51,860 research outputs found

    Case study of knowledge management implementation in a medium-sized construction sector firm

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    The transient nature of project teams and the competitive environment in which construction organizations operate require an effective mechanism to manage and reuse the knowledge created in the projects without straining its resources. A methodology for “live” capture and reuse of project knowledge was developed for the purpose and encapsulated into a software tool. A study was conducted of a medium-sized UK-based construction sector firm to investigate the use the software tool as the central strand of its knowledge management (KM) framework. The tool was subsequently designed to integrate with a staff profile system and an e-forum. The new system was intended to bridge the communication gap between the company’s geographically dispersed offices by connecting the people together and, hence, facilitating the timely sharing of both tacit and explicit knowledge. Top management’s commitment was found vital in the successful implementation of knowledge management and the nurturing of the desired supportive knowledge-sharing culture. To get the most through the implementation of knowledge management, the various knowledge management practices and relevant information systems of a construction organization need to be strategically integrated to improve the location, capture, and sharing of critical knowledge

    Engineering multiple levels of specificity in an RNA viral vector

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    Synthetic molecular circuits could provide powerful therapeutic capabilities, but delivering them to specific cell types and controlling them remains challenging. An ideal "smart" viral delivery system would enable controlled release of viral vectors from "sender" cells, conditional entry into target cells based on cell-surface proteins, conditional replication specifically in target cells based on their intracellular protein content, and an evolutionarily robust system that allows viral elimination with drugs. Here, combining diverse technologies and components, including pseudotyping, engineered bridge proteins, degrons, and proteases, we demonstrate each of these control modes in a model system based on the rabies virus. This work shows how viral and protein engineering can enable delivery systems with multiple levels of control to maximize therapeutic specificity

    Looking Inwards for Sustainability: Nigerian Cities and Building Demolition-waste or wealth?

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    Cities could generally be described as sustainable before the replacement of manual labour with machines known as the industrial revolution of the 18th century in Europe. Nevertheless, the Industrial Revolution has been associated with environmental degradation and other negative impacts. The trend continued for two centuries until it was realised that there is a limit to the capacity of the earth to withstand such impacts. The damage to the earth needs to be halted by choice or forced by natural consequences. The idea of pursuing economic development with minimum negative socio-economic and environmental impacts comes to be known as Sustainability. The built environment becomes at the centre of the sustainability agenda due to the enormous negative impact to the environment. Moreover, it was reported that 90% of all materials resources ever extracted might be used in the built environment. Unfortunately, many of these materials, including 10% unused are discarded as wastes. In the UK example, 90-120 million tonnes of construction and demolition (C&D) waste is generated annually. This makes C&D wastes even more critical to the sustainability agenda; and in search for solution, in the words of Janine Benyus, it may even involve the urban westerners learning from the wisdom of the preindustrial societies that have been living in harmony with the nature. In the preindustrial community of Kano in Nigeria, there is virtually zero C&D waste; rather it is merchandise. The different categories of the stakeholders were interviewed to establish how the system works, the conditions that led to its emergence, and limitations. It was discovered that the end-of-life management of buildings in Kano is a naturally evolved industrial ecology analogous to the natural ecological system, whereby the bye-product of one process becomes the raw material for another with no waste. Furthermore, a conceptual model of the system was developed using the biomorphic adaptation of the shell of an African snail. It was therefore argued that sustainability practices are inherent within the African traditions rather than to be learnt from outside

    Urban Farming in Inner-City Multi-Storey Car-Parking Structures: Adaptive Reuse Potential

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    The future direction of transport and new global concepts of low-carbon mobility are likely to increase the number of obsolete inner-city multi-storey car-parking structures. The adaptive reuse of these garages is challenged through the continuity of urban change and the need for new mixed-use typologies. The development of technologically advanced farming in these structures could become an innovative strategy that as an interim solution justifies renovation versus demolition and new construction. The paper presents findings from the first stage of the multiple-site case study research on car-parking structures strategically selected in 3 UK cities (Portsmouth, Bristol and Brighton). In order to develop a better understanding of the conditions that enable the implementation of urban hydroponic farming in selected structures planning and technical limitations and opportunities have been identified through the analysis of policies, exploration of layouts using Revit software, field observation and photography. The analysis demonstrated that there is a range of possible uses that may be developed in the process of up-cycling of inner-city car-parking structures, of which one might be hydroponics. Looking at three multi-storey garages has shown that these have similar problems for adaptive reuse, which can be overcome with appropriate architectural strategies. Converting these structures for farming could support addressing social, environmental and economic problems. However, the proposed development requires innovations in planning documents. Further analysis needs to be conducted to assess whether the amount of food that could be produced in such a structure is efficient and comparable with other means of achieving it
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