4,335 research outputs found
Design and evaluation of a genomics variant analysis pipeline using GATK Spark tools
Scalable and efficient processing of genome sequence data, i.e. for variant
discovery, is key to the mainstream adoption of High Throughput technology for
disease prevention and for clinical use. Achieving scalability, however,
requires a significant effort to enable the parallel execution of the analysis
tools that make up the pipelines. This is facilitated by the new Spark versions
of the well-known GATK toolkit, which offer a black-box approach by
transparently exploiting the underlying Map Reduce architecture. In this paper
we report on our experience implementing a standard variant discovery pipeline
using GATK 4.0 with Docker-based deployment over a cluster. We provide a
preliminary performance analysis, comparing the processing times and cost to
those of the new Microsoft Genomics Services
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Computational Strategies for Scalable Genomics Analysis.
The revolution in next-generation DNA sequencing technologies is leading to explosive data growth in genomics, posing a significant challenge to the computing infrastructure and software algorithms for genomics analysis. Various big data technologies have been explored to scale up/out current bioinformatics solutions to mine the big genomics data. In this review, we survey some of these exciting developments in the applications of parallel distributed computing and special hardware to genomics. We comment on the pros and cons of each strategy in the context of ease of development, robustness, scalability, and efficiency. Although this review is written for an audience from the genomics and bioinformatics fields, it may also be informative for the audience of computer science with interests in genomics applications
Performance-oriented Cloud Provisioning: Taxonomy and Survey
Cloud computing is being viewed as the technology of today and the future.
Through this paradigm, the customers gain access to shared computing resources
located in remote data centers that are hosted by cloud providers (CP). This
technology allows for provisioning of various resources such as virtual
machines (VM), physical machines, processors, memory, network, storage and
software as per the needs of customers. Application providers (AP), who are
customers of the CP, deploy applications on the cloud infrastructure and then
these applications are used by the end-users. To meet the fluctuating
application workload demands, dynamic provisioning is essential and this
article provides a detailed literature survey of dynamic provisioning within
cloud systems with focus on application performance. The well-known types of
provisioning and the associated problems are clearly and pictorially explained
and the provisioning terminology is clarified. A very detailed and general
cloud provisioning classification is presented, which views provisioning from
different perspectives, aiding in understanding the process inside-out. Cloud
dynamic provisioning is explained by considering resources, stakeholders,
techniques, technologies, algorithms, problems, goals and more.Comment: 14 pages, 3 figures, 3 table
Value-Based Allocation of Docker Containers
Recently, an increasing number of public cloud vendors added Containers as a Service (CaaS) to their service portfolio. This is an adequate answer to the growing popularity of Docker, a software technology allowing Linux containers to run independently on a host in an isolated environment. As any software can be deployed in a container, the nature of containers differs and thus assorted allocation and orchestration approaches are needed for their effective execution. In this paper, we focus on containers whose execution value for end users varies over time. A baseline and two dynamic allocation algorithms are proposed and compared with the default Docker scheduling algorithm. Experiments show that the proposed approach can increase the total value obtained from a workload up to three times depending on the workload heaviness. It is also demonstrated that the algorithms scale well with the growing number of nodes in a cloud
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