Multiple bottlenecks sorting criterion at initial sequence in solving permutation flow shop scheduling problem

This paper proposes a heuristic that introduces the application of bottleneck-based concept at the beginning of an initial sequence determination with the objective of makespan minimization. Earlier studies found that the scheduling activity become complicated when dealing with machine, m greater than 2, known as non-deterministic polynomial-time hardness (NP-hard). To date, the Nawaz-Enscore-Ham (NEH) algorithm is still recognized as the best heuristic in solving makespan problem in scheduling environment. Thus, this study treated the NEH heuristic as the highest ranking and most suitable heuristic for evaluation purpose since it is the best performing heuristic in makespan minimization. This study used the bottleneck-based approach to identify the critical processing machine which led to high completion time. In this study, an experiment involving machines (m =4) and n-job (n = 6, 10, 15, 20) was simulated in Microsoft Excel Simple Programming to solve the permutation flowshop scheduling problem. The overall computational results demonstrated that the bottleneck machine M4 performed the best in minimizing the makespan for all data set of problems

A novel multivariate STeady-state index during general ANesthesia (STAN)

The assessment of the adequacy of general anesthesia for surgery, namely the nociception/anti-nociception balance, has received wide attention from the scientific community. Monitoring systems based on the frontal EEG/EMG, or autonomic state reactions (e.g. heart rate and blood pressure) have been developed aiming to objectively assess this balance. In this study a new multivariate indicator of patients' steady-state during anesthesia (STAN) is proposed, based on wavelet analysis of signals linked to noxious activation. A clinical protocol was designed to analyze precise noxious stimuli (laryngoscopy/intubation, tetanic, and incision), under three different analgesic doses; patients were randomized to receive either remifentanil 2.0, 3.0 or 4.0 ng/ml. ECG, PPG, BP, BIS, EMG and [Formula: see text] were continuously recorded. ECG, PPG and BP were processed to extract beat-to-beat information, and [Formula: see text] curve used to estimate the respiration rate. A combined steady-state index based on wavelet analysis of these variables, was applied and compared between the three study groups and stimuli (Wilcoxon signed ranks, Kruskal-Wallis and Mann-Whitney tests). Following institutional approval and signing the informed consent thirty four patients were enrolled in this study (3 excluded due to signal loss during data collection). The BIS index of the EEG, frontal EMG, heart rate, BP, and PPG wave amplitude changed in response to different noxious stimuli. Laryngoscopy/intubation was the stimulus with the more pronounced response [Formula: see text]. These variables were used in the construction of the combined index STAN; STAN responded adequately to noxious stimuli, with a more pronounced response to laryngoscopy/intubation (18.5-43.1 %, [Formula: see text]), and the attenuation provided by the analgesic, detecting steady-state periods in the different physiological signals analyzed (approximately 50 % of the total study time). A new multivariate approach for the assessment of the patient steady-state during general anesthesia was developed. The proposed wavelet based multivariate index responds adequately to different noxious stimuli, and attenuation provided by the analgesic in a dose-dependent manner for each stimulus analyzed in this study.The first author was supported by a scholarship from the Portuguese Foundation for Science and Technology (FCT SFRH/BD/35879/2007). The authors would also like to acknowledge the support of UISPA—System Integration and Process Automation Unit—Part of the LAETA (Associated Laboratory of Energy, Transports and Aeronautics) a I&D Unit of the Foundation for Science and Technology (FCT), Portugal. FCT support under project PEst-OE/EME/LA0022/2013.info:eu-repo/semantics/publishedVersio

Diagnosis of a unit-wide disturbance caused by saturation in a manipulated variable

It is well known that faulty control valves with friction in the moving parts lead to limit cycle oscillations which can propagate to other parts of the plant. However, a control loop with healthy valve can also undergo oscillatory behavior. The root cause of a unit-wide oscillation in a distillation column was traced to a pressure control loop in a case study at Mitsui Chemicals. The diagnosis was made by means of a new technique of pattern matching of the time-resolved frequency spectrum using a wavelet analysis tool. The method identified key characteristics shared by measurements at various places in the column and quantified the similarities. Non-linearity was detected in the time trend of the pressure measurement, a result which initially suggested the root cause was a faulty actuator or sensor. Further analysis showed, however, that the source of non-linearlity was periodic saturation of the manipulated variable caused by slack tuning. The problem was remidied by changing the controller tuning settings and the unit-wide disturbance then went away