3,520 research outputs found
State-space solutions to the dynamic magnetoencephalography inverse problem using high performance computing
Determining the magnitude and location of neural sources within the brain
that are responsible for generating magnetoencephalography (MEG) signals
measured on the surface of the head is a challenging problem in functional
neuroimaging. The number of potential sources within the brain exceeds by an
order of magnitude the number of recording sites. As a consequence, the
estimates for the magnitude and location of the neural sources will be
ill-conditioned because of the underdetermined nature of the problem. One
well-known technique designed to address this imbalance is the minimum norm
estimator (MNE). This approach imposes an regularization constraint that
serves to stabilize and condition the source parameter estimates. However,
these classes of regularizer are static in time and do not consider the
temporal constraints inherent to the biophysics of the MEG experiment. In this
paper we propose a dynamic state-space model that accounts for both spatial and
temporal correlations within and across candidate intracortical sources. In our
model, the observation model is derived from the steady-state solution to
Maxwell's equations while the latent model representing neural dynamics is
given by a random walk process.Comment: Published in at http://dx.doi.org/10.1214/11-AOAS483 the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
Multichannel sparse recovery of complex-valued signals using Huber's criterion
In this paper, we generalize Huber's criterion to multichannel sparse
recovery problem of complex-valued measurements where the objective is to find
good recovery of jointly sparse unknown signal vectors from the given multiple
measurement vectors which are different linear combinations of the same known
elementary vectors. This requires careful characterization of robust
complex-valued loss functions as well as Huber's criterion function for the
multivariate sparse regression problem. We devise a greedy algorithm based on
simultaneous normalized iterative hard thresholding (SNIHT) algorithm. Unlike
the conventional SNIHT method, our algorithm, referred to as HUB-SNIHT, is
robust under heavy-tailed non-Gaussian noise conditions, yet has a negligible
performance loss compared to SNIHT under Gaussian noise. Usefulness of the
method is illustrated in source localization application with sensor arrays.Comment: To appear in CoSeRa'15 (Pisa, Italy, June 16-19, 2015). arXiv admin
note: text overlap with arXiv:1502.0244
Sparse EEG Source Localization Using Bernoulli Laplacian Priors
International audienceSource localization in electroencephalography has received an increasing amount of interest in the last decade. Solving the underlying ill-posed inverse problem usually requires choosing an appropriate regularization. The usual l2 norm has been considered and provides solutions with low computational complexity. However, in several situations, realistic brain activity is believed to be focused in a few focal areas. In these cases, the l2 norm is known to overestimate the activated spatial areas. One solution to this problem is to promote sparse solutions for instance based on the l1 norm that are easy to handle with optimization techniques. In this paper, we consider the use of an l0 + l1 norm to enforce sparse source activity (by ensuring the solution has few nonzero elements) while regularizing the nonzero amplitudes of the solution. More precisely, the l0 pseudonorm handles the position of the non zero elements while the l1 norm constrains the values of their amplitudes. We use a BernoulliâLaplace prior to introduce this combined l0 + l1 norm in a Bayesian framework. The proposed Bayesian model is shown to favor sparsity while jointly estimating the model hyperparameters using a Markov chain Monte Carlo sampling technique. We apply the model to both simulated and real EEG data, showing that the proposed method provides better results than the l2 and l1 norms regularizations in the presence of pointwise sources. A comparison with a recent method based on multiple sparse priors is also conducted
Bayesian multi-modal model comparison: a case study on the generators of the spike and the wave in generalized spikeâwave complexes
We present a novel approach to assess the networks involved in the generation of spontaneous pathological brain activity based on multi-modal imaging data. We propose to use probabilistic fMRI-constrained EEG source reconstruction as a complement to EEG-correlated fMRI analysis to disambiguate between networks that co-occur at the fMRI time resolution. The method is based on Bayesian model comparison, where the different models correspond to different combinations of fMRI-activated (or deactivated) cortical clusters. By computing the model evidence (or marginal likelihood) of each and every candidate source space partition, we can infer the most probable set of fMRI regions that has generated a given EEG scalp data window. We illustrate the method using EEG-correlated fMRI data acquired in a patient with ictal generalized spikeâwave (GSW) discharges, to examine whether different networks are involved in the generation of the spike and the wave components, respectively. To this effect, we compared a family of 128 EEG source models, based on the combinations of seven regions haemodynamically involved (deactivated) during a prolonged ictal GSW discharge, namely: bilateral precuneus, bilateral medial frontal gyrus, bilateral middle temporal gyrus, and right cuneus. Bayesian model comparison has revealed the most likely model associated with the spike component to consist of a prefrontal region and bilateral temporalâparietal regions and the most likely model associated with the wave component to comprise the same temporalâparietal regions only. The result supports the hypothesis of different neurophysiological mechanisms underlying the generation of the spike versus wave components of GSW discharges
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