22,006 research outputs found
BioCloud Search EnGene: Surfing Biological Data on the Cloud
The massive production and spread of biomedical data around the web introduces new challenges related to identify computational approaches for providing quality search and browsing of web resources. This papers presents BioCloud Search EnGene (BSE), a cloud application that facilitates searching and integration of the many layers of biological information offered by public large-scale genomic repositories. Grounding on the concept of dataspace, BSE is built on top of a cloud platform that severely curtails issues associated with scalability and performance. Like popular online gene portals, BSE adopts a gene-centric approach: researchers can find their information of interest by means of a simple “Google-like” query interface that accepts standard gene identification as keywords. We present BSE architecture and functionality and discuss how our strategies contribute to successfully tackle big data problems in querying gene-based web resources. BSE is publically available at: http://biocloud-unica.appspot.com/
Two genetic codes: Repetitive syntax for active non-coding RNAs; non-repetitive syntax for the DNA archives
Current knowledge of the RNA world indicates 2 different genetic codes being present throughout the living world. In contrast to non-coding RNAs that are built of repetitive nucleotide syntax, the sequences that serve as templates for proteins share—as main characteristics—a non-repetitive syntax. Whereas non-coding RNAs build groups that serve as regulatory tools in nearly all genetic processes, the coding sections represent the evolutionarily successful function of the genetic information storage medium. This indicates that the differences in their syntax structure are coherent with the differences of the functions they represent. Interestingly, these 2 genetic codes resemble the function of all natural languages, i.e., the repetitive non-coding sequences serve as appropriate tool for organization, coordination and regulation of group behavior, and the nonrepetitive
coding sequences are for conservation of instrumental constructions, plans, blueprints for
complex protein-body architecture. This differentiation may help to better understand RNA group behavioral motifs
Biology of Applied Digital Ecosystems
A primary motivation for our research in Digital Ecosystems is the desire to
exploit the self-organising properties of biological ecosystems. Ecosystems are
thought to be robust, scalable architectures that can automatically solve
complex, dynamic problems. However, the biological processes that contribute to
these properties have not been made explicit in Digital Ecosystems research.
Here, we discuss how biological properties contribute to the self-organising
features of biological ecosystems, including population dynamics, evolution, a
complex dynamic environment, and spatial distributions for generating local
interactions. The potential for exploiting these properties in artificial
systems is then considered. We suggest that several key features of biological
ecosystems have not been fully explored in existing digital ecosystems, and
discuss how mimicking these features may assist in developing robust, scalable
self-organising architectures. An example architecture, the Digital Ecosystem,
is considered in detail. The Digital Ecosystem is then measured experimentally
through simulations, with measures originating from theoretical ecology, to
confirm its likeness to a biological ecosystem. Including the responsiveness to
requests for applications from the user base, as a measure of the 'ecological
succession' (development).Comment: 9 pages, 4 figure, conferenc
The ever-evolving concept of the gene: The use of RNA/Protein experimental techniques to understand genome functions
The completion of the human genome sequence together with advances in sequencing technologies have shifted the paradigm of the genome, as composed of discrete and hereditable coding entities, and have shown the abundance of functional noncoding DNA. This part of the genome, previously dismissed as "junk" DNA, increases proportionally with organismal complexity and contributes to gene regulation beyond the boundaries of known protein-coding genes. Different classes of functionally relevant nonprotein-coding RNAs are transcribed from noncoding DNA sequences. Among them are the long noncoding RNAs (lncRNAs), which are thought to participate in the basal regulation of protein-coding genes at both transcriptional and post-transcriptional levels. Although knowledge of this field is still limited, the ability of lncRNAs to localize in different cellular compartments, to fold into specific secondary structures and to interact with different molecules (RNA or proteins) endows them with multiple regulatory mechanisms. It is becoming evident that lncRNAs may play a crucial role in most biological processes such as the control of development, differentiation and cell growth. This review places the evolution of the concept of the gene in its historical context, from Darwin's hypothetical mechanism of heredity to the post-genomic era. We discuss how the original idea of protein-coding genes as unique determinants of phenotypic traits has been reconsidered in light of the existence of noncoding RNAs. We summarize the technological developments which have been made in the genome-wide identification and study of lncRNAs and emphasize the methodologies that have aided our understanding of the complexity of lncRNA-protein interactions in recent years
Digital Ecosystems: Ecosystem-Oriented Architectures
We view Digital Ecosystems to be the digital counterparts of biological
ecosystems. Here, we are concerned with the creation of these Digital
Ecosystems, exploiting the self-organising properties of biological ecosystems
to evolve high-level software applications. Therefore, we created the Digital
Ecosystem, a novel optimisation technique inspired by biological ecosystems,
where the optimisation works at two levels: a first optimisation, migration of
agents which are distributed in a decentralised peer-to-peer network, operating
continuously in time; this process feeds a second optimisation based on
evolutionary computing that operates locally on single peers and is aimed at
finding solutions to satisfy locally relevant constraints. The Digital
Ecosystem was then measured experimentally through simulations, with measures
originating from theoretical ecology, evaluating its likeness to biological
ecosystems. This included its responsiveness to requests for applications from
the user base, as a measure of the ecological succession (ecosystem maturity).
Overall, we have advanced the understanding of Digital Ecosystems, creating
Ecosystem-Oriented Architectures where the word ecosystem is more than just a
metaphor.Comment: 39 pages, 26 figures, journa
Genetic Programming for Smart Phone Personalisation
Personalisation in smart phones requires adaptability to dynamic context
based on user mobility, application usage and sensor inputs. Current
personalisation approaches, which rely on static logic that is developed a
priori, do not provide sufficient adaptability to dynamic and unexpected
context. This paper proposes genetic programming (GP), which can evolve program
logic in realtime, as an online learning method to deal with the highly dynamic
context in smart phone personalisation. We introduce the concept of
collaborative smart phone personalisation through the GP Island Model, in order
to exploit shared context among co-located phone users and reduce convergence
time. We implement these concepts on real smartphones to demonstrate the
capability of personalisation through GP and to explore the benefits of the
Island Model. Our empirical evaluations on two example applications confirm
that the Island Model can reduce convergence time by up to two-thirds over
standalone GP personalisation.Comment: 43 pages, 11 figure
Infectious Disease Ontology
Technological developments have resulted in tremendous increases in the volume and diversity of the data and information that must be processed in the course of biomedical and clinical research and practice. Researchers are at the same time under ever greater pressure to share data and to take steps to ensure that data resources are interoperable. The use of ontologies to annotate data has proven successful in supporting these goals and in providing new possibilities for the automated processing of data and information. In this chapter, we describe different types of vocabulary resources and emphasize those features of formal ontologies that make them most useful for computational applications. We describe current uses of ontologies and discuss future goals for ontology-based computing, focusing on its use in the field of infectious diseases. We review the largest and most widely used vocabulary resources relevant to the study of infectious diseases and conclude with a description of the Infectious Disease Ontology (IDO) suite of interoperable ontology modules that together cover the entire infectious disease domain
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