Efficient deep processing of japanese

We present a broad coverage Japanese grammar written in the HPSG formalism with MRS semantics. The grammar is created for use in real world applications, such that robustness and performance issues play an important role. It is connected to a POS tagging and word segmentation tool. This grammar is being developed in a multilingual context, requiring MRS structures that are easily comparable across languages

Carbohydrate-derived amphiphilic macromolecules: a biophysical structural characterization and analysis of binding behaviors to model membranes.

The design and synthesis of enhanced membrane-intercalating biomaterials for drug delivery or vascular membrane targeting is currently challenged by the lack of screening and prediction tools. The present work demonstrates the generation of a Quantitative Structural Activity Relationship model (QSAR) to make a priori predictions. Amphiphilic macromolecules (AMs) "stealth lipids" built on aldaric and uronic acids frameworks attached to poly(ethylene glycol) (PEG) polymer tails were developed to form self-assembling micelles. In the present study, a defined set of novel AM structures were investigated in terms of their binding to lipid membrane bilayers using Quartz Crystal Microbalance with Dissipation (QCM-D) experiments coupled with computational coarse-grained molecular dynamics (CG MD) and all-atom MD (AA MD) simulations. The CG MD simulations capture the insertion dynamics of the AM lipophilic backbones into the lipid bilayer with the PEGylated tail directed into bulk water. QCM-D measurements with Voigt viscoelastic model analysis enabled the quantitation of the mass gain and rate of interaction between the AM and the lipid bilayer surface. Thus, this study yielded insights about variations in the functional activity of AM materials with minute compositional or stereochemical differences based on membrane binding, which has translational potential for transplanting these materials in vivo. More broadly, it demonstrates an integrated computational-experimental approach, which can offer a promising strategy for the in silico design and screening of therapeutic candidate materials

Heap Abstractions for Static Analysis

Heap data is potentially unbounded and seemingly arbitrary. As a consequence, unlike stack and static memory, heap memory cannot be abstracted directly in terms of a fixed set of source variable names appearing in the program being analysed. This makes it an interesting topic of study and there is an abundance of literature employing heap abstractions. Although most studies have addressed similar concerns, their formulations and formalisms often seem dissimilar and some times even unrelated. Thus, the insights gained in one description of heap abstraction may not directly carry over to some other description. This survey is a result of our quest for a unifying theme in the existing descriptions of heap abstractions. In particular, our interest lies in the abstractions and not in the algorithms that construct them. In our search of a unified theme, we view a heap abstraction as consisting of two features: a heap model to represent the heap memory and a summarization technique for bounding the heap representation. We classify the models as storeless, store based, and hybrid. We describe various summarization techniques based on k-limiting, allocation sites, patterns, variables, other generic instrumentation predicates, and higher-order logics. This approach allows us to compare the insights of a large number of seemingly dissimilar heap abstractions and also paves way for creating new abstractions by mix-and-match of models and summarization techniques.Comment: 49 pages, 20 figure

Robust Machine Learning-Based Correction on Automatic Segmentation of the Cerebellum and Brainstem.

Automated segmentation is a useful method for studying large brain structures such as the cerebellum and brainstem. However, automated segmentation may lead to inaccuracy and/or undesirable boundary. The goal of the present study was to investigate whether SegAdapter, a machine learning-based method, is useful for automatically correcting large segmentation errors and disagreement in anatomical definition. We further assessed the robustness of the method in handling size of training set, differences in head coil usage, and amount of brain atrophy. High resolution T1-weighted images were acquired from 30 healthy controls scanned with either an 8-channel or 32-channel head coil. Ten patients, who suffered from brain atrophy because of fragile X-associated tremor/ataxia syndrome, were scanned using the 32-channel head coil. The initial segmentations of the cerebellum and brainstem were generated automatically using Freesurfer. Subsequently, Freesurfer's segmentations were both manually corrected to serve as the gold standard and automatically corrected by SegAdapter. Using only 5 scans in the training set, spatial overlap with manual segmentation in Dice coefficient improved significantly from 0.956 (for Freesurfer segmentation) to 0.978 (for SegAdapter-corrected segmentation) for the cerebellum and from 0.821 to 0.954 for the brainstem. Reducing the training set size to 2 scans only decreased the Dice coefficient ≤0.002 for the cerebellum and ≤ 0.005 for the brainstem compared to the use of training set size of 5 scans in corrective learning. The method was also robust in handling differences between the training set and the test set in head coil usage and the amount of brain atrophy, which reduced spatial overlap only by <0.01. These results suggest that the combination of automated segmentation and corrective learning provides a valuable method for accurate and efficient segmentation of the cerebellum and brainstem, particularly in large-scale neuroimaging studies, and potentially for segmenting other neural regions as well

