Evaluating the impact of policies recommending PrEP to subpopulations of men and transgender women who have sex with men based on demographic and behavioral risk factors.

IntroductionDeveloping guidelines to inform the use of antiretroviral pre-exposure prophylaxis (PrEP) for HIV prevention in resource-limited settings must necessarily be informed by considering the resources and infrastructure needed for PrEP delivery. We describe an approach that identifies subpopulations of cisgender men who have sex with men (MSM) and transgender women (TGW) to prioritize for the rollout of PrEP in resource-limited settings.MethodsWe use data from the iPrEx study, a multi-national phase III study of PrEP for HIV prevention in MSM/TGW, to build statistical models that identify subpopulations at high risk of HIV acquisition without PrEP, and with high expected PrEP benefit. We then evaluate empirically the population impact of policies recommending PrEP to these subpopulations, and contrast these with existing policies.ResultsA policy recommending PrEP to a high risk subpopulation of MSM/TGW reporting condomless receptive anal intercourse over the last 3 months (estimated 3.3% 1-year HIV incidence) yields an estimated 1.95% absolute reduction in 1-year HIV incidence at the population level, and 3.83% reduction over 2 years. Importantly, such a policy requires rolling PrEP out to just 59.7% of MSM/TGW in the iPrEx population. We find that this policy is identical to that which prioritizes MSM/TGW with high expected PrEP benefit. It is estimated to achieve nearly the same reduction in HIV incidence as the PrEP guideline put forth by the US Centers for Disease Control, which relies on the measurement of more behavioral risk factors and which would recommend PrEP to a larger subset of the MSM/TGW population (86% vs. 60%).ConclusionsThese findings may be used to focus future mathematical modelling studies of PrEP in resource-limited settings on prioritizing PrEP for high-risk subpopulations of MSM/TGW. The statistical approach we took could be employed to develop PrEP policies for other at-risk populations and resource-limited settings

Reciprocal Recommendation System for Online Dating

Online dating sites have become popular platforms for people to look for potential romantic partners. Different from traditional user-item recommendations where the goal is to match items (e.g., books, videos, etc) with a user's interests, a recommendation system for online dating aims to match people who are mutually interested in and likely to communicate with each other. We introduce similarity measures that capture the unique features and characteristics of the online dating network, for example, the interest similarity between two users if they send messages to same users, and attractiveness similarity if they receive messages from same users. A reciprocal score that measures the compatibility between a user and each potential dating candidate is computed and the recommendation list is generated to include users with top scores. The performance of our proposed recommendation system is evaluated on a real-world dataset from a major online dating site in China. The results show that our recommendation algorithms significantly outperform previously proposed approaches, and the collaborative filtering-based algorithms achieve much better performance than content-based algorithms in both precision and recall. Our results also reveal interesting behavioral difference between male and female users when it comes to looking for potential dates. In particular, males tend to be focused on their own interest and oblivious towards their attractiveness to potential dates, while females are more conscientious to their own attractiveness to the other side of the line

Human Papillomavirus (HPV) Vaccine: Attitudes, Behaviors, and Beliefs of At-Risk Women

Cervical cancer is primarily caused by human papillomavirus (HPV) and is the second most common cause of cancer-related mortality among women. Female college students may be at risk for contracting HPV based on their sexual behavior. Following the release of the HPV vaccine, Gardasil®, this cross-sectional study was developed to (1) determine awareness of HPV and Gardasil®, (2) assess attitudes, behaviors, and beliefs about the HPV vaccine, and (3) identify information sources that female college students are accessing. Female college students voluntarily completed a self-administered questionnaire. Statistical analyses included descriptive statistics, Pearson’s correlations and paired sample t-tests. Sexually active respondents would recommend the HPV vaccine to others and disagreed that vaccination would encourage risky sexual behavior. Correlations were identified on how self-reported knowledge influenced attitudes, behaviors, and beliefs regarding the HPV vaccine. These findings should assist in developing integrated public health education efforts for HPV vaccination that are targeted towards this at-risk population

Service-Learning Community Partner Impact Assessment Report

In the summer of 2017, VCU’s Office of Service-Learning conducted an evaluation of the impact of service-learning on community partner organizations. This assessment aimed to collect actionable feedback from partners and to inform improvements to service-learning courses at VCU that successfully address partners’ concerns. An external researcher conducted phone interviews with a representative sample of 22 community partners. Partners were asked how a specific service-learning course impacted their organization in three areas: organizational capacity, economically, and socially. Partners were also asked about faculty interactions and the likelihood of recommending the service-learning course to other organizations like their own. This report presents the findings of this community partner impact assessment, outlines an assessment model for a three-year continuous improvement cycle, and offers key recommendations and next steps that emerged from this assessment

Providing the Missing Link: A Model for a Neighborhood-Focused Employment Program

Outlines a strategy for bridging the gap between low-income neighborhoods and regional workforce development programs. Describes nine implementation steps of a model for increasing career opportunities, and evaluates the feasibility of the program

Planets: Integrated Services for Digital Preservation

The Planets Project is developing services and technology to address core challenges in digital preservation. This article introduces the motivation for this work, describes the extensible technical architecture and places the Planets approach into the context of the Open Archival Information System (OAIS) Reference Model. It also provides a scenario demonstrating Planets’ usefulness in solving real-life digital preservation problems and an overview of the project’s progress to date