Superbugs and Superdrugs: A history of MRSA

Annotated and edited transcript of a Witness Seminar held on 11 July 2006. Introduction by Professor David Greenwood, University of Nottingham.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2008.©The Trustee of the Wellcome Trust, London, 2008.All volumes are freely available online at: www.history.qmul.ac.uk/research/modbiomed/wellcome_witnesses/Annotated and edited transcript of a Witness Seminar held on 11 July 2006. Introduction by Professor David Greenwood, University of Nottingham.Annotated and edited transcript of a Witness Seminar held on 11 July 2006. Introduction by Professor David Greenwood, University of Nottingham.Annotated and edited transcript of a Witness Seminar held on 11 July 2006. Introduction by Professor David Greenwood, University of Nottingham.Annotated and edited transcript of a Witness Seminar held on 11 July 2006. Introduction by Professor David Greenwood, University of Nottingham.Annotated and edited transcript of a Witness Seminar held on 11 July 2006. Introduction by Professor David Greenwood, University of Nottingham.Annotated and edited transcript of a Witness Seminar held on 11 July 2006. Introduction by Professor David Greenwood, University of Nottingham.Because of its unique adaptability and resistance to many antibacterial drugs and antiseptics, methicillin-resistant Staphylococcus aureus (MRSA) is a nosocomial menace of the present day. It has invaded medical and surgical wards in hospitals, infecting patients already ill or recovering, and endangering clean surgical operations, encouraged by overcrowding and limited air circulation. It has now spread from hospitals to families and communities. Infection control microbiologists and the Public Health Laboratory Service developed assays, ‘phage typing and other tests to identify strains, with better understanding of their behaviour aided by the discovery of the mecA gene. This Seminar addressed the biological reasons for this behaviour; the difference between resistant and non-resistant strains; the development, evolution and elucidation of drug resistance in hospital infection and its geographical distribution. Suggested by Professor Gordon Stewart and chaired by Dr Robert Bud, surgeons, microbiologists, infection control experts and representatives of the pharmaceutical industry and of the public included: Professor Graham Ayliffe, Professor Mark Casewell, Dr Bilwanath Chattopadhyay, Dr Stephanie Dancer, Dr Bernard Dixon, Dr Georgia Duckworth, Professor Brian Duerden, Professor Michael Emmerson, Professor Gary French, Professor Curtis Gemmell, Professor Alan Glynn, Dr Ian Gould, Professor David Greenwood, Professor Jeremy Hamilton-Miller, Dr Angela Kearns, Dr Bill Newsom, Professor Ian Phillips, Dr Tyrone Pitt, Dr Elizabeth Price, Professor Sir Mark Richmond, Dr Geoffrey Scott, Dr Joe Selkon, Dr David Shanson, Dr Norman Simmons, Professor Dale Smith, Professor Brian Spratt, Dr Robert Sutherland, Professor John West. Reynolds L A, Tansey E M. (eds) (2008) Superbugs and superdrugs: A history of MRSA, Wellcome Witnesses to Twentieth Century Medicine, vol. 32. London: The Wellcome Trust Centre for the History of Medicine at UCL.The Wellcome Trust Centre for the History of Medicine at UCL is funded by the Wellcome Trust, which is a registered charity, no. 210183

Beyond multimedia adaptation: Quality of experience-aware multi-sensorial media delivery

Multiple sensorial media (mulsemedia) combines multiple media elements which engage three or more of human senses, and as most other media content, requires support for delivery over the existing networks. This paper proposes an adaptive mulsemedia framework (ADAMS) for delivering scalable video and sensorial data to users. Unlike existing two-dimensional joint source-channel adaptation solutions for video streaming, the ADAMS framework includes three joint adaptation dimensions: video source, sensorial source, and network optimization. Using an MPEG-7 description scheme, ADAMS recommends the integration of multiple sensorial effects (i.e., haptic, olfaction, air motion, etc.) as metadata into multimedia streams. ADAMS design includes both coarse- and fine-grained adaptation modules on the server side: mulsemedia flow adaptation and packet priority scheduling. Feedback from subjective quality evaluation and network conditions is used to develop the two modules. Subjective evaluation investigated users' enjoyment levels when exposed to mulsemedia and multimedia sequences, respectively and to study users' preference levels of some sensorial effects in the context of mulsemedia sequences with video components at different quality levels. Results of the subjective study inform guidelines for an adaptive strategy that selects the optimal combination for video segments and sensorial data for a given bandwidth constraint and user requirement. User perceptual tests show how ADAMS outperforms existing multimedia delivery solutions in terms of both user perceived quality and user enjoyment during adaptive streaming of various mulsemedia content. In doing so, it highlights the case for tailored, adaptive mulsemedia delivery over traditional multimedia adaptive transport mechanisms

