18,618 research outputs found
A cDNA Microarray Gene Expression Data Classifier for Clinical Diagnostics Based on Graph Theory
Despite great advances in discovering cancer molecular profiles, the proper application of microarray technology to routine clinical diagnostics is still a challenge. Current practices in the classification of microarrays' data show two main limitations: the reliability of the training data sets used to build the classifiers, and the classifiers' performances, especially when the sample to be classified does not belong to any of the available classes. In this case, state-of-the-art algorithms usually produce a high rate of false positives that, in real diagnostic applications, are unacceptable. To address this problem, this paper presents a new cDNA microarray data classification algorithm based on graph theory and is able to overcome most of the limitations of known classification methodologies. The classifier works by analyzing gene expression data organized in an innovative data structure based on graphs, where vertices correspond to genes and edges to gene expression relationships. To demonstrate the novelty of the proposed approach, the authors present an experimental performance comparison between the proposed classifier and several state-of-the-art classification algorithm
Improving Sparse Representation-Based Classification Using Local Principal Component Analysis
Sparse representation-based classification (SRC), proposed by Wright et al.,
seeks the sparsest decomposition of a test sample over the dictionary of
training samples, with classification to the most-contributing class. Because
it assumes test samples can be written as linear combinations of their
same-class training samples, the success of SRC depends on the size and
representativeness of the training set. Our proposed classification algorithm
enlarges the training set by using local principal component analysis to
approximate the basis vectors of the tangent hyperplane of the class manifold
at each training sample. The dictionary in SRC is replaced by a local
dictionary that adapts to the test sample and includes training samples and
their corresponding tangent basis vectors. We use a synthetic data set and
three face databases to demonstrate that this method can achieve higher
classification accuracy than SRC in cases of sparse sampling, nonlinear class
manifolds, and stringent dimension reduction.Comment: Published in "Computational Intelligence for Pattern Recognition,"
editors Shyi-Ming Chen and Witold Pedrycz. The original publication is
available at http://www.springerlink.co
Dimension Reduction by Mutual Information Discriminant Analysis
In the past few decades, researchers have proposed many discriminant analysis
(DA) algorithms for the study of high-dimensional data in a variety of
problems. Most DA algorithms for feature extraction are based on
transformations that simultaneously maximize the between-class scatter and
minimize the withinclass scatter matrices. This paper presents a novel DA
algorithm for feature extraction using mutual information (MI). However, it is
not always easy to obtain an accurate estimation for high-dimensional MI. In
this paper, we propose an efficient method for feature extraction that is based
on one-dimensional MI estimations. We will refer to this algorithm as mutual
information discriminant analysis (MIDA). The performance of this proposed
method was evaluated using UCI databases. The results indicate that MIDA
provides robust performance over different data sets with different
characteristics and that MIDA always performs better than, or at least
comparable to, the best performing algorithms.Comment: 13pages, 3 tables, International Journal of Artificial Intelligence &
Application
One-class classifiers based on entropic spanning graphs
One-class classifiers offer valuable tools to assess the presence of outliers
in data. In this paper, we propose a design methodology for one-class
classifiers based on entropic spanning graphs. Our approach takes into account
the possibility to process also non-numeric data by means of an embedding
procedure. The spanning graph is learned on the embedded input data and the
outcoming partition of vertices defines the classifier. The final partition is
derived by exploiting a criterion based on mutual information minimization.
Here, we compute the mutual information by using a convenient formulation
provided in terms of the -Jensen difference. Once training is
completed, in order to associate a confidence level with the classifier
decision, a graph-based fuzzy model is constructed. The fuzzification process
is based only on topological information of the vertices of the entropic
spanning graph. As such, the proposed one-class classifier is suitable also for
data characterized by complex geometric structures. We provide experiments on
well-known benchmarks containing both feature vectors and labeled graphs. In
addition, we apply the method to the protein solubility recognition problem by
considering several representations for the input samples. Experimental results
demonstrate the effectiveness and versatility of the proposed method with
respect to other state-of-the-art approaches.Comment: Extended and revised version of the paper "One-Class Classification
Through Mutual Information Minimization" presented at the 2016 IEEE IJCNN,
Vancouver, Canad
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