22,872 research outputs found
Dissimilarity-based representation for radiomics applications
Radiomics is a term which refers to the analysis of the large amount of
quantitative tumor features extracted from medical images to find useful
predictive, diagnostic or prognostic information. Many recent studies have
proved that radiomics can offer a lot of useful information that physicians
cannot extract from the medical images and can be associated with other
information like gene or protein data. However, most of the classification
studies in radiomics report the use of feature selection methods without
identifying the machine learning challenges behind radiomics. In this paper, we
first show that the radiomics problem should be viewed as an high dimensional,
low sample size, multi view learning problem, then we compare different
solutions proposed in multi view learning for classifying radiomics data. Our
experiments, conducted on several real world multi view datasets, show that the
intermediate integration methods work significantly better than filter and
embedded feature selection methods commonly used in radiomics.Comment: conference, 6 pages, 2 figure
Kernel methods in genomics and computational biology
Support vector machines and kernel methods are increasingly popular in
genomics and computational biology, due to their good performance in real-world
applications and strong modularity that makes them suitable to a wide range of
problems, from the classification of tumors to the automatic annotation of
proteins. Their ability to work in high dimension, to process non-vectorial
data, and the natural framework they provide to integrate heterogeneous data
are particularly relevant to various problems arising in computational biology.
In this chapter we survey some of the most prominent applications published so
far, highlighting the particular developments in kernel methods triggered by
problems in biology, and mention a few promising research directions likely to
expand in the future
Elephant Search with Deep Learning for Microarray Data Analysis
Even though there is a plethora of research in Microarray gene expression
data analysis, still, it poses challenges for researchers to effectively and
efficiently analyze the large yet complex expression of genes. The feature
(gene) selection method is of paramount importance for understanding the
differences in biological and non-biological variation between samples. In
order to address this problem, a novel elephant search (ES) based optimization
is proposed to select best gene expressions from the large volume of microarray
data. Further, a promising machine learning method is envisioned to leverage
such high dimensional and complex microarray dataset for extracting hidden
patterns inside to make a meaningful prediction and most accurate
classification. In particular, stochastic gradient descent based Deep learning
(DL) with softmax activation function is then used on the reduced features
(genes) for better classification of different samples according to their gene
expression levels. The experiments are carried out on nine most popular Cancer
microarray gene selection datasets, obtained from UCI machine learning
repository. The empirical results obtained by the proposed elephant search
based deep learning (ESDL) approach are compared with most recent published
article for its suitability in future Bioinformatics research.Comment: 12 pages, 5 Tabl
Stable Feature Selection for Biomarker Discovery
Feature selection techniques have been used as the workhorse in biomarker
discovery applications for a long time. Surprisingly, the stability of feature
selection with respect to sampling variations has long been under-considered.
It is only until recently that this issue has received more and more attention.
In this article, we review existing stable feature selection methods for
biomarker discovery using a generic hierarchal framework. We have two
objectives: (1) providing an overview on this new yet fast growing topic for a
convenient reference; (2) categorizing existing methods under an expandable
framework for future research and development
A Reduction of the Elastic Net to Support Vector Machines with an Application to GPU Computing
The past years have witnessed many dedicated open-source projects that built
and maintain implementations of Support Vector Machines (SVM), parallelized for
GPU, multi-core CPUs and distributed systems. Up to this point, no comparable
effort has been made to parallelize the Elastic Net, despite its popularity in
many high impact applications, including genetics, neuroscience and systems
biology. The first contribution in this paper is of theoretical nature. We
establish a tight link between two seemingly different algorithms and prove
that Elastic Net regression can be reduced to SVM with squared hinge loss
classification. Our second contribution is to derive a practical algorithm
based on this reduction. The reduction enables us to utilize prior efforts in
speeding up and parallelizing SVMs to obtain a highly optimized and parallel
solver for the Elastic Net and Lasso. With a simple wrapper, consisting of only
11 lines of MATLAB code, we obtain an Elastic Net implementation that naturally
utilizes GPU and multi-core CPUs. We demonstrate on twelve real world data
sets, that our algorithm yields identical results as the popular (and highly
optimized) glmnet implementation but is one or several orders of magnitude
faster.Comment: 10 page
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