Automagically Encoding Adverse Drug Reactions in MedDRA

Abstract-Pharmacovigilance is the field of science devoted to the collection, analysis, and prevention of Adverse Drug Reactions (ADRs). Efficient strategies for the extraction of information about ADRs from free text sources are essential to support the important task of detecting and classifying unexpected pathologies, possibly related to (therapy-related) drug use. Narrative ADR descriptions may be collected in different ways, e.g., either by monitoring social networks or through the so called "spontaneous reporting, the main method pharmacovigilance adopts in order to identify ADRs. The encoding of free-text ADR descriptions according to MedDRA standard terminology is central for report analysis. It is a complex work, which has to be manually implemented by the pharmacovigilance experts. The manual encoding is expensive (in terms of time). Moreover, a problem about the accuracy of the encoding may occur, since the number of reports is growing up day by day. In this paper, we propose MagiCoder, an efficient Natural Language Processing algorithm able to automatically derive MedDRA terminologies from freetext ADR descriptions. MagiCoder is part of VigiWork, a web application for online ADR reporting and analysis. From a practical point of view, MagiCoder reduces the encoding time of ADR reports. Pharmacologists have simply to review and validate the MedDRA terms proposed by MagiCoder, instead of choosing the right terms among the 70K terms of MedDRA. Such improvement in the efficiency of pharmacologists' work has a relevant impact also on the quality of the following data analysis. Our proposal is based on a general approach, not depending on the considered language. Indeed, we developed MagiCoder for the Italian pharmacovigilance language, but preliminarily analyses show that it is robust to language and dictionary changes

a simple algorithm for the lexical classification of comparable adjectives

Abstract Lexical classification is one of the most widely investigated fields in (computational) linguistic and Natural language Processing. Adjectives play a significant role both in classification tasks and in applications as sentiment analysis. In this paper a simple algorithm for lexical classification of comparable adjectives, called MORE (coMparable fORm dEtector), is proposed. The algorithm is efficient in time. The method is a specific unsupervised learning technique. Results are verified against a reference standard built from 80 manually annotated lists of adjective. The algorithm exhibits an accuracy of 76%

Protecting the environment: A multi-agent approach to environmental monitoring

In this paper we discuss a transition model from commonly adopted models of data gathering, transfer and management for environmental monitoring towards more sophisticated ones based on Artificial Intelligence and IoT. The transition model is based on the paradigm of multiple agent systems. The adoption of this transition model is motivated by the need to improve effectiveness, efficiency and interoperability of environmental monitoring by simultaneously guaranteeing its sustainability in economic term

From narrative descriptions to MedDRA: automagically encoding adverse drug reactions

The collection of narrative spontaneous reports is an irreplaceable source for the prompt detection of suspected adverse drug reactions (ADRs). In such task qualified domain experts manually revise a huge amount of narrative descriptions and then encode texts according to MedDRA standard terminology. The manual annotation of narrative documents with medical terminology is a subtle and expensive task, since the number of reports is growing up day-by-day. Natural Language Processing (NLP) applications can support the work of people responsible for pharmacovigilance. Our objective is to develop NLP algorithms and tools for the detection of ADR clinical terminology. Efficient applications can concretely improve the quality of the experts\u2019 revisions. NLP software can quickly analyze narrative texts and offer an encoding (i.e., a list of MedDRA terms) that the expert has to revise and validate. MagiCoder, an NLP algorithm, is proposed for the automatic encoding of free-text descriptions into MedDRA terms. MagiCoder procedure is efficient in terms of computational complexity. We tested MagiCoder through several experiments. In the first one, we tested it on a large dataset of about 4500 manually revised reports, by performing an automated comparison between human and MagiCoder encoding. Moreover, we tested MagiCoder on a set of about 1800 reports, manually revised ex novo by some experts of the domain, who also compared automatic solutions with the gold reference standard. We also provide two initial experiments with reports written in English, giving a first evidence of the robustness of MagiCoder w.r.t. the change of the language. For the current base version of MagiCoder, we measured an average recall and precision of and , respectively. From a practical point of view, MagiCoder reduces the time required for encoding ADR reports. Pharmacologists have only to review and validate the MedDRA terms proposed by the application, instead of choosing the right terms among the 70\u202fK low level terms of MedDRA. Such improvement in the efficiency of pharmacologists\u2019 work has a relevant impact also on the quality of the subsequent data analysis. We developed MagiCoder for the Italian pharmacovigilance language. However, our proposal is based on a general approach, not depending on the considered language nor the term dictionary

Automagically Encoding Adverse Drug Reactions in MedDRA

Pharmacovigilance is the field of science devoted to the collection, analysis and prevention of Adverse Drug Reactions (ADRs). Efficient strategies for the extraction of information about ADRs from free text resources are essential to support the work of experts, employed in the crucial task of detecting and classifying unexpected pathologies possibly related to drug assumptions. Narrative ADR descriptions may be collected in several way, e.g. by monitoring social networks or through the so called spontaneous reporting, the main method pharmacovigi- lance adopts in order to identify ADRs. The encoding of free-text ADR descriptions according to MedDRA standard terminology is central for report analysis. It is a complex work, which has to be manually implemented by the pharmacovigilance experts. The manual encoding is expensive (in terms of time). Moreover, a problem about the accuracy of the encoding may occur, since the number of reports is growing up day by day. In this paper, we propose MagiCoder, an efficient Natural Language Processing al- gorithm able to automatically derive MedDRA terminologies from free-text ADR descriptions. MagiCoder is part of VigiWork, a web application for online ADR reporting and analysis. From a practical view-point, MagiCoder radically reduces the revision time of ADR reports: the pharmacologist has simply to revise and validate the automatic solution versus the hard task of choosing solutions in the 70k terms of MedDRA. This improvement of the expert work efficiency has a meaningful impact on the quality of data analysis. Moreover, our procedure is general purpose. We developed MagiCoder for the Italian pharmacovigilance language, but preliminarily analyses show that it is robust to language and dictionary changes