2,846 research outputs found

    Valorar la factibilidad para la expansión de las operaciones de la microempresa FINO en la provincia del Azuay

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    Para abordar este estudio, se llevaron a cabo diversas etapas de investigación y análisis. Se evaluó la demanda a través de un estudio de mercado el cual proporcionó una visión clara de las oportunidades y desafíos que enfrentaría FINO al expandirse. Además, se llevó a cabo un análisis del entorno empresarial, considerando factores económicos, políticos, sociales y ambientales que podrían afectar la operación de FINO en la provincia. En paralelo, se examinaron las operaciones internas de la empresa, evaluando su capacidad actual para gestionar una expansión. Con base en los hallazgos de estos análisis, se formularon propuestas de mejora concretas y viables para que FINO pueda abordar eficazmente la expansión en el Azuay y en el futuro en el resto del país. Finalmente se realizó un estudio financiero completo que incluyó proyecciones de ingresos y gastos relacionados con la expansión propuesta. Los resultados de este análisis financiero indicaron que la expansión de operaciones es económicamente viable y potencialmente rentable para la empresa. En resumen, esta tesis ha proporcionado una evaluación integral de la expansión de operaciones de FINO en la provincia del Azuay. A través del análisis de mercado, el entorno empresarial, las operaciones internas y el estudio financiero, se ha demostrado que la expansión es una decisión estratégica factible que puede contribuir al crecimiento y éxito continuo de la empresa en la provincia.To address this study, various stages of research and analysis were carried out. Demand was evaluated through a market study which provided a clear vision of the opportunities and challenges that FINO would face when expanding. In addition, an analysis of the business environment was carried out, considering economic, political, social and environmental factors that could affect FINO's operation in the province. In parallel, the company's internal operations were examined, evaluating its current capacity to manage expansion. Based on the findings of these analyses, concrete and viable improvement proposals were formulated so that FINO can effectively address expansion in Azuay. Finally, a complete financial study was conducted that included projections of income and expenses related to the proposed expansion. The results of this financial analysis indicated that the expansion of operations is economically viable and potentially profitable for the company. In summary, this thesis has provided a comprehensive evaluation of the expansion of FINO operations in the province of Azuay. Through market analysis, business environment, internal operations and financial study, expansion has been shown to be a feasible strategic decision that can contribute to the continued growth and success of the company in the province0000-0003-4123-264

    A diamond nanophotonic interface with an optically accessible deterministic electronuclear spin register

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    A contemporary challenge for the scalability of quantum networks is developing quantum nodes with simultaneous high photonic efficiency and long-lived qubits. Here, we present a fibre-packaged nanophotonic diamond waveguide hosting a tin-vacancy centre with a spin-1/2 117^{117}Sn nucleus. The interaction between the electronic and nuclear spins results in a signature 452(7) MHz hyperfine splitting. This exceeds the natural optical linewidth by a factor of 16, enabling direct optical nuclear-spin initialisation with 98.6(3)% fidelity and single-shot readout with 80(1)% fidelity. The waveguide-to-fibre extraction efficiency of our device of 57(6)% enables the practical detection of 5-photon events. Combining the photonic performance with the optically initialised nuclear spin, we demonstrate a spin-gated single-photon nonlinearity with 11(1)% contrast in the absence of an external magnetic field. These capabilities position our nanophotonic interface as a versatile quantum node in the pursuit of scalable quantum networks

    Speculative futures on ChatGPT and generative artificial intelligence (AI): a collective reflection from the educational landscape

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    While ChatGPT has recently become very popular, AI has a long history and philosophy. This paper intends to explore the promises and pitfalls of the Generative Pre-trained Transformer (GPT) AI and potentially future technologies by adopting a speculative methodology. Speculative future narratives with a specific focus on educational contexts are provided in an attempt to identify emerging themes and discuss their implications for education in the 21st century. Affordances of (using) AI in Education (AIEd)and possible adverse effects are identified and discussed which emerge from the narratives. It is argued that now is the best of times to define human vs AI contribution to education because AI can accomplish more and more educational activities that used to be the prerogative of human educators. Therefore, it is imperative to rethink the respective roles of technology and human educators in education with a future-oriented mindse

