Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Distributed Model Predictive Consensus via the Alternating Direction Method of Multipliers

We propose a distributed optimization method for solving a distributed model predictive consensus problem. The goal is to design a distributed controller for a network of dynamical systems to optimize a coupled objective function while respecting state and input constraints. The distributed optimization method is an augmented Lagrangian method called the Alternating Direction Method of Multipliers (ADMM), which was introduced in the 1970s but has seen a recent resurgence in the context of dramatic increases in computing power and the development of widely available distributed computing platforms. The method is applied to position and velocity consensus in a network of double integrators. We find that a few tens of ADMM iterations yield closed-loop performance near what is achieved by solving the optimization problem centrally. Furthermore, the use of recent code generation techniques for solving local subproblems yields fast overall computation times.Comment: 7 pages, 5 figures, 50th Allerton Conference on Communication, Control, and Computing, Monticello, IL, USA, 201

A survey on fractional order control techniques for unmanned aerial and ground vehicles

In recent years, numerous applications of science and engineering for modeling and control of unmanned aerial vehicles (UAVs) and unmanned ground vehicles (UGVs) systems based on fractional calculus have been realized. The extra fractional order derivative terms allow to optimizing the performance of the systems. The review presented in this paper focuses on the control problems of the UAVs and UGVs that have been addressed by the fractional order techniques over the last decade