Indirect Detection of Forming Protoplanets via Chemical Asymmetries in Disks

We examine changes in the molecular abundances resulting from increased heating due to a self-luminous planetary companion embedded within a narrow circumstellar disk gap. Using 3D models that include stellar and planetary irradiation, we find that luminous young planets locally heat up the parent circumstellar disk by many tens of Kelvin, resulting in efficient thermal desorption of molecular species that are otherwise locally frozen out. Furthermore, the heating is deposited over large regions of the disk, $\pm5$ AU radially and spanning $\lesssim60^\circ$ azimuthally. From the 3D chemical models, we compute rotational line emission models and full ALMA simulations, and find that the chemical signatures of the young planet are detectable as chemical asymmetries in $\sim10h$ observations. HCN and its isotopologues are particularly clear tracers of planetary heating for the models considered here, and emission from multiple transitions of the same species is detectable, which encodes temperature information in addition to possible velocity information from the spectra itself. We find submillimeter molecular emission will be a useful tool to study gas giant planet formation in situ, especially beyond $R\gtrsim10$ AU.Comment: 14 pages, 14 figures, accepted for publication in Ap

Exploring the potential of 3D Zernike descriptors and SVM for protein\u2013protein interface prediction

Abstract Background The correct determination of protein–protein interaction interfaces is important for understanding disease mechanisms and for rational drug design. To date, several computational methods for the prediction of protein interfaces have been developed, but the interface prediction problem is still not fully understood. Experimental evidence suggests that the location of binding sites is imprinted in the protein structure, but there are major differences among the interfaces of the various protein types: the characterising properties can vary a lot depending on the interaction type and function. The selection of an optimal set of features characterising the protein interface and the development of an effective method to represent and capture the complex protein recognition patterns are of paramount importance for this task. Results In this work we investigate the potential of a novel local surface descriptor based on 3D Zernike moments for the interface prediction task. Descriptors invariant to roto-translations are extracted from circular patches of the protein surface enriched with physico-chemical properties from the HQI8 amino acid index set, and are used as samples for a binary classification problem. Support Vector Machines are used as a classifier to distinguish interface local surface patches from non-interface ones. The proposed method was validated on 16 classes of proteins extracted from the Protein–Protein Docking Benchmark 5.0 and compared to other state-of-the-art protein interface predictors (SPPIDER, PrISE and NPS-HomPPI). Conclusions The 3D Zernike descriptors are able to capture the similarity among patterns of physico-chemical and biochemical properties mapped on the protein surface arising from the various spatial arrangements of the underlying residues, and their usage can be easily extended to other sets of amino acid properties. The results suggest that the choice of a proper set of features characterising the protein interface is crucial for the interface prediction task, and that optimality strongly depends on the class of proteins whose interface we want to characterise. We postulate that different protein classes should be treated separately and that it is necessary to identify an optimal set of features for each protein class

Privacy-Preserving Facial Recognition Using Biometric-Capsules

Indiana University-Purdue University Indianapolis (IUPUI)In recent years, developers have used the proliferation of biometric sensors in smart devices, along with recent advances in deep learning, to implement an array of biometrics-based recognition systems. Though these systems demonstrate remarkable performance and have seen wide acceptance, they present unique and pressing security and privacy concerns. One proposed method which addresses these concerns is the elegant, fusion-based Biometric-Capsule (BC) scheme. The BC scheme is provably secure, privacy-preserving, cancellable and interoperable in its secure feature fusion design. In this work, we demonstrate that the BC scheme is uniquely fit to secure state-of-the-art facial verification, authentication and identification systems. We compare the performance of unsecured, underlying biometrics systems to the performance of the BC-embedded systems in order to directly demonstrate the minimal effects of the privacy-preserving BC scheme on underlying system performance. Notably, we demonstrate that, when seamlessly embedded into a state-of-the-art FaceNet and ArcFace verification systems which achieve accuracies of 97.18% and 99.75% on the benchmark LFW dataset, the BC-embedded systems are able to achieve accuracies of 95.13% and 99.13% respectively. Furthermore, we also demonstrate that the BC scheme outperforms or performs as well as several other proposed secure biometric methods

Attention to attributes and objects in working memory

It has been debated on the basis of change-detection procedures whether visual working memory is limited by the number of objects, task-relevant attributes within those objects, or bindings between attributes. This debate, however, has been hampered by several limitations, including the use of conditions that vary between studies and the absence of appropriate mathematical models to estimate the number of items in working memory in different stimulus conditions. We re-examined working memory limits in two experiments with a wide array of conditions involving color and shape attributes, relying on a set of new models to fit various stimulus situations. In Experiment 2, a new procedure allowed identical retrieval conditions across different conditions of attention at encoding. The results show that multiple attributes compete for attention, but that retaining the binding between attributes is accomplished only by retaining the attributes themselves. We propose a theoretical account in which a fixed object capacity limit contains within it the possibility of the incomplete retention of object attributes, depending on the direction of attention

Perceptual Pluralism

Perceptual systems respond to proximal stimuli by forming mental representations of distal stimuli. A central goal for the philosophy of perception is to characterize the representations delivered by perceptual systems. It may be that all perceptual representations are in some way proprietarily perceptual and differ from the representational format of thought (Dretske 1981; Carey 2009; Burge 2010; Block ms.). Or it may instead be that perception and cognition always trade in the same code (Prinz 2002; Pylyshyn 2003). This paper rejects both approaches in favor of perceptual pluralism, the thesis that perception delivers a multiplicity of representational formats, some proprietary and some shared with cognition. The argument for perceptual pluralism marshals a wide array of empirical evidence in favor of iconic (i.e., image-like, analog) representations in perception as well as discursive (i.e., language-like, digital) perceptual object representations