Autonomic care platform for optimizing query performance

Background: As the amount of information in electronic health care systems increases, data operations get more complicated and time-consuming. Intensive Care platforms require a timely processing of data retrievals to guarantee the continuous display of recent data of patients. Physicians and nurses rely on this data for their decision making. Manual optimization of query executions has become difficult to handle due to the increased amount of queries across multiple sources. Hence, a more automated management is necessary to increase the performance of database queries. The autonomic computing paradigm promises an approach in which the system adapts itself and acts as self-managing entity, thereby limiting human interventions and taking actions. Despite the usage of autonomic control loops in network and software systems, this approach has not been applied so far for health information systems. Methods: We extend the COSARA architecture, an infection surveillance and antibiotic management service platform for the Intensive Care Unit (ICU), with self-managed components to increase the performance of data retrievals. We used real-life ICU COSARA queries to analyse slow performance and measure the impact of optimizations. Each day more than 2 million COSARA queries are executed. Three control loops, which monitor the executions and take action, have been proposed: reactive, deliberative and reflective control loops. We focus on improvements of the execution time of microbiology queries directly related to the visual displays of patients' data on the bedside screens. Results: The results show that autonomic control loops are beneficial for the optimizations in the data executions in the ICU. The application of reactive control loop results in a reduction of 8.61% of the average execution time of microbiology results. The combined application of the reactive and deliberative control loop results in an average query time reduction of 10.92% and the combination of reactive, deliberative and reflective control loops provides a reduction of 13.04%. Conclusions: We found that by controlled reduction of queries' executions the performance for the end-user can be improved. The implementation of autonomic control loops in an existing health platform, COSARA, has a positive effect on the timely data visualization for the physician and nurse

Efficient Implementation of Stochastic Inference on Heterogeneous Clusters and Spiking Neural Networks

Neuromorphic computing refers to brain inspired algorithms and architectures. This paradigm of computing can solve complex problems which were not possible with traditional computing methods. This is because such implementations learn to identify the required features and classify them based on its training, akin to how brains function. This task involves performing computation on large quantities of data. With this inspiration, a comprehensive multi-pronged approach is employed to study and efficiently implement neuromorphic inference model using heterogeneous clusters to address the problem using traditional Von Neumann architectures and by developing spiking neural networks (SNN) for native and ultra-low power implementation. In this regard, an extendable high-performance computing (HPC) framework and optimizations are proposed for heterogeneous clusters to modularize complex neuromorphic applications in a distributed manner. To achieve best possible throughput and load balancing for such modularized architectures a set of algorithms are proposed to suggest the optimal mapping of different modules as an asynchronous pipeline to the available cluster resources while considering the complex data dependencies between stages. On the other hand, SNNs are more biologically plausible and can achieve ultra-low power implementation due to its sparse spike based communication, which is possible with emerging non-Von Neumann computing platforms. As a significant progress in this direction, spiking neuron models capable of distributed online learning are proposed. A high performance SNN simulator (SpNSim) is developed for simulation of large scale mixed neuron model networks. An accompanying digital hardware neuron RTL is also proposed for efficient real time implementation of SNNs capable of online learning. Finally, a methodology for mapping probabilistic graphical model to off-the-shelf neurosynaptic processor (IBM TrueNorth) as a stochastic SNN is presented with ultra-low power consumption