Solving multiple sequence alignment problems by using a swarm intelligent optimization based approach

In this article, the alignment of multiple sequences is examined through swarm intelligence based an improved particle swarm optimization (PSO). A random heuristic technique for solving discrete optimization problems and realistic estimation was recently discovered in PSO. The PSO approach is a nature-inspired technique based on intelligence and swarm movement. Thus, each solution is encoded as “chromosomes” in the genetic algorithm (GA). Based on the optimization of the objective function, the fitness function is designed to maximize the suitable components of the sequence and reduce the unsuitable components of the sequence. The availability of a public benchmark data set such as the Bali base is seen as an assessment of the proposed system performance, with the potential for PSO to reveal problems in adapting to better performance. This proposed system is compared with few existing approaches such as deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) alignment (DIALIGN), PILEUP8, hidden Markov model training (HMMT), rubber band technique-genetic algorithm (RBT-GA) and ML-PIMA. In many cases, the experimental results are well implemented in the proposed system compared to other existing approaches

On the role of metaheuristic optimization in bioinformatics

Metaheuristic algorithms are employed to solve complex and large-scale optimization problems in many different fields, from transportation and smart cities to finance. This paper discusses how metaheuristic algorithms are being applied to solve different optimization problems in the area of bioinformatics. While the text provides references to many optimization problems in the area, it focuses on those that have attracted more interest from the optimization community. Among the problems analyzed, the paper discusses in more detail the molecular docking problem, the protein structure prediction, phylogenetic inference, and different string problems. In addition, references to other relevant optimization problems are also given, including those related to medical imaging or gene selection for classification. From the previous analysis, the paper generates insights on research opportunities for the Operations Research and Computer Science communities in the field of bioinformatics