First anatomical network analysis of fore- and hindlimb musculoskeletal modularity in bonobos, common chimpanzees, and humans

Studies of morphological integration and modularity, and of anatomical complexity in human evolution typically focus on skeletal tissues. Here we provide the first network analysis of the musculoskeletal anatomy of both the fore- and hindlimbs of the two species of chimpanzee and humans. Contra long-accepted ideas, network analysis reveals that the hindlimb displays a pattern opposite to that of the forelimb: Pan big toe is typically seen as more independently mobile, but humans are actually the ones that have a separate module exclusively related to its movements. Different fore- vs hindlimb patterns are also seen for anatomical network complexity (i.e., complexity in the arrangement of bones and muscles). For instance, the human hindlimb is as complex as that of chimpanzees but the human forelimb is less complex than in Pan. Importantly, in contrast to the analysis of morphological integration using morphometric approaches, network analyses do not support the prediction that forelimb and hindlimb are more dissimilar in species with functionally divergent limbs such as bipedal humans

Irish treebanking and parsing: a preliminary evaluation

Language resources are essential for linguistic research and the development of NLP applications. Low- density languages, such as Irish, therefore lack significant research in this area. This paper describes the early stages in the development of new language resources for Irish – namely the first Irish dependency treebank and the first Irish statistical dependency parser. We present the methodology behind building our new treebank and the steps we take to leverage upon the few existing resources. We discuss language specific choices made when defining our dependency labelling scheme, and describe interesting Irish language characteristics such as prepositional attachment, copula and clefting. We manually develop a small treebank of 300 sentences based on an existing POS-tagged corpus and report an inter-annotator agreement of 0.7902. We train MaltParser to achieve preliminary parsing results for Irish and describe a bootstrapping approach for further stages of development

Neonatal Diagnostics: Toward Dynamic Growth Charts of Neuromotor Control

© 2016 Torres, Smith, Mistry, Brincker and Whyatt. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).The current rise of neurodevelopmental disorders poses a critical need to detect risk early in order to rapidly intervene. One of the tools pediatricians use to track development is the standard growth chart. The growth charts are somewhat limited in predicting possible neurodevelopmental issues. They rely on linear models and assumptions of normality for physical growth data – obscuring key statistical information about possible neurodevelopmental risk in growth data that actually has accelerated, non-linear rates-of-change and variability encompassing skewed distributions. Here, we use new analytics to profile growth data from 36 newborn babies that were tracked longitudinally for 5 months. By switching to incremental (velocity-based) growth charts and combining these dynamic changes with underlying fluctuations in motor performance – as the transition from spontaneous random noise to a systematic signal – we demonstrate a method to detect very early stunting in the development of voluntary neuromotor control and to flag risk of neurodevelopmental derail.Peer reviewedFinal Published versio

Statistical parsing of morphologically rich languages (SPMRL): what, how and whither

The term Morphologically Rich Languages (MRLs) refers to languages in which significant information concerning syntactic units and relations is expressed at word-level. There is ample evidence that the application of readily available statistical parsing models to such languages is susceptible to serious performance degradation. The first workshop on statistical parsing of MRLs hosts a variety of contributions which show that despite language-specific idiosyncrasies, the problems associated with parsing MRLs cut across languages and parsing frameworks. In this paper we review the current state-of-affairs with respect to parsing MRLs and point out central challenges. We synthesize the contributions of researchers working on parsing Arabic, Basque, French, German, Hebrew, Hindi and Korean to point out shared solutions across languages. The overarching analysis suggests itself as a source of directions for future investigations