relation extraction. Slot filling aims at extracting information about entities from a large text corpus. The Text Analysis Conference yearly provides new evaluation data in the context of an international shared task. We develop a modular system to address this challenge. It was one of the top-ranked systems in the shared task evaluations in 2015. For its slot filler classification module, we propose contextCNN, a convolutional neural network based on context splitting. It improves the performance of the slot filling system by 5.0% micro and 2.9% macro F1. To train our binary and multiclass classification models, we create a dataset using distant supervision and reduce the number of noisy labels with a self-training strategy. For model optimization and evaluation, we automatically extract a labeled benchmark for slot filler classification from the manual shared task assessments from 2012-2014. We show that results on this benchmark are correlated with slot filling pipeline results with a Pearson's correlation coefficient of 0.89 (0.82) on data from 2013 (2014). The combination of patterns, support vector machines and contextCNN achieves the best results on the benchmark with a micro (macro) F1 of 51% (53%) on test. Finally, we analyze the results of the slot filling pipeline and the impact of its components. For knowledge base population, it is essential to assess the factuality of the statements extracted from text. From the sentence "Obama was rumored to be born in Kenya", a system should not conclude that Kenya is the place of birth of Obama. Therefore, we address uncertainty detection in the second part of this thesis. We investigate attention-based models and make a first attempt to systematize the attention design space. Moreover, we propose novel attention variants: External attention, which incorporates an external knowledge source, k-max average attention, which only considers the vectors with the k maximum attention weights, and sequence-preserving attention, which allows to maintain order information. Our convolutional neural network with external k-max average attention sets the new state of the art on a Wikipedia benchmark dataset with an F1 score of 68%. To the best of our knowledge, we are the first to integrate an uncertainty detection component into a slot filling pipeline. It improves precision by 1.4% and micro F1 by 0.4%. In the last part of the thesis, we investigate type-aware relation extraction with neural networks. We compare different models for joint entity and relation classification: pipeline models, jointly trained models and globally normalized models based on structured prediction. First, we show that using entity class prediction scores instead of binary decisions helps relation classification. Second, joint training clearly outperforms pipeline models on a large-scale distantly supervised dataset with fine-grained entity classes. It improves the area under the precision-recall curve from 0.53 to 0.66. Third, we propose a model with a structured prediction output layer, which globally normalizes the score of a triple consisting of the classes of two entities and the relation between them. It improves relation extraction results by 4.4% F1 on a manually labeled benchmark dataset. Our analysis shows that the model learns correct correlations between entity and relation classes. Finally, we are the first to use neural networks for joint entity and relation classification in a slot filling pipeline. The jointly trained model achieves the best micro F1 score with a score of 22% while the neural structured prediction model performs best in terms of macro F1 with a score of 25%

On the Evolution of Knowledge Graphs: A Survey and Perspective

Knowledge graphs (KGs) are structured representations of diversified knowledge. They are widely used in various intelligent applications. In this article, we provide a comprehensive survey on the evolution of various types of knowledge graphs (i.e., static KGs, dynamic KGs, temporal KGs, and event KGs) and techniques for knowledge extraction and reasoning. Furthermore, we introduce the practical applications of different types of KGs, including a case study in financial analysis. Finally, we propose our perspective on the future directions of knowledge engineering, including the potential of combining the power of knowledge graphs and large language models (LLMs), and the evolution of knowledge extraction, reasoning, and representation