60,291 research outputs found
Modeling specific action potentials in the human atria based on a minimal reaction-diffusion model
We present an effective method to model empirical action potentials of
specific patients in the human atria based on the minimal model of
Bueno-Orovio, Cherry and Fenton adapted to atrial electrophysiology. In this
model, three ionic are currents introduced, where each of it is governed by a
characteristic time scale. By applying a nonlinear optimization procedure, a
best combination of the respective time scales is determined, which allows one
to reproduce specific action potentials with a given amplitude, width and
shape. Possible applications for supporting clinical diagnosis are pointed out.Comment: 16 pages, 8 figure
Similarities between action potentials and acoustic pulses in a van der Waals fluid
An action potential is typically described as a purely electrical change that
propagates along the membrane of excitable cells. However, recent experiments
have demonstrated that non-linear acoustic pulses that propagate along lipid
interfaces and traverse the melting transition, share many similar properties
with action potentials. Despite the striking experimental similarities, a
comprehensive theoretical study of acoustic pulses in lipid systems is still
lacking. Here we demonstrate that an idealized description of an interface near
phase transition captures many properties of acoustic pulses in lipid
monolayers, as well as action potentials in living cells. The possibility that
action potentials may better be described as acoustic pulses in soft interfaces
near phase transition is illustrated by the following similar properties:
correspondence of time and velocity scales, qualitative pulse shape, sigmoidal
response to stimulation amplitude (an `all-or-none' behavior), appearance in
multiple observables (particularly, an adiabatic change of temperature),
excitation by many types of stimulations, as well as annihilation upon
collision. An implication of this work is that crucial functional information
of the cell may be overlooked by focusing only on electrical measurements.Comment: 8 pages, 5 figure
Temporal Precision of Spike Trains in Extrastriate Cortex of the Behaving Macaque Monkey
How reliably do action potentials in cortical neurons encode information about a visual stimulus? Most physiological studies do not weigh the occurrences of particular action potentials as significant but treat them only as reflections of average neuronal excitation. We report that single neurons recorded in a previous study by Newsome et al. (1989; see also Britten et al. 1992) from cortical area MT in the behaving monkey respond to dynamic and unpredictable motion stimuli with a markedly reproducible temporal modulation that is precise to a few milliseconds. This temporal modulation is stimulus dependent, being present for highly dynamic random motion but absent when the stimulus translates rigidly
Investigation of otolith responses using ground based vestibular research facility
The general goal was to examine tilt sensitivity of horizontal semicircular canal afferents. Computer programs were tested which controlled the short axis centrifuge at the Vestibular Research Facility, acquired action potentials and produced data reduction analyses including histograms and gain and phase calculations. A pre-amplifier was also developed for the acquisition of action potentials. The data were gathered that can be used to contribute toward the understanding of the tilt sensitivity of semicircular canal afferents in the unanesthetized gerbil preparation
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