Investigating the influence of croscarmellose sodium content on the properties of liquisolid systems prepared with different mesoporous carriers

Abstract

INTRODUCTION The disintegration of tablets in the gastrointestinal fluids is one of the prerequisites for drug absorption and ultimate therapeutic effect (Bhalani, 2022), which is why most tablet formulations require the use of a suitable disintegrant. Liquisolid systems (LSS) are considered a promising technique for improving the oral bioavailability of poorly soluble drugs. The excipients used for their formulation, such as carriers and coating materials, are usually characterised by a large specific surface area required for their intended use. However, they are often hydrophobic, which leads to slow disintegration of the LS tablets. To ensure adequate wetting and disintegration properties, the choice of the appropriate disintegrant and its concentration in these formulations must be carefully considered (Gavali, 2011). The aim of this study was to investigate how different concentrations of croscarmellose sodium (CCS), a widely used superdisintegrant, affect the mechanical properties of LSS prepared with four different mesoporous carriers, their disintegration time and wetting ability