E-infrastructures fostering multi-centre collaborative research into the intensive care management of patients with brain injury

Clinical research is becoming ever more collaborative with multi-centre trials now a common practice. With this in mind, never has it been more important to have secure access to data and, in so doing, tackle the challenges of inter-organisational data access and usage. This is especially the case for research conducted within the brain injury domain due to the complicated multi-trauma nature of the disease with its associated complex collation of time-series data of varying resolution and quality. It is now widely accepted that advances in treatment within this group of patients will only be delivered if the technical infrastructures underpinning the collection and validation of multi-centre research data for clinical trials is improved. In recognition of this need, IT-based multi-centre e-Infrastructures such as the Brain Monitoring with Information Technology group (BrainIT - www.brainit.org) and Cooperative Study on Brain Injury Depolarisations (COSBID - www.cosbid.de) have been formed. A serious impediment to the effective implementation of these networks is access to the know-how and experience needed to install, deploy and manage security-oriented middleware systems that provide secure access to distributed hospital based datasets and especially the linkage of these data sets across sites. The recently funded EU framework VII ICT project Advanced Arterial Hypotension Adverse Event prediction through a Novel Bayesian Neural Network (AVERT-IT) is focused upon tackling these challenges. This chapter describes the problems inherent to data collection within the brain injury medical domain, the current IT-based solutions designed to address these problems and how they perform in practice. We outline how the authors have collaborated towards developing Grid solutions to address the major technical issues. Towards this end we describe a prototype solution which ultimately formed the basis for the AVERT-IT project. We describe the design of the underlying Grid infrastructure for AVERT-IT and how it will be used to produce novel approaches to data collection, data validation and clinical trial design is also presented

Security for Grid Services

Grid computing is concerned with the sharing and coordinated use of diverse resources in distributed "virtual organizations." The dynamic and multi-institutional nature of these environments introduces challenging security issues that demand new technical approaches. In particular, one must deal with diverse local mechanisms, support dynamic creation of services, and enable dynamic creation of trust domains. We describe how these issues are addressed in two generations of the Globus Toolkit. First, we review the Globus Toolkit version 2 (GT2) approach; then, we describe new approaches developed to support the Globus Toolkit version 3 (GT3) implementation of the Open Grid Services Architecture, an initiative that is recasting Grid concepts within a service oriented framework based on Web services. GT3's security implementation uses Web services security mechanisms for credential exchange and other purposes, and introduces a tight least-privilege model that avoids the need for any privileged network service.Comment: 10 pages; 4 figure

Integrating security solutions to support nanoCMOS electronics research

The UK Engineering and Physical Sciences Research Council (EPSRC) funded Meeting the Design Challenges of nanoCMOS Electronics (nanoCMOS) is developing a research infrastructure for collaborative electronics research across multiple institutions in the UK with especially strong industrial and commercial involvement. Unlike other domains, the electronics industry is driven by the necessity of protecting the intellectual property of the data, designs and software associated with next generation electronics devices and therefore requires fine-grained security. Similarly, the project also demands seamless access to large scale high performance compute resources for atomic scale device simulations and the capability to manage the hundreds of thousands of files and the metadata associated with these simulations. Within this context, the project has explored a wide range of authentication and authorization infrastructures facilitating compute resource access and providing fine-grained security over numerous distributed file stores and files. We conclude that no single security solution meets the needs of the project. This paper describes the experiences of applying X.509-based certificates and public key infrastructures, VOMS, PERMIS, Kerberos and the Internet2 Shibboleth technologies for nanoCMOS security. We outline how we are integrating these solutions to provide a complete end-end security framework meeting the demands of the nanoCMOS electronics domain

Comparison of advanced authorisation infrastructures for grid computing

The widespread use of grid technology and distributed compute power, with all its inherent benefits, will only be established if the use of that technology can be guaranteed efficient and secure. The predominant method for currently enforcing security is through the use of public key infrastructures (PKI) to support authentication and the use of access control lists (ACL) to support authorisation. These systems alone do not provide enough fine-grained control over the restriction of user rights, necessary in a dynamic grid environment. This paper compares the implementation and experiences of using the current standard for grid authorisation with Globus - the grid security infrastructure (GSI) - with the role-based access control (RBAC) authorisation infrastructure PERMIS. The suitability of these security infrastructures for integration with regard to existing grid technology is presented based upon experiences within the JISC-funded DyVOSE project