    The Development of Microdosimetric Instrumentation for Quality Assurance in Heavy Ion Therapy, Boron Neutron Capture Therapy and Fast Neutron Therapy

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    This thesis presents research for the development of new microdosimetric instrumentation for use with solid-state microdosimeters in order to improve their portability for radioprotection purposes and for QA in various hadron therapy modalities. Monte Carlo simulation applications are developed and benchmarked, pertaining to the context of the relevant therapies considered. The simulation and experimental findings provide optimisation recommendations relating to microdosimeter performance and possible radioprotection risks by activated materials. The first part of this thesis is continuing research into the development of novel Silicon-on-Insulator (SOI) microdosimeters in the application of hadron therapy QA. This relates specifically to the optimisation of current microdosimeters, development of Monte Carlo applications for experimental validation, assessment of radioprotection risks during experiments and advanced Monte Carlo modelling of various accelerator beamlines. Geant4 and MCNP6 Monte Carlo codes are used extensively in this thesis, with rigorous benchmarking completed in the context of experimental verification, and evaluation of the similarities and differences when simulating relevant hadron therapy facilities. The second part of this thesis focuses on the development of a novel wireless microdosimetry system - the Radiodosimeter, to improve the operation efficiency and minimise any radioprotection risks. The successful implementation of the wireless Radiodosimeter is considered as an important milestone in the development of a microdosimetry system that can be operated by an end-user with no prior knowledge

    Studies on genetic and epigenetic regulation of gene expression dynamics

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    The information required to build an organism is contained in its genome and the first biochemical process that activates the genetic information stored in DNA is transcription. Cell type specific gene expression shapes cellular functional diversity and dysregulation of transcription is a central tenet of human disease. Therefore, understanding transcriptional regulation is central to understanding biology in health and disease. Transcription is a dynamic process, occurring in discrete bursts of activity that can be characterized by two kinetic parameters; burst frequency describing how often genes burst and burst size describing how many transcripts are generated in each burst. Genes are under strict regulatory control by distinct sequences in the genome as well as epigenetic modifications. To properly study how genetic and epigenetic factors affect transcription, it needs to be treated as the dynamic cellular process it is. In this thesis, I present the development of methods that allow identification of newly induced gene expression over short timescales, as well as inference of kinetic parameters describing how frequently genes burst and how many transcripts each burst give rise to. The work is presented through four papers: In paper I, I describe the development of a novel method for profiling newly transcribed RNA molecules. We use this method to show that therapeutic compounds affecting different epigenetic enzymes elicit distinct, compound specific responses mediated by different sets of transcription factors already after one hour of treatment that can only be detected when measuring newly transcribed RNA. The goal of paper II is to determine how genetic variation shapes transcriptional bursting. To this end, we infer transcriptome-wide burst kinetics parameters from genetically distinct donors and find variation that selectively affects burst sizes and frequencies. Paper III describes a method for inferring transcriptional kinetics transcriptome-wide using single-cell RNA-sequencing. We use this method to describe how the regulation of transcriptional bursting is encoded in the genome. Our findings show that gene specific burst sizes are dependent on core promoter architecture and that enhancers affect burst frequencies. Furthermore, cell type specific differential gene expression is regulated by cell type specific burst frequencies. Lastly, Paper IV shows how transcription shapes cell types. We collect data on cellular morphologies, electrophysiological characteristics, and measure gene expression in the same neurons collected from the mouse motor cortex. Our findings show that cells belonging to the same, distinct transcriptomic families have distinct and non-overlapping morpho-electric characteristics. Within families, there is continuous and correlated variation in all modalities, challenging the notion of cell types as discrete entities

    The Perception of K-12 Instrumental Directors in Low-Income Areas on Virtual Learning with Skill Development and Retention

