Joint Total Variation ESTATICS for Robust Multi-Parameter Mapping

Quantitative magnetic resonance imaging (qMRI) derives tissue-specific parameters -- such as the apparent transverse relaxation rate R2*, the longitudinal relaxation rate R1 and the magnetisation transfer saturation -- that can be compared across sites and scanners and carry important information about the underlying microstructure. The multi-parameter mapping (MPM) protocol takes advantage of multi-echo acquisitions with variable flip angles to extract these parameters in a clinically acceptable scan time. In this context, ESTATICS performs a joint loglinear fit of multiple echo series to extract R2* and multiple extrapolated intercepts, thereby improving robustness to motion and decreasing the variance of the estimators. In this paper, we extend this model in two ways: (1) by introducing a joint total variation (JTV) prior on the intercepts and decay, and (2) by deriving a nonlinear maximum \emph{a posteriori} estimate. We evaluated the proposed algorithm by predicting left-out echoes in a rich single-subject dataset. In this validation, we outperformed other state-of-the-art methods and additionally showed that the proposed approach greatly reduces the variance of the estimated maps, without introducing bias.Comment: 11 pages, 2 figures, 1 table, conference paper, accepted at MICCAI 202

Perturbation of the Eigenvectors of the Graph Laplacian: Application to Image Denoising

The original contributions of this paper are twofold: a new understanding of the influence of noise on the eigenvectors of the graph Laplacian of a set of image patches, and an algorithm to estimate a denoised set of patches from a noisy image. The algorithm relies on the following two observations: (1) the low-index eigenvectors of the diffusion, or graph Laplacian, operators are very robust to random perturbations of the weights and random changes in the connections of the patch-graph; and (2) patches extracted from smooth regions of the image are organized along smooth low-dimensional structures in the patch-set, and therefore can be reconstructed with few eigenvectors. Experiments demonstrate that our denoising algorithm outperforms the denoising gold-standards

High Quality Image Interpolation via Local Autoregressive and Nonlocal 3-D Sparse Regularization

In this paper, we propose a novel image interpolation algorithm, which is formulated via combining both the local autoregressive (AR) model and the nonlocal adaptive 3-D sparse model as regularized constraints under the regularization framework. Estimating the high-resolution image by the local AR regularization is different from these conventional AR models, which weighted calculates the interpolation coefficients without considering the rough structural similarity between the low-resolution (LR) and high-resolution (HR) images. Then the nonlocal adaptive 3-D sparse model is formulated to regularize the interpolated HR image, which provides a way to modify these pixels with the problem of numerical stability caused by AR model. In addition, a new Split-Bregman based iterative algorithm is developed to solve the above optimization problem iteratively. Experiment results demonstrate that the proposed algorithm achieves significant performance improvements over the traditional algorithms in terms of both objective quality and visual perceptionComment: 4 pages, 5 figures, 2 tables, to be published at IEEE Visual Communications and Image Processing (VCIP) 201