Pattern-matching with bounded gaps in genomic sequences

Recently, some pattern matching algorithms allowing gaps were introduced in Crochemore et al. [Approximate string matching with gaps. Nordic Journal of Computing, 9 (2002):54–65, 2002], where upper-bounded, strict-bounded and unbounded gaps were considered. In this paper we further extend these restrictions on the gaps to permit lower-bounded and (lower-upper)-bounded gaps that we simply refer to as (a,b)-bounded gaps. We give formal definitions for these problems as well as their respective algorithmic solutions

String Indexing for Patterns with Wildcards

We consider the problem of indexing a string $t$ of length $n$ to report the occurrences of a query pattern $p$ containing $m$ characters and $j$ wildcards. Let $occ$ be the number of occurrences of $p$ in $t$, and $\sigma$ the size of the alphabet. We obtain the following results. - A linear space index with query time $O(m+\sigma^j \log \log n + occ)$. This significantly improves the previously best known linear space index by Lam et al. [ISAAC 2007], which requires query time $\Theta(jn)$ in the worst case. - An index with query time $O(m+j+occ)$ using space $O(\sigma^{k^2} n \log^k \log n)$, where $k$ is the maximum number of wildcards allowed in the pattern. This is the first non-trivial bound with this query time. - A time-space trade-off, generalizing the index by Cole et al. [STOC 2004]. We also show that these indexes can be generalized to allow variable length gaps in the pattern. Our results are obtained using a novel combination of well-known and new techniques, which could be of independent interest

String Matching with Variable Length Gaps

We consider string matching with variable length gaps. Given a string $T$ and a pattern $P$ consisting of strings separated by variable length gaps (arbitrary strings of length in a specified range), the problem is to find all ending positions of substrings in $T$ that match $P$. This problem is a basic primitive in computational biology applications. Let $m$ and $n$ be the lengths of $P$ and $T$, respectively, and let $k$ be the number of strings in $P$. We present a new algorithm achieving time $O(n\log k + m +\alpha)$ and space $O(m + A)$, where $A$ is the sum of the lower bounds of the lengths of the gaps in $P$ and $\alpha$ is the total number of occurrences of the strings in $P$ within $T$. Compared to the previous results this bound essentially achieves the best known time and space complexities simultaneously. Consequently, our algorithm obtains the best known bounds for almost all combinations of $m$, $n$, $k$, $A$, and $\alpha$. Our algorithm is surprisingly simple and straightforward to implement. We also present algorithms for finding and encoding the positions of all strings in $P$ for every match of the pattern.Comment: draft of full version, extended abstract at SPIRE 201

Palindromic Decompositions with Gaps and Errors

Identifying palindromes in sequences has been an interesting line of research in combinatorics on words and also in computational biology, after the discovery of the relation of palindromes in the DNA sequence with the HIV virus. Efficient algorithms for the factorization of sequences into palindromes and maximal palindromes have been devised in recent years. We extend these studies by allowing gaps in decompositions and errors in palindromes, and also imposing a lower bound to the length of acceptable palindromes. We first present an algorithm for obtaining a palindromic decomposition of a string of length n with the minimal total gap length in time O(n log n * g) and space O(n g), where g is the number of allowed gaps in the decomposition. We then consider a decomposition of the string in maximal \delta-palindromes (i.e. palindromes with \delta errors under the edit or Hamming distance) and g allowed gaps. We present an algorithm to obtain such a decomposition with the minimal total gap length in time O(n (g + \delta)) and space O(n g).Comment: accepted to CSR 201

Finding approximate palindromes in strings

We introduce a novel definition of approximate palindromes in strings, and provide an algorithm to find all maximal approximate palindromes in a string with up to $k$ errors. Our definition is based on the usual edit operations of approximate pattern matching, and the algorithm we give, for a string of size $n$ on a fixed alphabet, runs in $O(k^2 n)$ time. We also discuss two implementation-related improvements to the algorithm, and demonstrate their efficacy in practice by means of both experiments and an average-case analysis