366 research outputs found
Aeronautical engineering: A continuing bibliography with indexes (supplement 267)
This bibliography lists 661 reports, articles, and other documents introduced into the NASA scientific and technical information system in June, 1991. Subject coverage includes design, construction and testing of aircraft and aircraft engines; aircraft components, equipment and systems; ground support systems; theoretical and applied aspects of aerodynamics and general fluid dynamics; electrical engineering; aircraft control; remote sensing; computer sciences; nuclear physics; and social sciences
Translation of Intravascular Optical Ultrasound Imaging
ances in the field of intravascular imaging have provided clinicians with power ful tools to aid in the assessment and treatment of vascular pathology. Optical Ultra sound (OpUS) is an emerging modality with the potential to offer significant bene fits over existing commercial technologies such as intravascular ultrasound (IVUS)
or optical coherence tomography (OCT). With this paradigm ultrasound (US) is
generated using pulsed or modulated light and received by a miniaturised fibre-optic
hydrophone (FOH). The US generation is facilitated through the use of engineered
optically-absorbing nanocomposite materials. To date pre-clinical benchtop stud ies of OpUS have shown significant promise however further study is needed to
facilitate clinical translation.
The overall aim of this PhD was to develop a pathway to clinical translation
of OpUS, enabled by the development of a catheter-based device capable of high
resolution vascular tissue imaging during an in-vivo setting.
A forward-viewing OpUS imaging probe was developed using a 400 µm mul timode optical fibre, dip-coated in a multi-walled carbon nanotube-PDMS com posite, paired with a FOH comprising a 125 µm single mode fibre tipped with a
Fabry-Perot cavity. With this high US pressures were generated (21.5 MPa at the
transducer surface) and broad corresponding bandwidths were achieved (−6 dB of
39.8MHz). Using this probe, OpUS imaging was performed of an ex-vivo human
coronary artery. The results demonstrated excellent correspondence, in the detec tion of calcification and lipid infiltration, with IVUS, OCT and histological analysis.
A side-viewing OpUS imaging probe, employing a reflective 45 °angle at the dis tal fibre surface, was used to demonstrate rotational B-mode imaging of a vascular structure for the first time. This provided high-resolution imaging (54 µm axial
resolution) with deep depth penetration (>10.5 mm). Finally the clinical utility of
this technology was demonstrated during an in-vivo endovascular procedure. An
OpUS imaging probe, incorporated into an interventional device, allowed guidance
of in-situ fenestration of an endograft during a complex abdominal aortic aneurysm
repair.
Through this work the potential clinical utility of OpUS, to assess pathology
and guide vascular intervention, has been demonstrated. These results pave the way
for translation of this technology and a first in man study
Development, modelling and control of a multi-degree-of-freedom dynamic wind tunnel rig
EThOS - Electronic Theses Online ServiceGBUnited Kingdo
Aeronautical engineering: A continuing bibliography with indexes (supplement 255)
This bibliography lists 529 reports, articles, and other documents introduced into the NASA scientific and technical information system in June 1990. Subject coverage includes: design, construction and testing of aircraft and aircraft engines; aircraft components, equipment and systems; ground support systems; and theoretical and applied aspects of aerodynamics and general fluid dynamics
Aeronautical engineering: A continuing bibliography with indexes (supplement 291)
This bibliography lists 757 reports, articles, and other documents introduced into the NASA scientific and technical information system in May. 1993. Subject coverage includes: design, construction and testing of aircraft and aircraft engines; aircraft components, equipment, and systems; ground support systems; and theoretical and applied aspects of aerodynamics and general fluid dynamics
Aeronautical engineering: A continuing bibliography with indexes (supplement 237)
This bibliography lists 572 reports, articles, and other documents introduced into the NASA scientific and technical information system in February, 1989. Subject coverage includes: design, construction and testing of aircraft and aircraft engines; aircraft components, equipment and systems; ground support systems; and theoretical and applied aspects of aerodynamics and general fluid dynamics
Aeronautical Engineering: A continuing bibliography with indexes (supplement 205)
This bibliography lists 517 reports, articles and other documents introduced into the NASA scientific and technical information system in September 1986
Aeronautical Engineering: A continuing bibliography with indexes (supplement 207)
This bibliography lists 484 reports, articles and other documents introduced into the NASA scientific and technical information system in November 1986
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