Automated 5-year Mortality Prediction using Deep Learning and Radiomics Features from Chest Computed Tomography

We propose new methods for the prediction of 5-year mortality in elderly individuals using chest computed tomography (CT). The methods consist of a classifier that performs this prediction using a set of features extracted from the CT image and segmentation maps of multiple anatomic structures. We explore two approaches: 1) a unified framework based on deep learning, where features and classifier are automatically learned in a single optimisation process; and 2) a multi-stage framework based on the design and selection/extraction of hand-crafted radiomics features, followed by the classifier learning process. Experimental results, based on a dataset of 48 annotated chest CTs, show that the deep learning model produces a mean 5-year mortality prediction accuracy of 68.5%, while radiomics produces a mean accuracy that varies between 56% to 66% (depending on the feature selection/extraction method and classifier). The successful development of the proposed models has the potential to make a profound impact in preventive and personalised healthcare.Comment: 9 page

Deep-Learning-Based Computer- Aided Systems for Breast Cancer Imaging: A Critical Review

[EN] This paper provides a critical review of the literature on deep learning applications in breast tumor diagnosis using ultrasound and mammography images. It also summarizes recent advances in computer-aided diagnosis/detection (CAD) systems, which make use of new deep learning methods to automatically recognize breast images and improve the accuracy of diagnoses made by radiologists. This review is based upon published literature in the past decade (January 2010-January 2020), where we obtained around 250 research articles, and after an eligibility process, 59 articles were presented in more detail. The main findings in the classification process revealed that new DL-CAD methods are useful and effective screening tools for breast cancer, thus reducing the need for manual feature extraction. The breast tumor research community can utilize this survey as a basis for their current and future studies.This project has been co-financed by the Spanish Government Grant PID2019-107790RB-C22, "Software development for a continuous PET crystal systems applied to breast cancer".Jiménez-Gaona, Y.; Rodríguez Álvarez, MJ.; Lakshminarayanan, V. (2020). Deep-Learning-Based Computer- Aided Systems for Breast Cancer Imaging: A Critical Review. Applied Sciences. 10(22):1-29. https://doi.org/10.3390/app10228298S1291022Jemal, A., Bray, F., Center, M. M., Ferlay, J., Ward, E., & Forman, D. (2011). Global cancer statistics. CA: A Cancer Journal for Clinicians, 61(2), 69-90. doi:10.3322/caac.20107Gao, F., Chia, K.-S., Ng, F.-C., Ng, E.-H., & Machin, D. (2002). Interval cancers following breast cancer screening in Singaporean women. International Journal of Cancer, 101(5), 475-479. doi:10.1002/ijc.10636Munir, K., Elahi, H., Ayub, A., Frezza, F., & Rizzi, A. (2019). 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Deep learning approach for breast cancer diagnosis

Breast cancer is one of the leading fatal disease worldwide with high risk control if early discovered. Conventional method for breast screening is x-ray mammography, which is known to be challenging for early detection of cancer lesions. The dense breast structure produced due to the compression process during imaging lead to difficulties to recognize small size abnormalities. Also, inter- and intra-variations of breast tissues lead to significant difficulties to achieve high diagnosis accuracy using hand-crafted features. Deep learning is an emerging machine learning technology that requires a relatively high computation power. Yet, it proved to be very effective in several difficult tasks that requires decision making at the level of human intelligence. In this paper, we develop a new network architecture inspired by the U-net structure that can be used for effective and early detection of breast cancer. Results indicate a high rate of sensitivity and specificity that indicate potential usefulness of the proposed approach in clinical use

Improving Workflow Efficiency for Mammography Using Machine Learning.

OBJECTIVE: The aim of this study was to determine whether machine learning could reduce the number of mammograms the radiologist must read by using a machine-learning classifier to correctly identify normal mammograms and to select the uncertain and abnormal examinations for radiological interpretation. METHODS: Mammograms in a research data set from over 7,000 women who were recalled for assessment at six UK National Health Service Breast Screening Program centers were used. A convolutional neural network in conjunction with multitask learning was used to extract imaging features from mammograms that mimic the radiological assessment provided by a radiologist, the patient's nonimaging features, and pathology outcomes. A deep neural network was then used to concatenate and fuse multiple mammogram views to predict both a diagnosis and a recommendation of whether or not additional radiological assessment was needed. RESULTS: Ten-fold cross-validation was used on 2,000 randomly selected patients from the data set; the remainder of the data set was used for convolutional neural network training. While maintaining an acceptable negative predictive value of 0.99, the proposed model was able to identify 34% (95% confidence interval, 25%-43%) and 91% (95% confidence interval: 88%-94%) of the negative mammograms for test sets with a cancer prevalence of 15% and 1%, respectively. CONCLUSION: Machine learning was leveraged to successfully reduce the number of normal mammograms that radiologists need to read without degrading diagnostic accuracy

Breast Cancer Classification using Deep Learned Features Boosted with Handcrafted Features

Breast cancer is one of the leading causes of death among women across the globe. It is difficult to treat if detected at advanced stages, however, early detection can significantly increase chances of survival and improves lives of millions of women. Given the widespread prevalence of breast cancer, it is of utmost importance for the research community to come up with the framework for early detection, classification and diagnosis. Artificial intelligence research community in coordination with medical practitioners are developing such frameworks to automate the task of detection. With the surge in research activities coupled with availability of large datasets and enhanced computational powers, it expected that AI framework results will help even more clinicians in making correct predictions. In this article, a novel framework for classification of breast cancer using mammograms is proposed. The proposed framework combines robust features extracted from novel Convolutional Neural Network (CNN) features with handcrafted features including HOG (Histogram of Oriented Gradients) and LBP (Local Binary Pattern). The obtained results on CBIS-DDSM dataset exceed state of the art