COMPUTER AIDED SYSTEM FOR BREAST CANCER DIAGNOSIS USING CURVELET TRANSFORM

Breast cancer is a leading cause of death among women worldwide. Early detection is the key for improving breast cancer prognosis. Digital mammography remains one of the most suitable tools for early detection of breast cancer. Hence, there are strong needs for the development of computer aided diagnosis (CAD) systems which have the capability to help radiologists in decision making. The main goal is to increase the diagnostic accuracy rate. In this thesis we developed a computer aided system for the diagnosis and detection of breast cancer using curvelet transform. Curvelet is a multiscale transform which possess directionality and anisotropy, and it breaks some inherent limitations of wavelet in representing edges in images. We started this study by developing a diagnosis system. Five feature extraction methods were developed with curvelet and wavelet coefficients to differentiate between different breast cancer classes. The results with curvelet and wavelet were compared. The experimental results show a high performance of the proposed methods and classification accuracy rate achieved 97.30%. The thesis then provides an automatic system for breast cancer detection. An automatic thresholding algorithm was used to separate the area composed of the breast and the pectoral muscle from the background of the image. Subsequently, a region growing algorithm was used to locate the pectoral muscle and suppress it from the breast. Then, the work concentrates on the segmentation of region of interest (ROI). Two methods are suggested to accomplish the segmentation stage: an adaptive thresholding method and a pattern matching method. Once the ROI has been identified, an automatic cropping is performed to extract it from the original mammogram. Subsequently, the suggested feature extraction methods were applied to the segmented ROIs. Finally, the K-Nearest Neighbor (KNN) and Support Vector Machine (SVM) classifiers were used to determine whether the region is abnormal or normal. At this level, the study focuses on two abnormality types (mammographic masses and architectural distortion). Experimental results show that the introduced methods have very high detection accuracies. The effectiveness of the proposed methods has been tested with Mammographic Image Analysis Society (MIAS) dataset. Throughout the thesis all proposed methods and algorithms have been applied with both curvelet and wavelet for comparison and statistical tests were also performed. The overall results show that curvelet transform performs better than wavelet and the difference is statistically significant

Incorporating Multiresolution Analysis With Multiclassifiers And Decision Fusion For Hyperspectral Remote Sensing

The ongoing development and increased affordability of hyperspectral sensors are increasing their utilization in a variety of applications, such as agricultural monitoring and decision making. Hyperspectral Automated Target Recognition (ATR) systems typically rely heavily on dimensionality reduction methods, and particularly intelligent reduction methods referred to as feature extraction techniques. This dissertation reports on the development, implementation, and testing of new hyperspectral analysis techniques for ATR systems, including their use in agricultural applications where ground truthed observations available for training the ATR system are typically very limited. This dissertation reports the design of effective methods for grouping and down-selecting Discrete Wavelet Transform (DWT) coefficients and the design of automated Wavelet Packet Decomposition (WPD) filter tree pruning methods for use within the framework of a Multiclassifiers and Decision Fusion (MCDF) ATR system. The efficacy of the DWT MCDF and WPD MCDF systems are compared to existing ATR methods commonly used in hyperspectral remote sensing applications. The newly developed methods’ sensitivity to operating conditions, such as mother wavelet selection, decomposition level, and quantity and quality of available training data are also investigated. The newly developed ATR systems are applied to the problem of hyperspectral remote sensing of agricultural food crop contaminations either by airborne chemical application, specifically Glufosinate herbicide at varying concentrations applied to corn crops, or by biological infestation, specifically soybean rust disease in soybean crops. The DWT MCDF and WPD MCDF methods significantly outperform conventional hyperspectral ATR methods. For example, when detecting and classifying varying levels of soybean rust infestation, stepwise linear discriminant analysis, results in accuracies of approximately 30%-40%, but WPD MCDF methods result in accuracies of approximately 70%-80%

Incorporating Multiresolution Analysis With Multiclassifiers And Decision Fusion For Hyperspectral Remote Sensing

