Personalized medicine support system : resolving conflict in allocation to risk groups and predicting patient molecular response to targeted therapy

Treatment management in cancer patients is largely based on the use of a standardized set of predictive and prognostic factors. The former are used to evaluate specific clinical interventions, and they can be useful for selecting treatments because they directly predict the response to a treatment. The latter are used to evaluate a patient’s overall outcomes, and can be used to identify the risks or recurrence of a disease. Current intelligent systems can be a solution for transferring advancements in molecular biology into practice, especially for predicting the molecular response to molecular targeted therapy and the prognosis of risk groups in cancer medicine. This framework primarily focuses on the importance of integrating domain knowledge in predictive and prognostic models for personalized treatment. Our personalized medicine support system provides the needed support in complex decisions and can be incorporated into a treatment guide for selecting molecular targeted therapies.Haneen Banjar, David Adelson, Fred Brown, and Tamara Leclerc

Some Remarks about the Complexity of Epidemics Management

Recent outbreaks of Ebola, H1N1 and other infectious diseases have shown that the assumptions underlying the established theory of epidemics management are too idealistic. For an improvement of procedures and organizations involved in fighting epidemics, extended models of epidemics management are required. The necessary extensions consist in a representation of the management loop and the potential frictions influencing the loop. The effects of the non-deterministic frictions can be taken into account by including the measures of robustness and risk in the assessment of management options. Thus, besides of the increased structural complexity resulting from the model extensions, the computational complexity of the task of epidemics management - interpreted as an optimization problem - is increased as well. This is a serious obstacle for analyzing the model and may require an additional pre-processing enabling a simplification of the analysis process. The paper closes with an outlook discussing some forthcoming problems

Portfolio Selection: Assessment of a Framework

Decision-making often involves selecting a portfolio of alternatives, rather than a single option. For example, in assembling an IS project team, rather than picking one best” employee, multiple employees are selected based on various skills to fill different positions. The value of the employees depending not only on their individual competency skills, but also on how well they work as a team. The team synergy is important, and the value of the portfolio (i.e. IS project team in this case) is different from the sum of the values of the individual team members. Though many studies have been published on portfolio selection in diverse contexts, most of these studies tend to focus on specific problem environments and cannot easily be generalized. This paper assesses and enhances a previously published, general framework for portfolio decisions with respect to its usefulness in classifying and understanding decision problems

A Hybrid Approach to Identifying the Most Predictive and Discriminant Features in Supervised Classification Problems

International audienceIn this paper, we are interested in the predictive and discriminant nature of features in supervised classification problems. We discuss the notions of prediction and discrimination and propose a hybrid approach combining supervised classifiers, model explanation, multicriteria decision making and pattern mining for identifying the most predictive and discriminant features in a dataset. The explanation of models learned by supervised classifiers produces rankings of features according to various performance measures. Based on that, multicriteria decision making and pattern mining methods are used to, respectively, select the most important features and interpret their role in terms of prediction and discrimination. Finally, we present and discuss two experiments on public datasets illustrating the potential of the approach

Applying the Analytic Hierarchy Process in healthcare research: A systematic literature review and evaluation of reporting

Background: The Analytic Hierarchy Process (AHP), developed by Saaty in the late 1970s, is one of the methods for multi-criteria decision making. The AHP disaggregates a complex decision problem into different hierarchical levels. The weight for each criterion and alternative are judged in pairwise comparisons and priorities are calculated by the Eigenvector method. The slowly increasing application of the AHP was the motivation for this study to explore the current state of its methodology in the healthcare context. Methods: A systematic literature review was conducted by searching the Pubmed and Web of Science databases for articles with the following keywords in their titles or abstracts: "Analytic Hierarchy Process," "Analytical Hierarchy Process," "multi-criteria decision analysis," "multiple criteria decision," "stated preference," and "pairwise comparison." In addition, we developed reporting criteria to indicate whether the authors reported important aspects and evaluated the resulting studies' reporting. Results: The systematic review resulted in 121 articles. The number of studies applying AHP has increased since 2005. Most studies were from Asia (almost 30 %), followed by the US (25.6 %). On average, the studies used 19.64 criteria throughout their hierarchical levels. Furthermore, we restricted a detailed analysis to those articles published within the last 5 years (n = 69). The mean of participants in these studies were 109, whereas we identified major differences in how the surveys were conducted. The evaluation of reporting showed that the mean of reported elements was about 6.75 out of 10. Thus, 12 out of 69 studies reported less than half of the criteria. Conclusion: The AHP has been applied inconsistently in healthcare research. A minority of studies described all the relevant aspects. Thus, the statements in this review may be biased, as they are restricted to the information available in the papers. Hence, further research is required to discover who should be interviewed and how, how inconsistent answers should be dealt with, and how the outcome and stability of the results should be presented. In addition, we need new insights to determine which target group can best handle the challenges of the AHP.CHER

Advances in Methodology and Applications of Decision Support Systems

These Proceedings are composed of a selection of papers of the Workshop on Advances in Methodology and Applications of Decision Support Systems, organized by the System and Decision Sciences (SDS) Program of IIASA and the Japan Institute of Systems Research (JISR). The workshop was held at IIASA on August 20-22, 1990. The Methodology of Decision Analysis (MDA) Project of the SDS Program focuses on a system-analytical approach to decision support and is devoted to developing methodology, software and applications of decision support systems concentrated primarily around interactive systems for data analysis, interpretation and multiobjective decisionmaking, including uncertainty analysis and group decision making situations in both their cooperative and noncooperative aspects. The objectives of the research on decision support systems (DSS) performed in cooperation with the MDA Project are to: compare various approaches to decision support systems; advance theory and methodology of decision support; convert existing theories and methodologies into usable (simple to use, user-friendly and robust) tools that could easily be used in solving real-life problems. A principal characteristic of decision support systems is that they must be tuned to specific decision situations, to complex real-life characteristics of every application. Even if the theory and methodology of decision support is quite advanced, every application might provide impulses for further theoretical and methodological advances. Therefore the principle underlying this project is that theoretical and methodological research should be strongly connected to the implementation and applications of its results to sufficiently complicated, real-life examples. This approach results in obtaining really applicable working tools for decision support. The papers for this Proceedings have been selected according to the above summarized framework of the research activities. Therefore, the papers deal both with theoretical and methodological problems and with real-life applications