A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis.

Genes central to drug absorption, distribution, metabolism and elimination (ADME) also regulate numerous endogenous molecules. The Remote Sensing and Signaling Hypothesis argues that an ADME gene-centered network-including SLC and ABC "drug" transporters, "drug" metabolizing enzymes (DMEs), and regulatory genes-is essential for inter-organ communication via metabolites, signaling molecules, antioxidants, gut microbiome products, uremic solutes, and uremic toxins. By cross-tissue co-expression network analysis, the gut, liver, and kidney (GLK) formed highly connected tissue-specific clusters of SLC transporters, ABC transporters, and DMEs. SLC22, SLC25 and SLC35 families were network hubs, having more inter-organ and intra-organ connections than other families. Analysis of the GLK network revealed key physiological pathways (e.g., involving bile acids and uric acid). A search for additional genes interacting with the network identified HNF4α, HNF1α, and PXR. Knockout gene expression data confirmed ~60-70% of predictions of ADME gene regulation by these transcription factors. Using the GLK network and known ADME genes, we built a tentative gut-liver-kidney "remote sensing and signaling network" consisting of SLC and ABC transporters, as well as DMEs and regulatory proteins. Together with protein-protein interactions to prioritize likely functional connections, this network suggests how multi-specificity combines with oligo-specificity and mono-specificity to regulate homeostasis of numerous endogenous small molecules

The ghost of Alcestis

This chapter considers a complex of materials centred on the Alcestis of Euripides and its reception history as an opera (Lully, Gluck) in early modern France. The interest of this particular text is that its operatic setting by Lully generated a polemic in the 1670s which initiated the ‘Querelle des anciens et des modernes’, a founding moment of modernity. This study thus interrogates the very notion of ‘ancient’ and ‘modern’ as it is deployed around the Alcestis, that is, as Lully and Gluck translated modernity into music. The fundamental question of this modernity would be ‘Who or what was returned to Admetus?’ My argument is that the ghost of Alcestis, written out, written over, or perhaps repressed the in 1674 Lully opera, re-emerges in the theoretical discourse of Racine and Perrault surrounding the opera as the general question of what, exactly, can be retrieved from antiquity. Equally, her ghostliness eliminated from the plot of Gluck’s 1776 Paris reform opera, it is her voice, her very music, which is invaded by the musical figure of the ghost. The theoretical frame for this study is formed by the notion of ‘hauntology’, a trend in recent critical and psychoanalytical work that attempts to link the theme of the ghost to textuality in general

A Middleware Framework for Constraint-Based Deployment and Autonomic Management of Distributed Applications

We propose a middleware framework for deployment and subsequent autonomic management of component-based distributed applications. An initial deployment goal is specified using a declarative constraint language, expressing constraints over aspects such as component-host mappings and component interconnection topology. A constraint solver is used to find a configuration that satisfies the goal, and the configuration is deployed automatically. The deployed application is instrumented to allow subsequent autonomic management. If, during execution, the manager detects that the original goal is no longer being met, the satisfy/deploy process can be repeated automatically in order to generate a revised deployment that does meet the goal.Comment: Submitted to Middleware 0

A Framework for Constraint-Based Deployment and Autonomic Management of Distributed Applications

We propose a framework for deployment and subsequent autonomic management of component-based distributed applications. An initial deployment goal is specified using a declarative constraint language, expressing constraints over aspects such as component-host mappings and component interconnection topology. A constraint solver is used to find a configuration that satisfies the goal, and the configuration is deployed automatically. The deployed application is instrumented to allow subsequent autonomic management. If, during execution, the manager detects that the original goal is no longer being met, the satisfy/deploy process can be repeated automatically in order to generate a revised deployment that does meet the goal.Comment: Submitted to ICAC-0

Toxicity prediction of anti tuberculosis active molecules

Abstract
The aim of the work was to understand the toxicity, physically significant descriptors and pharmaceutically relevant properties of some imidazoles obtained from the open sources that may found to be active against tuberculosis. At present five azoles were modeled for the prediction and calculation of descriptors that were carried out by means of computational approach [1].
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