ALEC: Active learning with ensemble of classifiers for clinical diagnosis of coronary artery disease

Invasive angiography is the reference standard for coronary artery disease (CAD) diagnosis but is expensive and associated with certain risks. Machine learning (ML) using clinical and noninvasive imaging parameters can be used for CAD diagnosis to avoid the side effects and cost of angiography. However, ML methods require labeled samples for efficient training. The labeled data scarcity and high labeling costs can be mitigated by active learning. This is achieved through selective query of challenging samples for labeling. To the best of our knowledge, active learning has not been used for CAD diagnosis yet. An Active Learning with Ensemble of Classifiers (ALEC) method is proposed for CAD diagnosis, consisting of four classifiers. Three of these classifiers determine whether a patient’s three main coronary arteries are stenotic or not. The fourth classifier predicts whether the patient has CAD or not. ALEC is first trained using labeled samples. For each unlabeled sample, if the outputs of the classifiers are consistent, the sample along with its predicted label is added to the pool of labeled samples. Inconsistent samples are manually labeled by medical experts before being added to the pool. The training is performed once more using the samples labeled so far. The interleaved phases of labeling and training are repeated until all samples are labeled. Compared with 19 other active learning algorithms, ALEC combined with a support vector machine classifier attained superior performance with 97.01% accuracy. Our method is justified mathematically as well. We also comprehensively analyze the CAD dataset used in this paper. As part of dataset analysis, features pairwise correlation is computed. The top 15 features contributing to CAD and stenosis of the three main coronary arteries are determined. The relationship between stenosis of the main arteries is presented using conditional probabilities. The effect of considering the number of stenotic arteries on sample discrimination is investigated. The discrimination power over dataset samples is visualized, assuming each of the three main coronary arteries as a sample label and considering the two remaining arteries as sample features

Histopathological image analysis : a review

Over the past decade, dramatic increases in computational power and improvement in image analysis algorithms have allowed the development of powerful computer-assisted analytical approaches to radiological data. With the recent advent of whole slide digital scanners, tissue histopathology slides can now be digitized and stored in digital image form. Consequently, digitized tissue histopathology has now become amenable to the application of computerized image analysis and machine learning techniques. Analogous to the role of computer-assisted diagnosis (CAD) algorithms in medical imaging to complement the opinion of a radiologist, CAD algorithms have begun to be developed for disease detection, diagnosis, and prognosis prediction to complement the opinion of the pathologist. In this paper, we review the recent state of the art CAD technology for digitized histopathology. This paper also briefly describes the development and application of novel image analysis technology for a few specific histopathology related problems being pursued in the United States and Europe

Digital Image Access & Retrieval

The 33th Annual Clinic on Library Applications of Data Processing, held at the University of Illinois at Urbana-Champaign in March of 1996, addressed the theme of "Digital Image Access & Retrieval." The papers from this conference cover a wide range of topics concerning digital imaging technology for visual resource collections. Papers covered three general areas: (1) systems, planning, and implementation; (2) automatic and semi-automatic indexing; and (3) preservation with the bulk of the conference focusing on indexing and retrieval.published or submitted for publicatio

On discriminative semi-supervised incremental learning with a multi-view perspective for image concept modeling

This dissertation presents the development of a semi-supervised incremental learning framework with a multi-view perspective for image concept modeling. For reliable image concept characterization, having a large number of labeled images is crucial. However, the size of the training set is often limited due to the cost required for generating concept labels associated with objects in a large quantity of images. To address this issue, in this research, we propose to incrementally incorporate unlabeled samples into a learning process to enhance concept models originally learned with a small number of labeled samples. To tackle the sub-optimality problem of conventional techniques, the proposed incremental learning framework selects unlabeled samples based on an expected error reduction function that measures contributions of the unlabeled samples based on their ability to increase the modeling accuracy. To improve the convergence property of the proposed incremental learning framework, we further propose a multi-view learning approach that makes use of multiple features such as color, texture, etc., of images when including unlabeled samples. For robustness to mismatches between training and testing conditions, a discriminative learning algorithm, namely a kernelized maximal- figure-of-merit (kMFoM) learning approach is also developed. Combining individual techniques, we conduct a set of experiments on various image concept modeling problems, such as handwritten digit recognition, object recognition, and image spam detection to highlight the effectiveness of the proposed framework.PhDCommittee Chair: Lee, Chin-Hui; Committee Member: Clements, Mark; Committee Member: Lee, Hsien-Hsin; Committee Member: McClellan, James; Committee Member: Yuan, Min

Bridging semantic gap: learning and integrating semantics for content-based retrieval

Digital cameras have entered ordinary homes and produced^incredibly large number of photos. As a typical example of broad image domain, unconstrained consumer photos vary significantly. Unlike professional or domain-specific images, the objects in the photos are ill-posed, occluded, and cluttered with poor lighting, focus, and exposure. Content-based image retrieval research has yet to bridge the semantic gap between computable low-level information and high-level user interpretation. In this thesis, we address the issue of semantic gap with a structured learning framework to allow modular extraction of visual semantics. Semantic image regions (e.g. face, building, sky etc) are learned statistically, detected directly from image without segmentation, reconciled across multiple scales, and aggregated spatially to form compact semantic index. To circumvent the ambiguity and subjectivity in a query, a new query method that allows spatial arrangement of visual semantics is proposed. A query is represented as a disjunctive normal form of visual query terms and processed using fuzzy set operators. A drawback of supervised learning is the manual labeling of regions as training samples. In this thesis, a new learning framework to discover local semantic patterns and to generate their samples for training with minimal human intervention has been developed. The discovered patterns can be visualized and used in semantic indexing. In addition, three new class-based indexing schemes are explored. The winnertake- all scheme supports class-based image retrieval. The class relative scheme and the local classification scheme compute inter-class memberships and local class patterns as indexes for similarity matching respectively. A Bayesian formulation is proposed to unify local and global indexes in image comparison and ranking that resulted in superior image retrieval performance over those of single indexes. Query-by-example experiments on 2400 consumer photos with 16 semantic queries show that the proposed approaches have significantly better (18% to 55%) average precisions than a high-dimension feature fusion approach. The thesis has paved two promising research directions, namely the semantics design approach and the semantics discovery approach. They form elegant dual frameworks that exploits pattern classifiers in learning and integrating local and global image semantics

When in doubt ask the crowd : leveraging collective intelligence for improving event detection and machine learning

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