68,788 research outputs found
Modeling Binary Time Series Using Gaussian Processes with Application to Predicting Sleep States
Motivated by the problem of predicting sleep states, we develop a mixed
effects model for binary time series with a stochastic component represented by
a Gaussian process. The fixed component captures the effects of covariates on
the binary-valued response. The Gaussian process captures the residual
variations in the binary response that are not explained by covariates and past
realizations. We develop a frequentist modeling framework that provides
efficient inference and more accurate predictions. Results demonstrate the
advantages of improved prediction rates over existing approaches such as
logistic regression, generalized additive mixed model, models for ordinal data,
gradient boosting, decision tree and random forest. Using our proposed model,
we show that previous sleep state and heart rates are significant predictors
for future sleep states. Simulation studies also show that our proposed method
is promising and robust. To handle computational complexity, we utilize Laplace
approximation, golden section search and successive parabolic interpolation.
With this paper, we also submit an R-package (HIBITS) that implements the
proposed procedure.Comment: Journal of Classification (2018
Deep Convolutional Neural Networks for Interpretable Analysis of EEG Sleep Stage Scoring
Sleep studies are important for diagnosing sleep disorders such as insomnia,
narcolepsy or sleep apnea. They rely on manual scoring of sleep stages from raw
polisomnography signals, which is a tedious visual task requiring the workload
of highly trained professionals. Consequently, research efforts to purse for an
automatic stage scoring based on machine learning techniques have been carried
out over the last years. In this work, we resort to multitaper spectral
analysis to create visually interpretable images of sleep patterns from EEG
signals as inputs to a deep convolutional network trained to solve visual
recognition tasks. As a working example of transfer learning, a system able to
accurately classify sleep stages in new unseen patients is presented.
Evaluations in a widely-used publicly available dataset favourably compare to
state-of-the-art results, while providing a framework for visual interpretation
of outcomes.Comment: 8 pages, 1 figure, 2 tables, IEEE 2017 International Workshop on
Machine Learning for Signal Processin
Robust, automated sleep scoring by a compact neural network with distributional shift correction.
Studying the biology of sleep requires the accurate assessment of the state of experimental subjects, and manual analysis of relevant data is a major bottleneck. Recently, deep learning applied to electroencephalogram and electromyogram data has shown great promise as a sleep scoring method, approaching the limits of inter-rater reliability. As with any machine learning algorithm, the inputs to a sleep scoring classifier are typically standardized in order to remove distributional shift caused by variability in the signal collection process. However, in scientific data, experimental manipulations introduce variability that should not be removed. For example, in sleep scoring, the fraction of time spent in each arousal state can vary between control and experimental subjects. We introduce a standardization method, mixture z-scoring, that preserves this crucial form of distributional shift. Using both a simulated experiment and mouse in vivo data, we demonstrate that a common standardization method used by state-of-the-art sleep scoring algorithms introduces systematic bias, but that mixture z-scoring does not. We present a free, open-source user interface that uses a compact neural network and mixture z-scoring to allow for rapid sleep scoring with accuracy that compares well to contemporary methods. This work provides a set of computational tools for the robust automation of sleep scoring
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