ATLAS Data Challenge 1

In 2002 the ATLAS experiment started a series of Data Challenges (DC) of which the goals are the validation of the Computing Model, of the complete software suite, of the data model, and to ensure the correctness of the technical choices to be made. A major feature of the first Data Challenge (DC1) was the preparation and the deployment of the software required for the production of large event samples for the High Level Trigger (HLT) and physics communities, and the production of those samples as a world-wide distributed activity. The first phase of DC1 was run during summer 2002, and involved 39 institutes in 18 countries. More than 10 million physics events and 30 million single particle events were fully simulated. Over a period of about 40 calendar days 71000 CPU-days were used producing 30 Tbytes of data in about 35000 partitions. In the second phase the next processing step was performed with the participation of 56 institutes in 21 countries (~ 4000 processors used in parallel). The basic elements of the ATLAS Monte Carlo production system are described. We also present how the software suite was validated and the participating sites were certified. These productions were already partly performed by using different flavours of Grid middleware at ~ 20 sites.Comment: 10 pages; 3 figures; CHEP03 Conference, San Diego; Reference MOCT00

Fire extinguishment in oxygen enriched atmospheres

Current state-of-the-art of fire suppression and extinguishment techniques in oxygen enriched atmosphere is reviewed. Four classes of extinguishment action are considered: cooling, separation of reactants, dilution or removal of fuel, and use of chemically reactive agents. Current practice seems to show preference for very fast acting water spray applications to all interior surfaces of earth-based chambers. In space, reliance has been placed on fire prevention methods through the removal of ignition sources and use of nonflammable materials. Recommendations are made for further work related to fire suppression and extinguishment in oxygen enriched atmospheres, and an extensive bibliography is appended

Space shuttle orbiter auxiliary power unit development challenges

When the flying spacecraft was approved for development, a power unit for the hydraulic system had to be developed. Unlike other systems on the orbiter, there was no precedent in earlier spacecraft for a hydraulic system nor for the power unit to drive the hydraulic pumps. The only prototypes available were airplane auxiliary power units (APU), which were not required to operate in the severe environments of a spacecraft nor to have the longevity of an orbiter hydraulic power unit. The challenge was to build a hydraulic power unit which could operate in 0g or 3g, in a vacuum or at sea level pressure, and at -65 F or 225 F, which would be capable of restarting while hot, and which would be capable of sustaining the hydraulic loads for the life of the orbiter. The basic approach to providing hydraulic power for the orbiter was to use a small, high speed, monopropellant fueled turbine power unit to drive a conventional aircraft type hydraulic pump. The stringent requirements imposed on the orbiter APU quickly made this machine different from existing aircraft APUs

ATTac-2000: An Adaptive Autonomous Bidding Agent

The First Trading Agent Competition (TAC) was held from June 22nd to July 8th, 2000. TAC was designed to create a benchmark problem in the complex domain of e-marketplaces and to motivate researchers to apply unique approaches to a common task. This article describes ATTac-2000, the first-place finisher in TAC. ATTac-2000 uses a principled bidding strategy that includes several elements of adaptivity. In addition to the success at the competition, isolated empirical results are presented indicating the robustness and effectiveness of ATTac-2000's adaptive strategy

Removal of acid gases and oxides of nitrogen from space cabin atmospheres

Removal of acid gases and oxides of nitrogen from spacecraft cabin atmospheres at ambient temperature

A reasonable benchmarking frontier using DEA : an incentive scheme to improve efficiency in public hospitals

There exists research relating management concepts with productivity measurement methods that offers useful solutions for improving management control in the public sector. Within this sphere, we connect agency theory with efficiency analysis and describe how to define an incentives scheme that can be applied in the public sector to monitor the efficiency and productivity of managers. To fulfill the main objective of this research, we propose an iterative process for determining what we define as a ‘reasonable frontier’, a concept that provides the foundation required to establish the incentive scheme for the managers. Our ‘reasonable frontier’ has the following properties: i) it detects the presence of outliers, ii) it proposes a procedure to establish the influence introduced by extreme observations, and iii) it sorts out the problem of data masking. The proposed method is applied to a sample of hospitals taken from the public network of the Spanish health service. The results obtained confirm the applicability of the proposal made. Summing up, we define and apply a useful method, combining aspects of agency theory and efficiency analysis, which is of interest to those public authorities trying to design effective incentive schemes which influence the decision making of the public managers