Binary and nonbinary description of hypointensity for search and retrieval of brain MR images

Diagnosis accuracy in the medical field, is mainly affected by either lack of sufficient understanding of some diseases or the inter/intra-observer variability of the diagnoses. We believe that mining of large medical databases can help improve the current status of disease understanding and decision making. In a previous study based on binary description of hypointensity in the brain, it was shown that brain iron accumulation shape provides additional information to the shape-insensitive features, such as the total brain iron load, that are commonly used in clinics. This paper proposes a novel, nonbinary description of hypointensity in the brain based on principal component analysis. We compare the complementary and redundant information provided by the two descriptions using Kendall's rank correlation coefficient in order to better understand the individual descriptions of iron accumulation in the brain and obtain a more robust and accurate search and retrieval system

A Study of Metrics of Distance and Correlation Between Ranked Lists for Compositionality Detection

Compositionality in language refers to how much the meaning of some phrase can be decomposed into the meaning of its constituents and the way these constituents are combined. Based on the premise that substitution by synonyms is meaning-preserving, compositionality can be approximated as the semantic similarity between a phrase and a version of that phrase where words have been replaced by their synonyms. Different ways of representing such phrases exist (e.g., vectors [1] or language models [2]), and the choice of representation affects the measurement of semantic similarity. We propose a new compositionality detection method that represents phrases as ranked lists of term weights. Our method approximates the semantic similarity between two ranked list representations using a range of well-known distance and correlation metrics. In contrast to most state-of-the-art approaches in compositionality detection, our method is completely unsupervised. Experiments with a publicly available dataset of 1048 human-annotated phrases shows that, compared to strong supervised baselines, our approach provides superior measurement of compositionality using any of the distance and correlation metrics considered

PageRank and rank-reversal dependence on the damping factor

PageRank (PR) is an algorithm originally developed by Google to evaluate the importance of web pages. Considering how deeply rooted Google's PR algorithm is to gathering relevant information or to the success of modern businesses, the question of rank-stability and choice of the damping factor (a parameter in the algorithm) is clearly important. We investigate PR as a function of the damping factor d on a network obtained from a domain of the World Wide Web, finding that rank-reversal happens frequently over a broad range of PR (and of d). We use three different correlation measures, Pearson, Spearman, and Kendall, to study rank-reversal as d changes, and show that the correlation of PR vectors drops rapidly as d changes from its frequently cited value, $d_0=0.85$. Rank-reversal is also observed by measuring the Spearman and Kendall rank correlation, which evaluate relative ranks rather than absolute PR. Rank-reversal happens not only in directed networks containing rank-sinks but also in a single strongly connected component, which by definition does not contain any sinks. We relate rank-reversals to rank-pockets and bottlenecks in the directed network structure. For the network studied, the relative rank is more stable by our measures around $d=0.65$ than at $d=d_0$.Comment: 14 pages, 9 figure

Evaluating implicit feedback models using searcher simulations

In this article we describe an evaluation of relevance feedback (RF) algorithms using searcher simulations. Since these algorithms select additional terms for query modification based on inferences made from searcher interaction, not on relevance information searchers explicitly provide (as in traditional RF), we refer to them as implicit feedback models. We introduce six different models that base their decisions on the interactions of searchers and use different approaches to rank query modification terms. The aim of this article is to determine which of these models should be used to assist searchers in the systems we develop. To evaluate these models we used searcher simulations that afforded us more control over the experimental conditions than experiments with human subjects and allowed complex interaction to be modeled without the need for costly human experimentation. The simulation-based evaluation methodology measures how well the models learn the distribution of terms across relevant documents (i.e., learn what information is relevant) and how well they improve search effectiveness (i.e., create effective search queries). Our findings show that an implicit feedback model based on Jeffrey's rule of conditioning outperformed other models under investigation

The study of probability model for compound similarity searching

Information Retrieval or IR system main task is to retrieve relevant documents according to the users query. One of IR most popular retrieval model is the Vector Space Model. This model assumes relevance based on similarity, which is defined as the distance between query and document in the concept space. All currently existing chemical compound database systems have adapt the vector space model to calculate the similarity of a database entry to a query compound. However, it assumes that fragments represented by the bits are independent of one another, which is not necessarily true. Hence, the possibility of applying another IR model is explored, which is the Probabilistic Model, for chemical compound searching. This model estimates the probabilities of a chemical structure to have the same bioactivity as a target compound. It is envisioned that by ranking chemical structures in decreasing order of their probability of relevance to the query structure, the effectiveness of a molecular similarity searching system can be increased. Both fragment dependencies and independencies assumption are taken into consideration in achieving improvement towards compound similarity searching system. After conducting a series of simulated similarity searching, it is concluded that PM approaches really did perform better than the existing similarity searching. It gave better result in all evaluation criteria to confirm this statement. In terms of which probability model performs better, the BD model shown improvement over the BIR model