5,401 research outputs found
Accelerated High-Resolution Photoacoustic Tomography via Compressed Sensing
Current 3D photoacoustic tomography (PAT) systems offer either high image
quality or high frame rates but are not able to deliver high spatial and
temporal resolution simultaneously, which limits their ability to image dynamic
processes in living tissue. A particular example is the planar Fabry-Perot (FP)
scanner, which yields high-resolution images but takes several minutes to
sequentially map the photoacoustic field on the sensor plane, point-by-point.
However, as the spatio-temporal complexity of many absorbing tissue structures
is rather low, the data recorded in such a conventional, regularly sampled
fashion is often highly redundant. We demonstrate that combining variational
image reconstruction methods using spatial sparsity constraints with the
development of novel PAT acquisition systems capable of sub-sampling the
acoustic wave field can dramatically increase the acquisition speed while
maintaining a good spatial resolution: First, we describe and model two general
spatial sub-sampling schemes. Then, we discuss how to implement them using the
FP scanner and demonstrate the potential of these novel compressed sensing PAT
devices through simulated data from a realistic numerical phantom and through
measured data from a dynamic experimental phantom as well as from in-vivo
experiments. Our results show that images with good spatial resolution and
contrast can be obtained from highly sub-sampled PAT data if variational image
reconstruction methods that describe the tissues structures with suitable
sparsity-constraints are used. In particular, we examine the use of total
variation regularization enhanced by Bregman iterations. These novel
reconstruction strategies offer new opportunities to dramatically increase the
acquisition speed of PAT scanners that employ point-by-point sequential
scanning as well as reducing the channel count of parallelized schemes that use
detector arrays.Comment: submitted to "Physics in Medicine and Biology
Graphics processing unit accelerating compressed sensing photoacoustic computed tomography with total variation
Photoacoustic computed tomography with compressed sensing (CS-PACT) is a commonly used imaging strategy for sparse-sampling PACT. However, it is very time-consuming because of the iterative process involved in the image reconstruction. In this paper, we present a graphics processing unit (GPU)-based parallel computation framework for total-variation-based CS-PACT and adapted into a custom-made PACT system. Specifically, five compute-intensive operators are extracted from the iteration algorithm and are redesigned for parallel performance on a GPU. We achieved an image reconstruction speed 24–31 times faster than the CPU performance. We performed in vivo experiments on human hands to verify the feasibility of our developed method
Enhancing Compressed Sensing 4D Photoacoustic Tomography by Simultaneous Motion Estimation
A crucial limitation of current high-resolution 3D photoacoustic tomography
(PAT) devices that employ sequential scanning is their long acquisition time.
In previous work, we demonstrated how to use compressed sensing techniques to
improve upon this: images with good spatial resolution and contrast can be
obtained from suitably sub-sampled PAT data acquired by novel acoustic scanning
systems if sparsity-constrained image reconstruction techniques such as total
variation regularization are used. Now, we show how a further increase of image
quality can be achieved for imaging dynamic processes in living tissue (4D
PAT). The key idea is to exploit the additional temporal redundancy of the data
by coupling the previously used spatial image reconstruction models with
sparsity-constrained motion estimation models. While simulated data from a
two-dimensional numerical phantom will be used to illustrate the main
properties of this recently developed
joint-image-reconstruction-and-motion-estimation framework, measured data from
a dynamic experimental phantom will also be used to demonstrate their potential
for challenging, large-scale, real-world, three-dimensional scenarios. The
latter only becomes feasible if a carefully designed combination of tailored
optimization schemes is employed, which we describe and examine in more detail
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