Characterization of atorvastatin calcium liquisolid tablets prepared with Neusilin® US2 and Syloid® XDP 3050 as carries

Abstract

Atorvastain calcium (ATC) is a BCS class II drug known for its low absolute bioavailability (12%), which is due to its poor solubility in gastrointestinal fluids [1]. The technology of liquisolid systems (LSS) has been shown to improve the bioavailability of a number of poorly soluble drugs, primarily due to the increased surface area available for dissolution and the presence of the hydrophilic liquid vehicle, resulting in faster drug release [2]. The aim of this study was to investigate the possibility of using the LS technique to improve the dissolution rate of ATC. Two novel porous excipients with high absorption capacity were selected as carriers to formulate LS tablets with high liquid phase content and suitable mechanical properties as well as acceptable disintegration times and improved dissolution rate