Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates

The study of cerebral anatomy in developing neonates is of great importance for the understanding of brain development during the early period of life. This dissertation therefore focuses on three challenges in the modelling of cerebral anatomy in neonates during brain development. The methods that have been developed all use Magnetic Resonance Images (MRI) as source data. To facilitate study of vascular development in the neonatal period, a set of image analysis algorithms are developed to automatically extract and model cerebral vessel trees. The whole process consists of cerebral vessel tracking from automatically placed seed points, vessel tree generation, and vasculature registration and matching. These algorithms have been tested on clinical Time-of- Flight (TOF) MR angiographic datasets. To facilitate study of the neonatal cortex a complete cerebral cortex segmentation and reconstruction pipeline has been developed. Segmentation of the neonatal cortex is not effectively done by existing algorithms designed for the adult brain because the contrast between grey and white matter is reversed. This causes pixels containing tissue mixtures to be incorrectly labelled by conventional methods. The neonatal cortical segmentation method that has been developed is based on a novel expectation-maximization (EM) method with explicit correction for mislabelled partial volume voxels. Based on the resulting cortical segmentation, an implicit surface evolution technique is adopted for the reconstruction of the cortex in neonates. The performance of the method is investigated by performing a detailed landmark study. To facilitate study of cortical development, a cortical surface registration algorithm for aligning the cortical surface is developed. The method first inflates extracted cortical surfaces and then performs a non-rigid surface registration using free-form deformations (FFDs) to remove residual alignment. Validation experiments using data labelled by an expert observer demonstrate that the method can capture local changes and follow the growth of specific sulcus

Edge Potential Functions (EPF) and Genetic Algorithms (GA) for Edge-Based Matching of Visual Objects

Edges are known to be a semantically rich representation of the contents of a digital image. Nevertheless, their use in practical applications is sometimes limited by computation and complexity constraints. In this paper, a new approach is presented that addresses the problem of matching visual objects in digital images by combining the concept of Edge Potential Functions (EPF) with a powerful matching tool based on Genetic Algorithms (GA). EPFs can be easily calculated starting from an edge map and provide a kind of attractive pattern for a matching contour, which is conveniently exploited by GAs. Several tests were performed in the framework of different image matching applications. The results achieved clearly outline the potential of the proposed method as compared to state of the art methodologies. (c) 2007 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works

Fiber-Flux Diffusion Density for White Matter Tracts Analysis: Application to Mild Anomalies Localization in Contact Sports Players

We present the concept of fiber-flux density for locally quantifying white matter (WM) fiber bundles. By combining scalar diffusivity measures (e.g., fractional anisotropy) with fiber-flux measurements, we define new local descriptors called Fiber-Flux Diffusion Density (FFDD) vectors. Applying each descriptor throughout fiber bundles allows along-tract coupling of a specific diffusion measure with geometrical properties, such as fiber orientation and coherence. A key step in the proposed framework is the construction of an FFDD dissimilarity measure for sub-voxel alignment of fiber bundles, based on the fast marching method (FMM). The obtained aligned WM tract-profiles enable meaningful inter-subject comparisons and group-wise statistical analysis. We demonstrate our method using two different datasets of contact sports players. Along-tract pairwise comparison as well as group-wise analysis, with respect to non-player healthy controls, reveal significant and spatially-consistent FFDD anomalies. Comparing our method with along-tract FA analysis shows improved sensitivity to subtle structural anomalies in football players over standard FA measurements

Multi-View Image Compositions

The geometry of single-viewpoint panoramas is well understood: multiple pictures taken from the same viewpoint may be stitched together into a consistent panorama mosaic. By contrast, when the point of view changes or when the scene changes (e.g., due to objects moving) no consistent mosaic may be obtained, unless the structure of the scene is very special. Artists have explored this problem and demonstrated that geometrical consistency is not the only criterion for success: incorporating multiple view points in space and time into the same panorama may produce compelling and informative pictures. We explore this avenue and suggest an approach to automating the construction of mosaics from images taken from multiple view points into a single panorama. Rather than looking at 3D scene consistency we look at image consistency. Our approach is based on optimizing a cost function that keeps into account image-to-image consistency which is measured on point-features and along picture boundaries. The optimization explicitly considers occlusion between pictures. We illustrate our ideas with a number of experiments on collections of images of objects and outdoor scenes

GeoSay: A Geometric Saliency for Extracting Buildings in Remote Sensing Images

Automatic extraction of buildings in remote sensing images is an important but challenging task and finds many applications in different fields such as urban planning, navigation and so on. This paper addresses the problem of buildings extraction in very high-spatial-resolution (VHSR) remote sensing (RS) images, whose spatial resolution is often up to half meters and provides rich information about buildings. Based on the observation that buildings in VHSR-RS images are always more distinguishable in geometry than in texture or spectral domain, this paper proposes a geometric building index (GBI) for accurate building extraction, by computing the geometric saliency from VHSR-RS images. More precisely, given an image, the geometric saliency is derived from a mid-level geometric representations based on meaningful junctions that can locally describe geometrical structures of images. The resulting GBI is finally measured by integrating the derived geometric saliency of buildings. Experiments on three public and commonly used datasets demonstrate that the proposed GBI achieves the state-of-the-art performance and shows impressive generalization capability. Additionally, GBI preserves both the exact position and accurate shape of single buildings compared to existing methods

Airborne photogrammetry and LIDAR for DSM extraction and 3D change detection over an urban area : a comparative study

A digital surface model (DSM) extracted from stereoscopic aerial images, acquired in March 2000, is compared with a DSM derived from airborne light detection and ranging (lidar) data collected in July 2009. Three densely built-up study areas in the city centre of Ghent, Belgium, are selected, each covering approximately 0.4 km(2). The surface models, generated from the two different 3D acquisition methods, are compared qualitatively and quantitatively as to what extent they are suitable in modelling an urban environment, in particular for the 3D reconstruction of buildings. Then the data sets, which are acquired at two different epochs t(1) and t(2), are investigated as to what extent 3D (building) changes can be detected and modelled over the time interval. A difference model, generated by pixel-wise subtracting of both DSMs, indicates changes in elevation. Filters are proposed to differentiate 'real' building changes from false alarms provoked by model noise, outliers, vegetation, etc. A final 3D building change model maps all destructed and newly constructed buildings within the time interval t(2) - t(1). Based on the change model, the surface and volume of the building changes can be quantified

Fuzzy geometry, entropy, and image information

Presented here are various uncertainty measures arising from grayness ambiguity and spatial ambiguity in an image, and their possible applications as image information measures. Definitions are given of an image in the light of fuzzy set theory, and of information measures and tools relevant for processing/analysis e.g., fuzzy geometrical properties, correlation, bound functions and entropy measures. Also given is a formulation of algorithms along with management of uncertainties for segmentation and object extraction, and edge detection. The output obtained here is both fuzzy and nonfuzzy. Ambiguity in evaluation and assessment of membership function are also described