Heterogeneous biomedical database integration using a hybrid strategy: a p53 cancer research database.

Complex problems in life science research give rise to multidisciplinary collaboration, and hence, to the need for heterogeneous database integration. The tumor suppressor p53 is mutated in close to 50% of human cancers, and a small drug-like molecule with the ability to restore native function to cancerous p53 mutants is a long-held medical goal of cancer treatment. The Cancer Research DataBase (CRDB) was designed in support of a project to find such small molecules. As a cancer informatics project, the CRDB involved small molecule data, computational docking results, functional assays, and protein structure data. As an example of the hybrid strategy for data integration, it combined the mediation and data warehousing approaches. This paper uses the CRDB to illustrate the hybrid strategy as a viable approach to heterogeneous data integration in biomedicine, and provides a design method for those considering similar systems. More efficient data sharing implies increased productivity, and, hopefully, improved chances of success in cancer research. (Code and database schemas are freely downloadable, http://www.igb.uci.edu/research/research.html.)

Schema architecture and their relationships to transaction processing in distributed database systems

We discuss the different types of schema architectures which could be supported by distributed database systems, making a clear distinction between logical, physical, and federated distribution. We elaborate on the additional mapping information required in architecture based on logical distribution in order to support retrieval as well as update operations. We illustrate the problems in schema integration and data integration in multidatabase systems and discuss their impact on query processing. Finally, we discuss different issues relevant to the cooperation (or noncooperation) of local database systems in a heterogeneous multidatabase system and their relationship to the schema architecture and transaction processing

Intersection schemas as a dataspace integration technique

This paper introduces the concept of Intersection Schemas in the field of heterogeneous data integration and dataspaces. We introduce a technique for incrementally integrating heterogeneous data sources by specifying semantic overlaps between sets of extensional schemas using bidirectional schema transformations, and automatically combining them into a global schema at each iteration of the integration process. We propose an incremental data integration methodology that uses this technique and that aims to reduce the amount of up-front effort required. Such approaches to data integration are often described as pay-as-you-go. A demonstrator of our technique is described, which utilizes a new graphical user tool implemented using the AutoMed heterogeneous data integration system. A case study is also described, and our technique and integration methodology are compared with a classical data integration strategy

XML Matchers: approaches and challenges

Schema Matching, i.e. the process of discovering semantic correspondences between concepts adopted in different data source schemas, has been a key topic in Database and Artificial Intelligence research areas for many years. In the past, it was largely investigated especially for classical database models (e.g., E/R schemas, relational databases, etc.). However, in the latest years, the widespread adoption of XML in the most disparate application fields pushed a growing number of researchers to design XML-specific Schema Matching approaches, called XML Matchers, aiming at finding semantic matchings between concepts defined in DTDs and XSDs. XML Matchers do not just take well-known techniques originally designed for other data models and apply them on DTDs/XSDs, but they exploit specific XML features (e.g., the hierarchical structure of a DTD/XSD) to improve the performance of the Schema Matching process. The design of XML Matchers is currently a well-established research area. The main goal of this paper is to provide a detailed description and classification of XML Matchers. We first describe to what extent the specificities of DTDs/XSDs impact on the Schema Matching task. Then we introduce a template, called XML Matcher Template, that describes the main components of an XML Matcher, their role and behavior. We illustrate how each of these components has been implemented in some popular XML Matchers. We consider our XML Matcher Template as the baseline for objectively comparing approaches that, at first glance, might appear as unrelated. The introduction of this template can be useful in the design of future XML Matchers. Finally, we analyze commercial tools implementing XML Matchers and introduce two challenging issues strictly related to this topic, namely XML source clustering and uncertainty management in XML Matchers.Comment: 34 pages, 8 tables, 7 figure