The ongoing development and increased affordability of hyperspectral sensors are increasing their utilization in a variety of applications, such as agricultural monitoring and decision making. Hyperspectral Automated Target Recognition (ATR) systems typically rely heavily on dimensionality reduction methods, and particularly intelligent reduction methods referred to as feature extraction techniques. This dissertation reports on the development, implementation, and testing of new hyperspectral analysis techniques for ATR systems, including their use in agricultural applications where ground truthed observations available for training the ATR system are typically very limited. This dissertation reports the design of effective methods for grouping and down-selecting Discrete Wavelet Transform (DWT) coefficients and the design of automated Wavelet Packet Decomposition (WPD) filter tree pruning methods for use within the framework of a Multiclassifiers and Decision Fusion (MCDF) ATR system. The efficacy of the DWT MCDF and WPD MCDF systems are compared to existing ATR methods commonly used in hyperspectral remote sensing applications. The newly developed methods’ sensitivity to operating conditions, such as mother wavelet selection, decomposition level, and quantity and quality of available training data are also investigated. The newly developed ATR systems are applied to the problem of hyperspectral remote sensing of agricultural food crop contaminations either by airborne chemical application, specifically Glufosinate herbicide at varying concentrations applied to corn crops, or by biological infestation, specifically soybean rust disease in soybean crops. The DWT MCDF and WPD MCDF methods significantly outperform conventional hyperspectral ATR methods. For example, when detecting and classifying varying levels of soybean rust infestation, stepwise linear discriminant analysis, results in accuracies of approximately 30%-40%, but WPD MCDF methods result in accuracies of approximately 70%-80%

Histopathological image analysis : a review

Over the past decade, dramatic increases in computational power and improvement in image analysis algorithms have allowed the development of powerful computer-assisted analytical approaches to radiological data. With the recent advent of whole slide digital scanners, tissue histopathology slides can now be digitized and stored in digital image form. Consequently, digitized tissue histopathology has now become amenable to the application of computerized image analysis and machine learning techniques. Analogous to the role of computer-assisted diagnosis (CAD) algorithms in medical imaging to complement the opinion of a radiologist, CAD algorithms have begun to be developed for disease detection, diagnosis, and prognosis prediction to complement the opinion of the pathologist. In this paper, we review the recent state of the art CAD technology for digitized histopathology. This paper also briefly describes the development and application of novel image analysis technology for a few specific histopathology related problems being pursued in the United States and Europe

Detecting microcalcification clusters in digital mammograms: Study for inclusion into computer aided diagnostic prompting system

Among signs of breast cancer encountered in digital mammograms radiologists point to microcalcification clusters (MCCs). Their detection is a challenging problem from both medical and image processing point of views. This work presents two concurrent methods for MCC detection, and studies their possible inclusion to a computer aided diagnostic prompting system. One considers Wavelet Domain Hidden Markov Tree (WHMT) for modeling microcalcification edges. The model is used for differentiation between MC and non-MC edges based on the weighted maximum likelihood (WML) values. The classification of objects is carried out using spatial filters. The second method employs SUSAN edge detector in the spatial domain for mammogram segmentation. Classification of objects as calcifications is carried out using another set of spatial filters and Feedforward Neural Network (NN). A same distance filter is employed in both methods to find true clusters. The analysis of two methods is performed on 54 image regions from the mammograms selected randomly from DDSM database, including benign and cancerous cases as well as cases which can be classified as hard cases from both radiologists and the computer perspectives. WHMT/WML is able to detect 98.15% true positive (TP) MCCs under 1.85% of false positives (FP), whereas the SUSAN/NN method achieves 94.44% of TP at the cost of 1.85% for FP. The comparison of these two methods suggests WHMT/WML for the computer aided diagnostic prompting. It also certifies the low false positive rates for both methods, meaning less biopsy tests per patient

Strategies for neural networks in ballistocardiography with a view towards hardware implementation

