A Scalable Automated Diagnostic Feature Extraction System for EEGs

Researchers using Electroencephalograms (“EEGs”) to diagnose clinical outcomes often run into computational complexity problems. In particular, extracting complex, sometimes nonlinear, features from a large number of time-series often require large amounts of processing time. In this paper we describe a distributed system that leverages modern cloud-based technologies and tools and demonstrate that it can effectively, and efficiently, undertake clinical research. Specifically we compare three types of clusters, showing their relative costs (in both time and money) to develop a distributed machine learning pipeline for predicting gestation time based on features extracted from these EEGs

Real-Time Non-Invasive Imaging and Detection of Spreading Depolarizations through EEG: An Ultra-Light Explainable Deep Learning Approach

A core aim of neurocritical care is to prevent secondary brain injury. Spreading depolarizations (SDs) have been identified as an important independent cause of secondary brain injury. SDs are usually detected using invasive electrocorticography recorded at high sampling frequency. Recent pilot studies suggest a possible utility of scalp electrodes generated electroencephalogram (EEG) for non-invasive SD detection. However, noise and attenuation of EEG signals makes this detection task extremely challenging. Previous methods focus on detecting temporal power change of EEG over a fixed high-density map of scalp electrodes, which is not always clinically feasible. Having a specialized spectrogram as an input to the automatic SD detection model, this study is the first to transform SD identification problem from a detection task on a 1-D time-series wave to a task on a sequential 2-D rendered imaging. This study presented a novel ultra-light-weight multi-modal deep-learning network to fuse EEG spectrogram imaging and temporal power vectors to enhance SD identification accuracy over each single electrode, allowing flexible EEG map and paving the way for SD detection on ultra-low-density EEG with variable electrode positioning. Our proposed model has an ultra-fast processing speed (<0.3 sec). Compared to the conventional methods (2 hours), this is a huge advancement towards early SD detection and to facilitate instant brain injury prognosis. Seeing SDs with a new dimension - frequency on spectrograms, we demonstrated that such additional dimension could improve SD detection accuracy, providing preliminary evidence to support the hypothesis that SDs may show implicit features over the frequency profile

Deep learning with convolutional neural networks for decoding and visualization of EEG pathology

We apply convolutional neural networks (ConvNets) to the task of distinguishing pathological from normal EEG recordings in the Temple University Hospital EEG Abnormal Corpus. We use two basic, shallow and deep ConvNet architectures recently shown to decode task-related information from EEG at least as well as established algorithms designed for this purpose. In decoding EEG pathology, both ConvNets reached substantially better accuracies (about 6% better, ~85% vs. ~79%) than the only published result for this dataset, and were still better when using only 1 minute of each recording for training and only six seconds of each recording for testing. We used automated methods to optimize architectural hyperparameters and found intriguingly different ConvNet architectures, e.g., with max pooling as the only nonlinearity. Visualizations of the ConvNet decoding behavior showed that they used spectral power changes in the delta (0-4 Hz) and theta (4-8 Hz) frequency range, possibly alongside other features, consistent with expectations derived from spectral analysis of the EEG data and from the textual medical reports. Analysis of the textual medical reports also highlighted the potential for accuracy increases by integrating contextual information, such as the age of subjects. In summary, the ConvNets and visualization techniques used in this study constitute a next step towards clinically useful automated EEG diagnosis and establish a new baseline for future work on this topic.Comment: Published at IEEE SPMB 2017 https://www.ieeespmb.org/2017

Hardware Implementation of Deep Network Accelerators Towards Healthcare and Biomedical Applications

With the advent of dedicated Deep Learning (DL) accelerators and neuromorphic processors, new opportunities are emerging for applying deep and Spiking Neural Network (SNN) algorithms to healthcare and biomedical applications at the edge. This can facilitate the advancement of the medical Internet of Things (IoT) systems and Point of Care (PoC) devices. In this paper, we provide a tutorial describing how various technologies ranging from emerging memristive devices, to established Field Programmable Gate Arrays (FPGAs), and mature Complementary Metal Oxide Semiconductor (CMOS) technology can be used to develop efficient DL accelerators to solve a wide variety of diagnostic, pattern recognition, and signal processing problems in healthcare. Furthermore, we explore how spiking neuromorphic processors can complement their DL counterparts for processing biomedical signals. After providing the required background, we unify the sparsely distributed research on neural network and neuromorphic hardware implementations as applied to the healthcare domain. In addition, we benchmark various hardware platforms by performing a biomedical electromyography (EMG) signal processing task and drawing comparisons among them in terms of inference delay and energy. Finally, we provide our analysis of the field and share a perspective on the advantages, disadvantages, challenges, and opportunities that different accelerators and neuromorphic processors introduce to healthcare and biomedical domains. This paper can serve a large audience, ranging from nanoelectronics researchers, to biomedical and healthcare practitioners in grasping the fundamental interplay between hardware, algorithms, and clinical adoption of these tools, as we shed light on the future of deep networks and spiking neuromorphic processing systems as proponents for driving biomedical circuits and systems forward.Comment: Submitted to IEEE Transactions on Biomedical Circuits and Systems (21 pages, 10 figures, 5 tables

Classifying sleep-wake stages through recurrent neural networks using pulse oximetry signals

The regulation of the autonomic nervous system changes with the sleep stages causing variations in the physiological variables. We exploit these changes with the aim of classifying the sleep stages in awake or asleep using pulse oximeter signals. We applied a recurrent neural network to heart rate and peripheral oxygen saturation signals to classify the sleep stage every 30 seconds. The network architecture consists of two stacked layers of bidirectional gated recurrent units (GRUs) and a softmax layer to classify the output. In this paper, we used 5000 patients from the Sleep Heart Health Study dataset. 2500 patients were used to train the network, and two subsets of 1250 were used to validate and test the trained models. In the test stage, the best result obtained was 90.13% accuracy, 94.13% sensitivity, 80.26% specificity, 92.05% precision, and 84.68% negative predictive value. Further, the Cohen's Kappa coefficient was 0.74 and the average absolute error percentage to the actual sleep time was 8.9%. The performance of the proposed network is comparable with the state-of-the-art algorithms when they use much more informative signals (except those with EEG).Comment: 12 pages, 4 figures, 2 table