A Flexible Approach to Finding Representative Pattern Sets

10.1109/TKDE.2013.27IEEE Transactions on Knowledge and Data Engineerin

Identifying Patient Groups based on Frequent Patterns of Patient Samples

Grouping patients meaningfully can give insights about the different types of patients, their needs, and the priorities. Finding groups that are meaningful is however very challenging as background knowledge is often required to determine what a useful grouping is. In this paper we propose an approach that is able to find groups of patients based on a small sample of positive examples given by a domain expert. Because of that, the approach relies on very limited efforts by the domain experts. The approach groups based on the activities and diagnostic/billing codes within health pathways of patients. To define such a grouping based on the sample of patients efficiently, frequent patterns of activities are discovered and used to measure the similarity between the care pathways of other patients to the patients in the sample group. This approach results in an insightful definition of the group. The proposed approach is evaluated using several datasets obtained from a large university medical center. The evaluation shows F1-scores of around 0.7 for grouping kidney injury and around 0.6 for diabetes

Taming Numbers and Durations in the Model Checking Integrated Planning System

The Model Checking Integrated Planning System (MIPS) is a temporal least commitment heuristic search planner based on a flexible object-oriented workbench architecture. Its design clearly separates explicit and symbolic directed exploration algorithms from the set of on-line and off-line computed estimates and associated data structures. MIPS has shown distinguished performance in the last two international planning competitions. In the last event the description language was extended from pure propositional planning to include numerical state variables, action durations, and plan quality objective functions. Plans were no longer sequences of actions but time-stamped schedules. As a participant of the fully automated track of the competition, MIPS has proven to be a general system; in each track and every benchmark domain it efficiently computed plans of remarkable quality. This article introduces and analyzes the most important algorithmic novelties that were necessary to tackle the new layers of expressiveness in the benchmark problems and to achieve a high level of performance. The extensions include critical path analysis of sequentially generated plans to generate corresponding optimal parallel plans. The linear time algorithm to compute the parallel plan bypasses known NP hardness results for partial ordering by scheduling plans with respect to the set of actions and the imposed precedence relations. The efficiency of this algorithm also allows us to improve the exploration guidance: for each encountered planning state the corresponding approximate sequential plan is scheduled. One major strength of MIPS is its static analysis phase that grounds and simplifies parameterized predicates, functions and operators, that infers knowledge to minimize the state description length, and that detects domain object symmetries. The latter aspect is analyzed in detail. MIPS has been developed to serve as a complete and optimal state space planner, with admissible estimates, exploration engines and branching cuts. In the competition version, however, certain performance compromises had to be made, including floating point arithmetic, weighted heuristic search exploration according to an inadmissible estimate and parameterized optimization

Optical tomography: Image improvement using mixed projection of parallel and fan beam modes

Mixed parallel and fan beam projection is a technique used to increase the quality images. This research focuses on enhancing the image quality in optical tomography. Image quality can be defined by measuring the Peak Signal to Noise Ratio (PSNR) and Normalized Mean Square Error (NMSE) parameters. The findings of this research prove that by combining parallel and fan beam projection, the image quality can be increased by more than 10%in terms of its PSNR value and more than 100% in terms of its NMSE value compared to a single parallel beam

Semiparametric Analysis of the Socio-Demographic and Spatial Determinants of Undernutrition in Two African Countries

We estimate semiparametric regression models of chronic undernutrition (stunting) using the 1992 Demographic and Health Surveys (DHS) from Tanzania and Zambia. We focus particularly on the influence of the child's age, the mother's body mass index, and spatial influences on chronic undernutrition. Conventional parametric regression models are not flexible enough to cope with possibly nonlinear effects of the continuous covariates and cannot flexibly model spatial influences. We present a Bayesian semiparametric analysis of the effects of these two covariates on chronic undernutrition. Moreover, we investigate spatial determinants of undernutrition in these two countries. Compared to previous work with a simple fixed effects approach for the influence of provinces, we model small scale district specific effects using flexible spatial priors. Inference is fully Bayesian and uses recent Markov chain Monte Carlo techniques