A Survey on Deep Learning in Medical Image Analysis

Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images. This paper reviews the major deep learning concepts pertinent to medical image analysis and summarizes over 300 contributions to the field, most of which appeared in the last year. We survey the use of deep learning for image classification, object detection, segmentation, registration, and other tasks and provide concise overviews of studies per application area. Open challenges and directions for future research are discussed.Comment: Revised survey includes expanded discussion section and reworked introductory section on common deep architectures. Added missed papers from before Feb 1st 201

Deep Learning in Cardiology

The medical field is creating large amount of data that physicians are unable to decipher and use efficiently. Moreover, rule-based expert systems are inefficient in solving complicated medical tasks or for creating insights using big data. Deep learning has emerged as a more accurate and effective technology in a wide range of medical problems such as diagnosis, prediction and intervention. Deep learning is a representation learning method that consists of layers that transform the data non-linearly, thus, revealing hierarchical relationships and structures. In this review we survey deep learning application papers that use structured data, signal and imaging modalities from cardiology. We discuss the advantages and limitations of applying deep learning in cardiology that also apply in medicine in general, while proposing certain directions as the most viable for clinical use.Comment: 27 pages, 2 figures, 10 table

Detailing patient specific modelling to aid clinical decision-making

The anatomy of the craniofacial skeleton has been described through the aid of dissection identifying hard and soft tissue structures. Although the macro and microscopic investigation of internal facial tissues have provided invaluable information on constitution of the tissues it is important to inspect and model facial tissues in the living individual. Detailing the form and function of facial tissues will be invaluable in clinical diagnoses and planned corrective surgical interventions such as management of facial palsies and craniofacial disharmony/anomalies. Recent advances in lower-cost, non-invasive imaging and computing power (surface scanning, Cone Beam Computerized Tomography (CBCT) and Magnetic Resonance (MRI)) has enabled the ability to capture and process surface and internal structures to a high resolution. The three-dimensional surface facial capture has enabled characterization of facial features all of which will influence subtleties in facial movement and surgical planning. This chapter will describe the factors that influence facial morphology in terms of gender and age differences, facial movement—surface and underlying structures, modeling based on average structures, orientation of facial muscle fibers, biomechanics of movement—proof of principle and surgical intervention

Structure fusion based on graph convolutional networks for semi-supervised classification

Suffering from the multi-view data diversity and complexity for semi-supervised classification, most of existing graph convolutional networks focus on the networks architecture construction or the salient graph structure preservation, and ignore the the complete graph structure for semi-supervised classification contribution. To mine the more complete distribution structure from multi-view data with the consideration of the specificity and the commonality, we propose structure fusion based on graph convolutional networks (SF-GCN) for improving the performance of semi-supervised classification. SF-GCN can not only retain the special characteristic of each view data by spectral embedding, but also capture the common style of multi-view data by distance metric between multi-graph structures. Suppose the linear relationship between multi-graph structures, we can construct the optimization function of structure fusion model by balancing the specificity loss and the commonality loss. By solving this function, we can simultaneously obtain the fusion spectral embedding from the multi-view data and the fusion structure as adjacent matrix to input graph convolutional networks for semi-supervised classification. Experiments demonstrate that the performance of SF-GCN outperforms that of the state of the arts on three challenging datasets, which are Cora,Citeseer and Pubmed in citation networks

Feature Driven Learning Techniques for 3D Shape Segmentation

Segmentation is a fundamental problem in 3D shape analysis and machine learning. The abil-ity to partition a 3D shape into meaningful or functional parts is a vital ingredient of many down stream applications like shape matching, classification and retrieval. Early segmentation methods were based on approaches like fitting primitive shapes to parts or extracting segmen-tations from feature points. However, such methods had limited success on shapes with more complex geometry. Observing this, research began using geometric features to aid the segmen-tation, as certain features (e.g. Shape Diameter Function (SDF)) are less sensitive to complex geometry. This trend was also incorporated in the shift to set-wide segmentations, called co-segmentation, which provides a consistent segmentation throughout a shape dataset, meaning similar parts have the same segment identifier. The idea of co-segmentation is that a set of same class shapes (i.e. chairs) contain more information about the class than a single shape would, which could lead to an overall improvement to the segmentation of the individual shapes. Over the past decade many different approaches of co-segmentation have been explored covering supervised, unsupervised and even user-driven active learning. In each of the areas, there has been widely adopted use of geometric features to aid proposed segmentation algorithms, with each method typically using different combinations of features. The aim of this thesis is to ex-plore these different areas of 3D shape segmentation, perform an analysis of the effectiveness of geometric features in these areas and tackle core issues that currently exist in the literature.Initially, we explore the area of unsupervised segmentation, specifically looking at co-segmentation, and perform an analysis of several different geometric features. Our analysis is intended to compare the different features in a single unsupervised pipeline to evaluate their usefulness and determine their strengths and weaknesses. Our analysis also includes several features that have not yet been explored in unsupervised segmentation but have been shown effective in other areas.Later, with the ever increasing popularity of deep learning, we explore the area of super-vised segmentation and investigate the current state of Neural Network (NN) driven techniques. We specifically observe limitations in the current state-of-the-art and propose a novel Convolu-tional Neural Network (CNN) based method which operates on multi-scale geometric features to gain more information about the shapes being segmented. We also perform an evaluation of several different supervised segmentation methods using the same input features, but with vary-ing complexity of model design. This is intended to see if the more complex models provide a significant performance increase.Lastly, we explore the user-driven area of active learning, to tackle the large amounts of inconsistencies in current ground truth segmentation, which are vital for most segmentation methods. Active learning has been used to great effect for ground truth generation in the past, so we present a novel active learning framework using deep learning and geometric features to assist the user in co-segmentation of a dataset. Our method emphasises segmentation accu-racy while minimising user effort, providing an interactive visualisation for co-segmentation analysis and the application of automated optimisation tools.In this thesis we explore the effectiveness of different geometric features across varying segmentation tasks, providing an in-depth analysis and comparison of state-of-the-art methods