Exploiting flow dynamics for super-resolution in contrast-enhanced ultrasound

Ultrasound localization microscopy offers new radiation-free diagnostic tools for vascular imaging deep within the tissue. Sequential localization of echoes returned from inert microbubbles with low-concentration within the bloodstream reveal the vasculature with capillary resolution. Despite its high spatial resolution, low microbubble concentrations dictate the acquisition of tens of thousands of images, over the course of several seconds to tens of seconds, to produce a single super-resolved image. %since each echo is required to be well separated from adjacent microbubbles. Such long acquisition times and stringent constraints on microbubble concentration are undesirable in many clinical scenarios. To address these restrictions, sparsity-based approaches have recently been developed. These methods reduce the total acquisition time dramatically, while maintaining good spatial resolution in settings with considerable microbubble overlap. %Yet, non of the reported methods exploit the fact that microbubbles actually flow within the bloodstream. % to improve recovery. Here, we further improve sparsity-based super-resolution ultrasound imaging by exploiting the inherent flow of microbubbles and utilize their motion kinematics. While doing so, we also provide quantitative measurements of microbubble velocities. Our method relies on simultaneous tracking and super-localization of individual microbubbles in a frame-by-frame manner, and as such, may be suitable for real-time implementation. We demonstrate the effectiveness of the proposed approach on both simulations and {\it in-vivo} contrast enhanced human prostate scans, acquired with a clinically approved scanner.Comment: 11 pages, 9 figure

Semantically Guided Depth Upsampling

We present a novel method for accurate and efficient up- sampling of sparse depth data, guided by high-resolution imagery. Our approach goes beyond the use of intensity cues only and additionally exploits object boundary cues through structured edge detection and semantic scene labeling for guidance. Both cues are combined within a geodesic distance measure that allows for boundary-preserving depth in- terpolation while utilizing local context. We model the observed scene structure by locally planar elements and formulate the upsampling task as a global energy minimization problem. Our method determines glob- ally consistent solutions and preserves fine details and sharp depth bound- aries. In our experiments on several public datasets at different levels of application, we demonstrate superior performance of our approach over the state-of-the-art, even for very sparse measurements.Comment: German Conference on Pattern Recognition 2016 (Oral

An Efficient Algorithm for Video Super-Resolution Based On a Sequential Model

In this work, we propose a novel procedure for video super-resolution, that is the recovery of a sequence of high-resolution images from its low-resolution counterpart. Our approach is based on a "sequential" model (i.e., each high-resolution frame is supposed to be a displaced version of the preceding one) and considers the use of sparsity-enforcing priors. Both the recovery of the high-resolution images and the motion fields relating them is tackled. This leads to a large-dimensional, non-convex and non-smooth problem. We propose an algorithmic framework to address the latter. Our approach relies on fast gradient evaluation methods and modern optimization techniques for non-differentiable/non-convex problems. Unlike some other previous works, we show that there exists a provably-convergent method with a complexity linear in the problem dimensions. We assess the proposed optimization method on {several video benchmarks and emphasize its good performance with respect to the state of the art.}Comment: 37 pages, SIAM Journal on Imaging Sciences, 201

Video Frame Interpolation via Adaptive Separable Convolution

Standard video frame interpolation methods first estimate optical flow between input frames and then synthesize an intermediate frame guided by motion. Recent approaches merge these two steps into a single convolution process by convolving input frames with spatially adaptive kernels that account for motion and re-sampling simultaneously. These methods require large kernels to handle large motion, which limits the number of pixels whose kernels can be estimated at once due to the large memory demand. To address this problem, this paper formulates frame interpolation as local separable convolution over input frames using pairs of 1D kernels. Compared to regular 2D kernels, the 1D kernels require significantly fewer parameters to be estimated. Our method develops a deep fully convolutional neural network that takes two input frames and estimates pairs of 1D kernels for all pixels simultaneously. Since our method is able to estimate kernels and synthesizes the whole video frame at once, it allows for the incorporation of perceptual loss to train the neural network to produce visually pleasing frames. This deep neural network is trained end-to-end using widely available video data without any human annotation. Both qualitative and quantitative experiments show that our method provides a practical solution to high-quality video frame interpolation.Comment: ICCV 2017, http://graphics.cs.pdx.edu/project/sepconv