Network analysis of circular permutations in multidomain proteins reveals functional linkages for uncharacterized proteins.

Various studies have implicated different multidomain proteins in cancer. However, there has been little or no detailed study on the role of circular multidomain proteins in the general problem of cancer or on specific cancer types. This work represents an initial attempt at investigating the potential for predicting linkages between known cancer-associated proteins with uncharacterized or hypothetical multidomain proteins, based primarily on circular permutation (CP) relationships. First, we propose an efficient algorithm for rapid identification of both exact and approximate CPs in multidomain proteins. Using the circular relations identified, we construct networks between multidomain proteins, based on which we perform functional annotation of multidomain proteins. We then extend the method to construct subnetworks for selected cancer subtypes, and performed prediction of potential link-ages between uncharacterized multidomain proteins and the selected cancer types. We include practical results showing the performance of the proposed methods

Improved Periodicity Mining in Time Series Databases

Time series data represents information about real world phenomena and periodicity mining explores the interesting periodic behavior that is inherent in the data. Periodicity mining has numerous applications such as in weather forecasting, stock market prediction and analysis, pattern recognition, etc. Recently, the suffix tree, a powerful data structure that efficiently solves many strings related problems has been used to gather information about repeated substrings in the text and then perform periodicity mining. However, periodicity mining deals with large amounts of data which makes it difficult to perform mining in main memory due to the space constraints of the suffix tree. Thus, we first propose the use of the Compressed Suffix Tree (CST) for space efficient periodicity mining in very large datasets. Given the time-space trade-off that comes with any practical usage of the CST, we provide a comprehensive empirical analysis on the practical usage of CSTs and traditional suffix trees for periodicity mining.;Noise is an inherent part of practical time series data, and it is important to mine periods in spite of the noise. This leads to the problem of approximate periodicity mining. Existing algorithms have dealt with the noise introduced between the occurrences of the periodic pattern, but not the noise introduced in the structure of the pattern itself. We present a taxonomy for approximate periodicity and then propose an algorithm that performs periodicity mining in the presence of noise introduced simultaneously in both the structure of the pattern and between the periodic occurrences of the pattern

Suffix Structures and Circular Pattern Problems

The suffix tree is a data structure used to represent all the suffixes in a string. However, a major problem with the suffix tree is its practical space requirement. In this dissertation, we propose an efficient data structure -- the virtual suffix tree (VST) -- which requires less space than other recently proposed data structures for suffix trees and suffix arrays. On average, the space requirement (including that for suffix arrays and suffix links) is 13.8n bytes for the regular VST, and 12.05n bytes in its compact form, where n is the length of the sequence.;Markov models are very popular for modeling complex sequences. In this dissertation, we present the probabilistic suffix array (PSA), a space-efficient alternative to the probabilistic suffix tree (PST) used to represent Markov models. The PSA provides all the capabilities of the PST, such as learning and prediction, and maintains the same linear time construction (linearity with respect to sequence length). The PSA, however, has a significantly smaller memory requirement than the PST, for both the construction stage, and at the time of usage.;Using the proposed suffix data structures, we study the circular pattern matching (CPM) problem. We provide a linear time, linear space algorithm to solve the exact circular pattern matching problem. We then present four algorithms to address the approximate circular pattern matching (ACPM) problem. Our bidirectional ACPM algorithm provides the best time complexity when compared with other algorithms proposed in the literature. Further, we define the circular pattern discovery (CPD) problem and present algorithms to solve this problem. Using the proposed circular pattern matching algorithms, we perform experiments on computational analysis and function prediction for multidomain proteins