User oriented access to secure biomedical resources through the grid

The life science domain is typified by heterogeneous data sets that are evolving at an exponential rate. Numerous post-genomic databases and areas of post-genomic life science research have been established and are being actively explored. Whilst many of these databases are public and freely accessible, it is often the case that researchers have data that is not so freely available and access to this data needs to be strictly controlled when distributed collaborative research is undertaken. Grid technologies provide one mechanism by which access to and integration of federated data sets is possible. Combining such data access and integration technologies with fine grained security infrastructures facilitates the establishment of virtual organisations (VO). However experience has shown that the general research (non-Grid) community are not comfortable with the Grid and its associated security models based upon public key infrastructures (PKIs). The Internet2 Shibboleth technology helps to overcome this through users only having to log in to their home site to gain access to resources across a VO – or in Shibboleth terminology a federation. In this paper we outline how we have applied the combination of Grid technologies, advanced security infrastructures and the Internet2 Shibboleth technology in several biomedical projects to provide a user-oriented model for secure access to and usage of Grid resources. We believe that this model may well become the de facto mechanism for undertaking e-Research on the Grid across numerous domains including the life sciences

Grid Infrastructure for Domain Decomposition Methods in Computational ElectroMagnetics

The accurate and efficient solution of Maxwell's equation is the problem addressed by the scientific discipline called Computational ElectroMagnetics (CEM). Many macroscopic phenomena in a great number of fields are governed by this set of differential equations: electronic, geophysics, medical and biomedical technologies, virtual EM prototyping, besides the traditional antenna and propagation applications. Therefore, many efforts are focussed on the development of new and more efficient approach to solve Maxwell's equation. The interest in CEM applications is growing on. Several problems, hard to figure out few years ago, can now be easily addressed thanks to the reliability and flexibility of new technologies, together with the increased computational power. This technology evolution opens the possibility to address large and complex tasks. Many of these applications aim to simulate the electromagnetic behavior, for example in terms of input impedance and radiation pattern in antenna problems, or Radar Cross Section for scattering applications. Instead, problems, which solution requires high accuracy, need to implement full wave analysis techniques, e.g., virtual prototyping context, where the objective is to obtain reliable simulations in order to minimize measurement number, and as consequence their cost. Besides, other tasks require the analysis of complete structures (that include an high number of details) by directly simulating a CAD Model. This approach allows to relieve researcher of the burden of removing useless details, while maintaining the original complexity and taking into account all details. Unfortunately, this reduction implies: (a) high computational effort, due to the increased number of degrees of freedom, and (b) worsening of spectral properties of the linear system during complex analysis. The above considerations underline the needs to identify appropriate information technologies that ease solution achievement and fasten required elaborations. The authors analysis and expertise infer that Grid Computing techniques can be very useful to these purposes. Grids appear mainly in high performance computing environments. In this context, hundreds of off-the-shelf nodes are linked together and work in parallel to solve problems, that, previously, could be addressed sequentially or by using supercomputers. Grid Computing is a technique developed to elaborate enormous amounts of data and enables large-scale resource sharing to solve problem by exploiting distributed scenarios. The main advantage of Grid is due to parallel computing, indeed if a problem can be split in smaller tasks, that can be executed independently, its solution calculation fasten up considerably. To exploit this advantage, it is necessary to identify a technique able to split original electromagnetic task into a set of smaller subproblems. The Domain Decomposition (DD) technique, based on the block generation algorithm introduced in Matekovits et al. (2007) and Francavilla et al. (2011), perfectly addresses our requirements (see Section 3.4 for details). In this chapter, a Grid Computing infrastructure is presented. This architecture allows parallel block execution by distributing tasks to nodes that belong to the Grid. The set of nodes is composed by physical machines and virtualized ones. This feature enables great flexibility and increase available computational power. Furthermore, the presence of virtual nodes allows a full and efficient Grid usage, indeed the presented architecture can be used by different users that run different applications