Accuracy of drug advertisements in medical journals under new law regulating the marketing of pharmaceutical products in Switzerland

<p>Abstract</p> <p>Background</p> <p>New legal regulations for the marketing of pharmaceutical products were introduced in 2002 in Switzerland. We investigated whether claims in drug advertisements citing published scientific studies were justified by these studies after the introduction of these new regulations.</p> <p>Methods</p> <p>In this cross-sectional study, two independent reviewers screened all issues of six major Swiss medical journals published in the year 2005 to identify all drug advertisements for analgesic, gastrointestinal and psychopharmacologic drugs and evaluated all drug advertisements referring to at least one publication. The pharmaceutical claim was rated as being supported, being based on a potentially biased study or not to be supported by the cited study according to pre-specified criteria. We also explored factors likely to be associated with supported advertisement claims.</p> <p>Results</p> <p>Of 2068 advertisements 577 (28%) promoted analgesic, psychopharmacologic or gastrointestinal drugs. Among them were 323 (56%) advertisements citing at least one reference. After excluding multiple publications of the same drug advertisement and advertisements with non-informative references, there remained 29 unique advertisements with at least one reference to a scientific study. These 29 advertisements contained 78 distinct pairs of claims of analgesic, gastrointestinal and psychopharmacologic drugs and referenced studies. Thirty-seven (47%) claims were supported, 16 (21%) claims were not supported by the corresponding reference, and 25 (32%) claims were based on potentially biased evidence, with no relevant differences between drug groups. Studies with conflict of interest and studies stating industry funding were more likely to support the corresponding claim (RR 1.52, 95% CI 1.07–2.17 and RR 1.50, 95% CI 0.98–2.28) than studies without identified conflict of interest and studies without information on type of funding.</p> <p>Conclusion</p> <p>Following the introduction of new regulations for drug advertisement in Switzerland, 53% of all assessed pharmaceutical claims published in major medical journals are not supported by the cited referenced studies or based on potentially biased study information. In light of the discrepancy between the new legislation and the endorsement of these regulations, physicians should not trust drug advertisement claims even when they seem to refer to scientific studies.</p

Corporate social responsibility practices of pharmaceutical companies in China: a scale development & empirical study

JEL Classification: M14 - Corporate Culture; Social Responsibility; I11 - Analysis of Health Care MarketsCorporate Social Responsibility (CSR) has been a hot topic in literature ever since a couple of decades ago, and it roughly refers to the positive influence that a company’s operations have on its stakeholders. Amongst various industries, the pharmaceutical sector is one of the most debated in that these companies produce disease-curing and even life-saving products in a for-profit manner, thereby involving many CSR-related issues. Now China’s pharmaceutical industry has the second largest output in the world, but various problems have also emerged and led to negative consequences, many of which were caused by failure to abide by CSR norms. In order to assess the CSR practices of pharmaceutical companies in China, a reliable and credible measurement instrument has to be available. However, currently there is still no universally accepted definition of CSR, and existing theoretical models fail to fit either characteristics of the pharmaceutical industry or China’s cultural context. As a result, a new model has to be built that takes both factors into account. The study has two main purposes: one is to design an original and valid scale for measuring the CSR practices of pharmaceutical companies in China, and the other is to use this tool to evaluate their actual CSR performance. Based on a standard scale development process (in-depth interviews, open-ended questionnaire, discussions with experts, reliability and validity evaluation with exploratory and confirmatory factor analyses), finally an eight-dimensional and 36-item measurement tool was validated. The eight initial dimensions (Shareholders, Managers, and Employees; Creditors & Suppliers, Patients & Doctors; Government, Environment, and Local Community) were then transformed into three second-order dimensions: CSR for Internal Parties, CSR for External Partners, and CSR for Public Entities. This conceptual model was later applied to reveal the circumstances within China’s pharmaceutical industry. Results show that CSR practices in the pharmaceutical industry in China coexist at very different levels: foreign-owned companies and joint ventures generally outperformed their state-owned and privately owned counterparts, and larger companies also had better CSR citizenship than smaller ones.A Responsabilidade Social das Empresas (RSE) tem sido um tópico recorrente na literatura nas duas últimas décadas e, de forma muito resumida, refere-se à influência positiva que a atividade empresarial pode ter nos seus diversos stakeholders. De entre os múltiplos setores de atividade, a indústria farmacêutica é uma das mais discutidas por produzir medicamentos que curam doenças e salvam vidas mas de forma lucrativa, e por isso, envolvendo muitos problemas relacionados com a RSE. Atualmente, a indústria farmacêutica na China é segunda em termos de produção mundial, mas apresenta problemas variados com consequências negativas, muitas delas resultantes do não cumprimento das normas de resonsabilidade social. Para que se possam avaliar as práticas de RSE na China, é necessário um instrumento de medida fiável e válido. No entanto, até ao momento não existe uma escala de medida da RSE universalmente aceite e os atuais modelos teóricos não incorporam as características da indústria farmacêutica e o contexto cultural específico da China. Daí a necessidade de desenvolvimento de um modelo teórico que possa incluir estas duas dimensões. Este estudo tem como principais objectivos desenhar e validar um instrumento de medida das práticas de RSE na indústria farmacêutica chinesa e, utilizando essa escala de medida, avaliar o atual desempenho das empresas chinesas deste setor em termos de práticas de responsabilidade social. Foi utilizada uma metodologia estandardizada para o desenvolvimento de uma escala de medida (entrevistas em profundidade, perguntas abertas, pré-teste ao questionário, validade e fiabilidade do questionário com análises fatoriais exploratória e confirmatória). Foi validada uma escala com 36 itens e oito dimensões (Acionistas, Gestores e Colaboradores; Credores & Fornecedores, Doentes & Médicos; Governo, Ambiente e Comunidade Local) que, de seguida, foram transformadas em três dimensões de segunda ordem: RSE para as partes internas, RSE para os parceiros externos e RSE para as entidades públicas. Este modelo conceptual foi depois aplicado para identificar as particularidades da indústria farmacêutica na China. Os resultados mostram que as práticas de RSE coexistem a níveis muito diferentes: em geral as empresas de capital estrangeiro ou joint ventures apresentam melhor performance que as empresas públicas ou privadas; as empresas maiores revelam mais práticas de RS que as mais pequena