On the Use of XML in Medical Imaging Web-Based Applications

The rapid growth of digital technology in medical fields over recent years has increased the need for applications able to manage patient medical records, imaging data, and chart information. Web-based applications are implemented with the purpose to link digital databases, storage and transmission protocols, management of large volumes of data and security concepts, allowing the possibility to read, analyze, and even diagnose remotely from the medical center where the information was acquired. The objective of this paper is to analyze the use of the Extensible Markup Language (XML) language in web-based applications that aid in diagnosis or treatment of patients, considering how this protocol allows indexing and exchanging the huge amount of information associated with each medical case. The purpose of this paper is to point out the main advantages and drawbacks of the XML technology in order to provide key ideas for future web-based applicationsPeer ReviewedPostprint (author's final draft

Privacy-preserving data sharing infrastructures for medical research: systematization and comparison

Background: Data sharing is considered a crucial part of modern medical research. Unfortunately, despite its advantages, it often faces obstacles, especially data privacy challenges. As a result, various approaches and infrastructures have been developed that aim to ensure that patients and research participants remain anonymous when data is shared. However, privacy protection typically comes at a cost, e.g. restrictions regarding the types of analyses that can be performed on shared data. What is lacking is a systematization making the trade-offs taken by different approaches transparent. The aim of the work described in this paper was to develop a systematization for the degree of privacy protection provided and the trade-offs taken by different data sharing methods. Based on this contribution, we categorized popular data sharing approaches and identified research gaps by analyzing combinations of promising properties and features that are not yet supported by existing approaches. Methods: The systematization consists of different axes. Three axes relate to privacy protection aspects and were adopted from the popular Five Safes Framework: (1) safe data, addressing privacy at the input level, (2) safe settings, addressing privacy during shared processing, and (3) safe outputs, addressing privacy protection of analysis results. Three additional axes address the usefulness of approaches: (4) support for de-duplication, to enable the reconciliation of data belonging to the same individuals, (5) flexibility, to be able to adapt to different data analysis requirements, and (6) scalability, to maintain performance with increasing complexity of shared data or common analysis processes. Results: Using the systematization, we identified three different categories of approaches: distributed data analyses, which exchange anonymous aggregated data, secure multi-party computation protocols, which exchange encrypted data, and data enclaves, which store pooled individual-level data in secure environments for access for analysis purposes. We identified important research gaps, including a lack of approaches enabling the de-duplication of horizontally distributed data or providing a high degree of flexibility. Conclusions: There are fundamental differences between different data sharing approaches and several gaps in their functionality that may be interesting to investigate in future work. Our systematization can make the properties of privacy-preserving data sharing infrastructures more transparent and support decision makers and regulatory authorities with a better understanding of the trade-offs taken

Are Chatbots Ready for Privacy-Sensitive Applications? An Investigation into Input Regurgitation and Prompt-Induced Sanitization

LLM-powered chatbots are becoming widely adopted in applications such as healthcare, personal assistants, industry hiring decisions, etc. In many of these cases, chatbots are fed sensitive, personal information in their prompts, as samples for in-context learning, retrieved records from a database, or as part of the conversation. The information provided in the prompt could directly appear in the output, which might have privacy ramifications if there is sensitive information there. As such, in this paper, we aim to understand the input copying and regurgitation capabilities of these models during inference and how they can be directly instructed to limit this copying by complying with regulations such as HIPAA and GDPR, based on their internal knowledge of them. More specifically, we find that when ChatGPT is prompted to summarize cover letters of a 100 candidates, it would retain personally identifiable information (PII) verbatim in 57.4% of cases, and we find this retention to be non-uniform between different subgroups of people, based on attributes such as gender identity. We then probe ChatGPT's perception of privacy-related policies and privatization mechanisms by directly instructing it to provide compliant outputs and observe a significant omission of PII from output.Comment: 12 pages, 9 figures, and 4 table