4 research outputs found
Antifragility Predicts the Robustness and Evolvability of Biological Networks through Multi-class Classification with a Convolutional Neural Network
Robustness and evolvability are essential properties to the evolution of
biological networks. To determine if a biological network is robust and/or
evolvable, it is required to compare its functions before and after mutations.
However, this sometimes takes a high computational cost as the network size
grows. Here we develop a predictive method to estimate the robustness and
evolvability of biological networks without an explicit comparison of
functions. We measure antifragility in Boolean network models of biological
systems and use this as the predictor. Antifragility occurs when a system
benefits from external perturbations. By means of the differences of
antifragility between the original and mutated biological networks, we train a
convolutional neural network (CNN) and test it to classify the properties of
robustness and evolvability. We found that our CNN model successfully
classified the properties. Thus, we conclude that our antifragility measure can
be used as a predictor of the robustness and evolvability of biological
networks.Comment: 22 pages, 10 figure
Stocks and Cryptocurrencies: Anti-fragile or Robust?
Antifragility was recently defined as a property of complex systems that
benefit from disorder. However, its original formal definition is difficult to
apply. Our approach has been to define and test a much simpler measure of
antifragility for complex systems. In this work we use our antifragility
measure to analyze real data from the stock market and cryptocurrency prices.
Results vary between different antifragility interpretations and for each
system. Our results suggest that the stock market favors robustness rather than
antifragility, as in most cases the highest and lowest antifragility values are
reached either by young agents or constant ones. There are no clear
correlations between antifragility and different good-performance measures,
while the best performers seem to fall within a robust threshold. In the case
of cryptocurrencies, there is an apparent correlation between high price and
high antifragility.Comment: 11 pages, 5 figure
Thermodynamic optimization subsumed in stability phenomena
[EN]In the present paper the possibility of an energetic self-optimization as a consequence of
thermodynamic stability is addressed. This feature is analyzed in a low dissipation refrigerator
working in an optimized trade-off regime (the so-called Omega function). The relaxation after a
perturbation around the stable point indicates that stability is linked to trajectories in which the
thermodynamic performance is improved. Furthermore, a limited control over the system is analyzed
through consecutive external random perturbations. The statistics over many cycles corroborates the
preference for a better thermodynamic performance. Endoreversible and irreversible behaviors play
a relevant role in the relaxation trajectories (as well as in the statistical performance of many cycles
experiencing random perturbations). A multi-objective optimization reveals that the well-known
endoreversible limit works as an attractor of the system evolution coinciding with the Pareto front,
which represents the best energetic compromise among efficiency, entropy generation, cooling
power, input power and the Omega function. Meanwhile, near the stable state, performance and
stability are dominated by an irreversible behavior
Towards an engineering theory of evolution
Effective biological engineering requires the acknowledgement of evolution and its consideration during the design process. In this perspective, the authors present the concept of the evotype to reason about and shape the evolutionary potential of natural and engineered biosystems