A thesis submitted for the degree of Doctor of Philosophy at the University of LutonThe work described in this thesis is based on the results of a clinical trial conducted by the research team at the Medical Informatics Unit of the University of Cambridge, which show that the Ballistocardiogram (BCG) has prognostic value in detecting impaired left ventricular function before it becomes clinically overt as myocardial infarction leading to sudden death. The objective of this study is to develop and demonstrate a framework for realising an on-line BCG signal classification model in a portable device that would have the potential to find pathological signs as early as possible for home health care. Two new on-line automatic BeG classification models for time domain BeG classification are proposed. Both systems are based on a two stage process: input feature extraction followed by a neural classifier. One system uses a principal component analysis neural network, and the other a discrete wavelet transform, to reduce the input dimensionality. Results of the classification, dimensionality reduction, and comparison are presented. It is indicated that the combined wavelet transform and MLP system has a more reliable performance than the combined neural networks system, in situations where the data available to determine the network parameters is limited. Moreover, the wavelet transfonn requires no prior knowledge of the statistical distribution of data samples and the computation complexity and training time are reduced. Overall, a methodology for realising an automatic BeG classification system for a portable instrument is presented. A fully paralJel neural network design for a low cost platform using field programmable gate arrays (Xilinx's XC4000 series) is explored. This addresses the potential speed requirements in the biomedical signal processing field. It also demonstrates a flexible hardware design approach so that an instrument's parameters can be updated as data expands with time. To reduce the hardware design complexity and to increase the system performance, a hybrid learning algorithm using random optimisation and the backpropagation rule is developed to achieve an efficient weight update mechanism in low weight precision learning. The simulation results show that the hybrid learning algorithm is effective in solving the network paralysis problem and the convergence is much faster than by the standard backpropagation rule. The hidden and output layer nodes have been mapped on Xilinx FPGAs with automatic placement and routing tools. The static time analysis results suggests that the proposed network implementation could generate 2.7 billion connections per second performance

Mapping and monitoring forest remnants : a multiscale analysis of spatio-temporal data

KEYWORDS : Landsat, time series, machine learning, semideciduous Atlantic forest, Brazil, wavelet transforms, classification, change detectionForests play a major role in important global matters such as carbon cycle, climate change, and biodiversity. Besides, forests also influence soil and water dynamics with major consequences for ecological relations and decision-making. One basic requirement to quantify and model these processes is the availability of accurate maps of forest cover. Data acquisition and analysis at appropriate scales is the keystone to achieve the mapping accuracy needed for development and reliable use of ecological models.The current and upcoming production of high-resolution data sets plus the ever-increasing time series that have been collected since the seventieth must be effectively explored. Missing values and distortions further complicate the analysis of this data set. Thus, integration and proper analysis is of utmost importance for environmental research. New conceptual models in environmental sciences, like the perception of multiple scales, require the development of effective implementation techniques.This thesis presents new methodologies to map and monitor forests on large, highly fragmented areas with complex land use patterns. The use of temporal information is extensively explored to distinguish natural forests from other land cover types that are spectrally similar. In chapter 4, novel schemes based on multiscale wavelet analysis are introduced, which enabled an effective preprocessing of long time series of Landsat data and improved its applicability on environmental assessment.In chapter 5, the produced time series as well as other information on spectral and spatial characteristics were used to classify forested areas in an experiment relating a number of combinations of attribute features. Feature sets were defined based on expert knowledge and on data mining techniques to be input to traditional and machine learning algorithms for pattern recognition, viz . maximum likelihood, univariate and multivariate decision trees, and neural networks. The results showed that maximum likelihood classification using temporal texture descriptors as extracted with wavelet transforms was most accurate to classify the semideciduous Atlantic forest in the study area.In chapter 6, a multiscale approach to digital change detection was developed to deal with multisensor and noisy remotely sensed images. Changes were extracted according to size classes minimising the effects of geometric and radiometric misregistration.Finally, in chapter 7, an automated procedure for GIS updating based on feature extraction, segmentation and classification was developed to monitor the remnants of semideciduos Atlantic forest. The procedure showed significant improvements over post classification comparison and direct multidate classification based on artificial neural networks.</p

Imaging time series for the classification of EMI discharge sources

In this work, we aim to classify a wider range of Electromagnetic Interference (EMI) discharge sources collected from new power plant sites across multiple assets. This engenders a more complex and challenging classification task. The study involves an investigation and development of new and improved feature extraction and data dimension reduction algorithms based on image processing techniques. The approach is to exploit the Gramian Angular Field technique to map the measured EMI time signals to an image, from which the significant information is extracted while removing redundancy. The image of each discharge type contains a unique fingerprint. Two feature reduction methods called the Local Binary Pattern (LBP) and the Local Phase Quantisation (LPQ) are then used within the mapped images. This provides feature vectors that can be implemented into a Random Forest (RF) classifier. The performance of a previous and the two new proposed methods, on the new database set, is compared in terms of classification accuracy, precision, recall, and F-measure. Results show that the new methods have a higher performance than the previous one, where LBP features achieve the best outcome