ELICA: An Automated Tool for Dynamic Extraction of Requirements Relevant Information

Requirements elicitation requires extensive knowledge and deep understanding of the problem domain where the final system will be situated. However, in many software development projects, analysts are required to elicit the requirements from an unfamiliar domain, which often causes communication barriers between analysts and stakeholders. In this paper, we propose a requirements ELICitation Aid tool (ELICA) to help analysts better understand the target application domain by dynamic extraction and labeling of requirements-relevant knowledge. To extract the relevant terms, we leverage the flexibility and power of Weighted Finite State Transducers (WFSTs) in dynamic modeling of natural language processing tasks. In addition to the information conveyed through text, ELICA captures and processes non-linguistic information about the intention of speakers such as their confidence level, analytical tone, and emotions. The extracted information is made available to the analysts as a set of labeled snippets with highlighted relevant terms which can also be exported as an artifact of the Requirements Engineering (RE) process. The application and usefulness of ELICA are demonstrated through a case study. This study shows how pre-existing relevant information about the application domain and the information captured during an elicitation meeting, such as the conversation and stakeholders' intentions, can be captured and used to support analysts achieving their tasks.Comment: 2018 IEEE 26th International Requirements Engineering Conference Workshop

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Self-Adaptive Systems for Information Survivability: PMOP and AWDRAT

Information systems form the backbones of the critical infrastructures of modern societies. Unfortunately, these systems are highly vulnerable to attacks that can result in enormous damage. Furthermore, traditional approaches to information security have not provided all the protections necessary to defeat and recover from a concerted attack; in particular, they are largely irrelevant to the problem of defending against attacks launched by insiders.This paper describes two related systems PMOP and AWDRAT that were developed during the DARPA Self Regenerative Systems program. PMOP defends against insider attacks while AWDRAT is intended to detect compromises to software systems. Both rely on self-monitoring, diagnosis and self-adaptation. We describe both systems and show the results of experiments with each

AIRE acetylation and deacetylation: effect on protein stability and transactivation activity

The AIRE protein plays a remarkable role as a regulator of central tolerance by controlling the promiscuous expression of tissue-specific antigens in thymic medullary epithelial cells. Defects in AIRE gene cause the autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy, a rare disease frequent in Iranian Jews, Finns, and Sardinian population. AIRE protein is primarily known as a transcriptional regulator and is capable of interacting with numerous proteins. The first characterized partner of AIRE is the ubiquitous transcription factor CREB-binding protein (CBP), which regulates DNA transcription through the acetylation and deacetylation of histones. More recently, the role of p300 in AIRE acetylation, which could influence the selection of AIRE activated genes, has been described. Results: In this study, we have precisely mapped, by mass spectrometry experiments, the sites of protein acetylation and, by mutagenesis assays, we have described a set of acetylated lysines as being crucial in influencing the subcellular localization of AIRE. Furthermore, we have also determined that the de-acetyltransferase enzymes HDAC1-2 are involved in the lysine de-acetylation of AIRE. Conclusions: On the basis of our results and those reported in literature, we propose a model in which lysines acetylation increases the stability of AIRE in the nucleus. In addition, we observed that the interaction of AIRE with deacetylases complexes inhibits its transcriptional activity and is probably responsible for the instability of AIRE, which becomes more susceptible to degradation in the proteasome

Apeced in Turkey: a case report and insights on genetic and phenotypic variability

APECED is a rare monogenic recessive disorder caused by mutations in the AIRE gene. In this manuscript, we report a male Turkish patient with APECED syndrome who presented with chronic mucocutaneous candidiasis associated with other autoimmune manifestations developed over the years. The presence of the homozygous R257X mutation of the AIRE gene confirmed the diagnosis of APECED syndrome. We further performed literature review in 23 published Turkish APECED patients and noted that Finnish major mutation R257X is common in Turks. In particular, we assessed retrospectively how often the Ferre/Lionakis criteria would have resulted in earlier diagnosis in Finns, Sardinians and Turks in respect to the classic criteria. Since an earlier diagnosis could have been possible in 18.8% of Turkish, in 23.8% of Sardinian and 38.55% of Finnish patients we reviewed from literature, Ferre/Lionakis criteria could indeed allow in future earlier initiation of immunomodulatory treatments, if found effective in future studies

AIRE variations in Addison's disease and autoimmune polyendocrine syndromes (APS):partial gene deletions contribute to APS I

Udgivelsesdato: MarAutoimmune Addison's disease (AAD) is often associated with other components in autoimmune polyendocrine syndromes (APS). Whereas APS I is caused by mutations in the AIRE gene, the susceptibility genes for AAD and APS II are unclear. In the present study, we investigated whether polymorphisms or copy number variations in the AIRE gene were associated with AAD and APS II. First, nine SNPs in the AIRE gene were analyzed in 311 patients with AAD and APS II and 521 healthy controls, identifying no associated risk. Second, in a subgroup of 25 of these patients, AIRE sequencing revealed three novel polymorphisms. Finally, the AIRE copy number was determined by duplex quantitative PCR in 14 patients with APS I, 161 patients with AAD and APS II and in 39 healthy subjects. In two Scandinavian APS I patients previously reported to be homozygous for common AIRE mutations, we identified large deletions of the AIRE gene covering at least exon 2 to exon 8. We conclude that polymorphisms in the AIRE gene are not associated with AAD and APS II. We further suggest that DNA analysis of the parents of patients found to be homozygous for mutations in AIRE, always should be performed

On the Formal Semantics of the Cognitive Middleware AWDRAT

The purpose of this work is two fold: on one hand we want to formalize the behavior of critical components of the self generating and adapting cognitive middleware AWDRAT such that the formalism not only helps to understand the semantics and technical details of the middleware but also opens an opportunity to extend the middleware to support other complex application domains of cybersecurity; on the other hand, the formalism serves as a prerequisite for our proof of the behavioral correctness of the critical components to ensure the safety of the middleware itself. However, here we focus only on the core and critical component of the middleware, i.e. Execution Monitor which is a part of the module "Architectural Differencer" of AWDRAT. The role of the execution monitor is to identify inconsistencies between run-time observations of the target system and predictions of the System Architectural Model. Therefore, to achieve this goal, we first define the formal (denotational) semantics of the observations (run-time events) and predictions (executable specifications as of System Architectural Model); then based on the aforementioned formal semantics, we formalize the behavior of the "Execution Monitor" of the middleware

Demo 6. Caída de cuerpos en ausencia de aire

Objetivo: Demostrar que, en ausencia de aire (vacío parcial de aire), el tiempo de caída de los cuerpos es independiente de su masa o forma