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    Due to the extreme measures taken to protect students from COVID-19 during the pandemic, schools closed their doors, and educators struggled to continue teaching through virtual learning platforms. Performance-based classrooms were encouraged to discover new methods and strategies to motivate students to thrive even though face-to-face rehearsals were restricted. This study examined the experiences secondary music education instrumentalists faced while attempting to utilize synchronous and asynchronous instruction in a 100 percent virtual performance-based environment. This study aimed to understand the negative and positive effects placed on secondary instrumentalists’ performance abilities, fundamental development, and participation/retention since the introduction of virtual learning in low-income areas. The focus of this study also examined the possible benefits of enhancing pedagogical skills through the addition of technological advances to push instrumental instruction and performances on the secondary level. This study followed a qualitative hermeneutic phenomenology design. Music educators in low-income DeKalb County communities were interviewed for this study. Participants were requested to share their perspectives and experiences of performance-based virtual learning and results. The study raised the need for future discussions to create and implement a state and national virtual music education guideline that would assist music educators in turning a devastating situation into a blessing for all art programs and their stakeholders

    Notas para un enfoque histórico – epistemológico de las tecnologías de la información y la comunicación

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    In this article, the author presents an analysis of the most recent information and communication technologies (ICT) and their influence on society. These ICT are constantly evolving, as they are designed, manufactured, and marketed continuously, creating pressure among consumers for the latest innovations and advances available in the market. Of note is the growing role these tools are playing in the educational arena, particularly at the primary level, where students learn about internet search, email, laptops, tablets, and other digital devices. This generation of students is commonly referred to as the “digital generation.” It is claimed that while children are taught to use these devices, they lack the technical knowledge to fully understand them. The intention of this study is to conduct a comprehensive analysis of this phenomenon from various perspectives, including the impact of ICT on society and its implications for academic education. To achieve this goal, the topic will be divided into several sub-themes that will be integrated in a cohesive way.  En este artículo, el autor presenta un análisis de las tecnologías de la información y la comunicación (TIC) más recientes y su influencia en la sociedad. Estas TIC están en constante evolución, debido a que se diseñan, fabrican y comercializan de forma continua, lo que genera presión entre los consumidores por obtener las innovaciones y los avances más recientes disponibles en el mercado. Cabe destacar el papel cada vez mayor que estas herramientas están desempeñando en el ámbito educativo, particularmente en el nivel primario, donde los estudiantes aprenden sobre la búsqueda en Internet, el correo electrónico, las computadoras portátiles, las tabletas y otros dispositivos digitales. Esta generación de estudiantes se conoce comúnmente como la «generación digital». Se afirma que, si bien a los niños se les enseña a usar estos dispositivos, carecen de los conocimientos técnicos necesarios para comprenderlos plenamente. La intención de este estudio es realizar un análisis exhaustivo de este fenómeno desde varias perspectivas, incluido el impacto de las TIC en la sociedad y sus implicaciones para la educación académica. Para lograr este objetivo, el tema se dividirá en varios subtemas que se integrarán de forma cohesionada

    Informationsströme in digitalen Kulturen

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    Wir sind umgeben von einer Vielzahl an Informationsströmen, die uns selbstverständlich erscheinen. Um diese digitalen Kulturen zu beschreiben, entwickeln medienwissenschaftliche Arbeiten Theorien einer Welt im Fluss. Dabei erliegen ihre Diagnosen oftmals einem Technikfetisch und vernachlässigen gesellschaftliche Strukturen. Mathias Denecke legt eine systematische Kritik dieser Theoriebildung vor. Dazu zeichnet er die Geschichte der Rede von strömenden Informationen in der Entwicklung digitaler Computer nach und diskutiert, wie der Begriff für Gegenwartsbeschreibungen produktiv gemacht werden kann

    An exploratory investigation on HOT English university courses during 2020 and 2021

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    openMany researchers have claimed that Here or There (HOT) Instruction might be a useful medium for educational purposes, such as English language classes. This dissertation tries to build a theoric framework within the HOT studies, and a questionnaire for both students and teachers was delivered to unveil new aspects of this medium
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