Design of a CMOS Analog Front-End for Wearable A-Mode Ultrasound Hand Gesture Recognition

This paper presents a CMOS analog front-end for wearable A-mode ultrasound hand gesture recognition. This analog front-end is part of the research into using ultrasound to record and decode muscle signals with the aim of controlling a prosthetic hand as an alternative to surface electromyography. In this paper, the design of a pulser for driving piezoelectric transducers as well as a low-noise amplifier for the received echoes are presented. Simulation results show that the pulser circuit is capable of driving a 137 pF capacitive load with 30 V pulses at a frequency of 1 MHz and dissipates 142.1 mW power. The low-noise amplifier demonstrates a gain of 34 dB and an input-referred noise of 8.58 nV/√Hz at 1 MHz

Integrated Circuits for Medical Ultrasound Applications: Imaging and Beyond

Medical ultrasound has become a crucial part of modern society and continues to play a vital role in the diagnosis and treatment of illnesses. Over the past decades, the develop- ment of medical ultrasound has seen extraordinary progress as a result of the tremendous research advances in microelectronics, transducer technology and signal processing algorithms. How- ever, medical ultrasound still faces many challenges including power-efficient driving of transducers, low-noise recording of ultrasound echoes, effective beamforming in a non-linear, high- attenuation medium (human tissues) and reduced overall form factor. This paper provides a comprehensive review of the design of integrated circuits for medical ultrasound applications. The most important and ubiquitous modules in a medical ultrasound system are addressed, i) transducer driving circuit, ii) low- noise amplifier, iii) beamforming circuit and iv) analog-digital converter. Within each ultrasound module, some representative research highlights are described followed by a comparison of the state-of-the-art. This paper concludes with a discussion and recommendations for future research directions

Development of electronics for microultrasound capsule endoscopy

Development of intracorporeal devices has surged in the last decade due to advancements in the semiconductor industry, energy storage and low-power sensing systems. This work aims to present a thorough systematic overview and exploration of the microultrasound (µUS) capsule endoscopy (CE) field as the development of electronic components will be key to a successful applicable µUSCE device. The research focused on investigating and designing high-voltage (HV, < 36 V) generating and driving circuits as well as a low-noise amplifier (LNA) for battery-powered and volume-limited systems. In implantable applications, HV generation with maximum efficiency is required to improve the operational lifetime whilst reducing the cost of the device. A fully integrated hybrid (H) charge pump (CP) comprising a serial-parallel (SP) stage was designed and manufactured for > 20 V and 0 - 100 µA output capabilities. The results were compared to a Dickson (DKCP) occupying the same chip area; further improvements in the SPCP topology were explored and a new switching scheme for SPCPs was introduced. A second regulated CP version was excogitated and manufactured to use with an integrated µUS pulse generator. The CP was manufactured and tested at different output currents and capacitive loads; its operation with an US pulser was evaluated and a novel self-oscillating CP mechanism to eliminate the need of an auxiliary clock generator with a minimum area overhead was devised. A single-output universal US pulser was designed, manufactured and tested with 1.5 MHz, 3 MHz, and 28 MHz arrays to achieve a means of fully-integrated, low-power transducer driving. The circuit was evaluated for power consumption and pulse generation capabilities with different loads. Pulse-echo measurements were carried out and compared with those from a commercial US research system to characterise and understand the quality of the generated pulse. A second pulser version for a 28 MHz array was derived to allow control of individual elements. The work involved its optimisation methodology and design of a novel HV feedback-based level-shifter. A low-noise amplifier (LNA) was designed for a wide bandwidth µUS array with a centre frequency of 28 MHz. The LNA was based on an energy-efficient inverter architecture. The circuit encompassed a full power-down functionality and was investigated for a self-biased operation to achieve lower chip area. The explored concepts enable realisation of low power and high performance LNAs for µUS frequencies

MEMS Technology for Biomedical Imaging Applications

Biomedical imaging is the key technique and process to create informative images of the human body or other organic structures for clinical purposes or medical science. Micro-electro-mechanical systems (MEMS) technology has demonstrated enormous potential in biomedical imaging applications due to its outstanding advantages of, for instance, miniaturization, high speed, higher resolution, and convenience of batch fabrication. There are many advancements and breakthroughs developing in the academic community, and there are a few challenges raised accordingly upon the designs, structures, fabrication, integration, and applications of MEMS for all kinds of biomedical imaging. This Special Issue aims to collate and showcase research papers, short commutations, perspectives, and insightful review articles from esteemed colleagues that demonstrate: (1) original works on the topic of MEMS components or devices based on various kinds of mechanisms for biomedical imaging; and (2) new developments and potentials of applying MEMS technology of any kind in biomedical imaging. The objective of this special session is to provide insightful information regarding the technological advancements for the researchers in the community

Beamforming for 3D Transesophageal Echocardiography

In this thesis, we study beamforming techniques that offer opportunities for 3D transesophageal echocardiography imaging, especially to achieve higher frame rates. In 3D TEE with a matrix transducer, two main challenges are to connect a large number of elements to a standard ultrasound system and to achieve a high volume rate (>200 Hz). We develop a prototype miniaturized matrix transducer for pediatric patients with micro-beamforming to reduce the channel count. Initially, we propose two dual stage beamforming techniques for 1D arrays to produce high-quality images with reduced channel count: one using fixed focused receive and another with a simple summation in receive (no delays). Because of their inapplicability to the prototype transducer, we propose multiline 3D ultrasound beamforming schemes that utilize the micro-beamforming capabilities. The proposed beamforming schemes use an angle-weighted combination of the neighboring overlapping sub-volumes to suppress the crossover artifacts that are typical for parallel beamforming and produce high-quality images at a high volume rate (~300 Hz). A similar beamforming scheme adapted for a newly designed prototype matrix adult TEE probe is used for in vivo 3D imaging of the heart of a healthy adult pig to produce good quality 3D images at a high frame rate. The proposed 3D beamforming scheme can easily be adapted for matrix probes with micro-beamforming capabilities to produce good quality volume images at a high volume rate, even for a very different layout of the transmit and receive arrays